Pulmonary Function in Chronic Severe Anaemia

Guleria, J S; Pande, J. N.; Markose, Mathew; Gupta, Ruchika; Jain, Bhavna

doi:10.1042/cs0400317

Cited by 18 publications

(15 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The central or overall respon siveness to increments in C 0 2 is, however, normally preserved. These observations are similar to the findings in permanent high al titude natives [5,7] or patients with cyanot ic congenital heart disease [8], The degree of arterial hypoxia in subjects with anaemia is only minimal [2], although tissue hypoxia may be considerably more pronounced. Moreover, it is not present from birth and acquired for relatively shorter period of time during adult life.…”

Section: Discussionsupporting

confidence: 77%

“…Cerebral hypoxia in itself may have a depressant ef fect on the respiratory centres. Because of these conflicting effects, the resting ventila tion in anaemia has generally been found to be normal [2]. Moreover, the ventilatory re sponse to hypercapnia and hypoxia also has been reported to be normal in chronically anaemic rats [1].…”

Section: Discussionmentioning

confidence: 99%

“…It is well recognized that patients with chronic severe anaemia have significant ar terial hypoxaemia [2]. Hypoxia is a potent stimulant of the peripheral chemoreceptors causing hyperventilation and alkalosis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Peripheral Chemoreceptor Insensitivity in Chronic Severe Anaemia

Vijaylaxmi¹,

Pande²,

Gupta³

et al. 1978

Respiration

View full text Add to dashboard Cite

Ventilatory response to central and peripheral chemoreceptor stimulation by carbon dioxide was assessed in 15 severely and chronically anaemic subjects before and after the correction of anaemia. Whereas the central CO₂ responsiveness was found to be normal in the anaemic state, the peripheral response to CO₂ was remarkably depressed. This blunted peripheral response to CO₂ was restored to normal with the correction of anaemia.

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral Chemoreceptor Insensitivity in Chronic Severe Anaemia

Vijaylaxmi¹,

Pande²,

Gupta³

et al. 1978

Respiration

View full text Add to dashboard Cite

show abstract

“…Thus the explanation for the results before treatment remains unclear. The findings may be contrasted with those for patients with either more-marked irondeficiency anaemia (Rankin et al, 1961 ;Guleria et al, 1971) or sickle-cell anaemia (Miller & Serjeant, 1971 ;Femi-Pearse, Gazioglu & Yu, 1970) in whom the Dm/Vc ratio was decreased on account of low values for Dm which were in some instances compensated for by high values for Vc. This lability of the ratio emphasizes the desirability of making a full allowance for variation in haemoglobin concentration by measurement of Dm and Vc wherever possible.…”

Section: Discussionmentioning

confidence: 72%

Iron-Deficiency Anaemia: Its Effect on Transfer Factor for the Lung (Diffusing Capacity) and Ventilation and Cardiac Frequency during Sub-Maximal Exercise

Cotes¹,

Dabbs²,

Pc³

et al. 1972

Clinical Science

251

117

View full text Add to dashboard Cite

1.Measurements of transfer factor and sub-maximal exercise ventilation and cardiac frequency have been made on twenty women with iron-deficiency anaemia (Hb 8-9 g/100 ml) before and after 'treatment' with iron or placebo tablets and on control subjects.2. The exercise ventilation, cardiac frequency and oxygen uptake were independent of haemoglobin concentration but the transfer factor was lower in the test than in control subjects and was increased by iron but not by placebo treatment. The results support the validity of the reaction-rate data for carbon monoxide with oxyhaemoglobin of Roughton & Forster (1957) despite evidence to the contrary from other studies.3. In interpretation of sub-maximal exercise ventilation and cardiac frequency in iron-deficiency anaemia no allowance need be made for variation in haemoglobin concentration in the range 8-15 g/lW ml. For transfer factor a correction should be made by using a variant of the relationship of Roughton & Forster (1957).Iron-deficiency anaemia is usually evidence for decrease in total body haemoglobin and its subdivisions, including the amount of haemoglobin in pulmonary capillaries. The latter influences directly the overall pulmonary reaction rate for carbon monoxide with oxyhaemoglobin (Roughton & Forster, 1957); thus in anaemia the ability of the lung to absorb carbon monoxide and oxygen from the air and of the circulation to deliver oxygen to the muscles are both decreased.The contribution to gas exchange may be studied by measurement of the transfer factor (diffusing capacity) for carbon monoxide (TI).

show abstract

“…The dependence of this index on haemoglobin concentration has been demonstrated previously in patients with chronic anaemia (Guleria, Pande, Markose, Gupta & Jain, 1971;Oinakara, Blumenthal, Johnston, Kauffman & Solnick, 1970) and polycythaemia (Herbert, Weill, Stuckey, Urner, Gonzales & Ziskand, 1965;Burgess & Bishop, 1963).…”

Section: Introductionmentioning

confidence: 68%

Effect of Blood Transfusion on the Carbon Monoxide Transfer Factor of the Lung in Man

1978

View full text Add to dashboard Cite

1. Ten studies were performed on nine patients with haematological disorders but with normal lungs, who required intermittent blood transfusions. The transfer factor for carbon monoxide and uptake of carbon monoxide per unit lung volume (KCO) were measured with the single breath technique before and at various intervals after transfusion. 2. The mean haemoglobin concentration increased from 7.7 to 11.1 g/dl. 3. The TLCO increased according to a formula based on the Roughton & Forster (1957) diffusion equations. TLCO (standardized) = TLCO (observed). (10.2 + Hb)/1.7 Hb, where haemoglobin (Hb) is expressed as g/dl. 4. The correlation between measured and predicted values was slightly better if changes in alveolar volume were taken into account, by using the KCO value.

show abstract

Pulmonary Function in Chronic Severe Anaemia

Cited by 18 publications

References 10 publications

Peripheral Chemoreceptor Insensitivity in Chronic Severe Anaemia

Peripheral Chemoreceptor Insensitivity in Chronic Severe Anaemia

Iron-Deficiency Anaemia: Its Effect on Transfer Factor for the Lung (Diffusing Capacity) and Ventilation and Cardiac Frequency during Sub-Maximal Exercise

Effect of Blood Transfusion on the Carbon Monoxide Transfer Factor of the Lung in Man

Contact Info

Product

Resources

About