Pulmonary Function in Left Ventricular Failure, Including Cardiac Asthma

Cosby, Richard S.; Stowell, Ellery C.; Hartwig, W; Mayo, Mary

doi:10.1161/01.cir.15.4.492

Cited by 57 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The finding that DL is commonly, although not invariably, reduced in mitral valve disease is well known (9,10,16,17,(36)(37)(38)(39). The significant reduction in mean DL in this group of patients with mitral valve disease is due mainly to a reduction in membrane diffusion; in the majority of patients, Vc was within normal limits, which agrees with the recent findings of Daly, Giamm-nona, Ross, and Feigenbaum (17).…”

Section: Fig 2 Comparison Of Values Found For DL and Dm In Millilisupporting

confidence: 88%

The Diffusing Characteristics and Pressure-Volume Relationships of the Pulmonary Capillary Bed in Mitral Valve Disease*

McCredie¹

1964

J. Clin. Invest.

View full text Add to dashboard Cite

In 1957, Forster, Roughton, and their associates reported a method of estimating pulmonary capillary blood volume (Vc) and diffusing capacity of the alveolar-capillary membrane (DM) by measuring the diffusing capacity of the lung for carbon monoxide (DL) at varying levels of alveolar oxygen tension (1, 2).1 Since then there hlave been a number of reports on the behavior of membrane diffusion and pulmonary capillary blood volume under physiological and pharmacological stresses (3-7) and in certain disease states (8)(9)(10)(11)(12)(13)(14)(15)(16)(17).The purpose of this study was to measure the pulmonary capillary blood volume in normal subjects and in patients with mitral valve disease and to relate the findings to intravascular pressure and flows^data obtained by cardiac catheterization.Most of the studies relating membrane diffusion and pulmonary capillary blood volume to hemodynamic data (5, 10, 11) have used a breath-holding method of estimating diffusing capacity of carbon monoxide (18). The physiological situation within the pulmonary circulation during the breath-holding maneuver differs from that in the resting steady state. For this reason, the steadystate method described in this report was designed to measure Vc so that the volume of blood in the pulmonary capillary bed could be compared with the pressure and flow relationships under the same physiological conditions. * Submitted for publication January 24, 1964; accepted August 7, 1964. t Research fellow, National Heart Foundation of Australia.1 The symbols DL, DM, and Vc, used in the original report (2) and in nearly all subsequent reports on this topic, have been retained here. MethodsTwo groups were studied: 1) The control group consisted of 18 normal subjects, nine of whom were laboratory personnel with no evidence of cardiorespiratory disease; nine were patients with systolic murmurs in whom no other abnormality was detected by physical examination, ECG, and chest X ray, or at cardiac catheterization.2) The abnormal group comprised 18 patients with mitral valve disease, 15 of whom had pure mitral stenosis and three who had dominant mitral incompetence.Cardiac catheterization was performed by standard procedures (19) in the 18 patients with mitral valve disease and in the nine normal subjects who had systolic murmurs. In the normal subjects, catheterization of the right heart only was performed, and pulmonary arterial wedge pressure was obtained as an estimate of left atrial pressure. Left heart catheterization was also performed in all the patients with mitral valve disease, by the transeptal approach (20), and left atrial pressure was recorded directly. Cardiac output was measured by indicator dilution techniques (21); injections of cardiogreen dye were made into the pulmonary artery or left atrium, and dilution curves were recorded from a peripheral artery with a Gilford densitometer. Arterial oxygen saturation was estimated by the spectrophotometric method of Roos and Rich, which is accurate to within 1% in this laboratory (22).2 Before ca...

show abstract

Section: Fig 2 Comparison Of Values Found For DL and Dm In Millilisupporting

confidence: 88%

The Diffusing Characteristics and Pressure-Volume Relationships of the Pulmonary Capillary Bed in Mitral Valve Disease*

McCredie¹

1964

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…Congestive heart failure (CHF) has been reported to produce both restrictive and ob structive defects on pulmonary function test ing [1][2][3][4][5][6][7], Such changes are usually reversible after treatment of cardiac disease. Different mechanisms of improvement of pulmonary function with CHF therapy have been hy pothesized and they are still not completely understood [3,5].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Function Tests in Patients with Congestive Heart Failure: Effects of Medical Therapy

Faggiano¹,

Lombardi

Sorgato³

et al. 1993

Cardiology

View full text Add to dashboard Cite

In a group of 13 patients with severe heart failure, both forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) significantly improved after intensive medical therapy (FVC: from 77 ± 17 to 92 ± 20%, p < 0.001; FEV1: from 65 ± 15 to 81 ± 15%, p < 0.001) in the absence of change in M-mode echo cardiac dimension and left ventricular systolic function; on the other hand, a change of indices of left ventricular filling by Doppler transmitral flow was documented (E/A ratio: from 3.6 ± 1.2 to 1.65 ± 1.5, p < 0.01; early filling deceleration time: from 94 ± 39 to 178 ± 78 ms, p < 0.01), indicating a reduction of pulmonary capillary pressure; this probably positively affected pulmonary interstitial edema and bronchial wall congestion, thus enhancing pulmonary function.

show abstract

“…Severe congestive heart failure (CHF) may reduce both vital capacity and maximal breathing capacity, and cause respiratory insufficiency and occasionally hypercarbia in the adult [2] . But hypercarbia is common in infants with CHF [13,14] .…”

Section: Discussionmentioning

confidence: 99%