Pulmonary function between 6 and 18 years of age

Abstract

Pulmonary function of children aged 6-18 years is described based on 82,462 annual measurements of forced vital capacity (FVC), forced expired volume in 1 second (FEV1), and forced expiratory flow between 25% and 75% of FVC (FEF25-75%) from 11,630 white children and 989 black children. Median height, FVC, FEV1, FEV1/FVC, and FEF25-75% for each 3 months of age are compared among race and sex subgroups. Race- and sex-specific percentile distributions of FVC, FEV1, FEV1/FVC, and FEF25-75% are presented for each centimeter of height (growth curves). For the same height, boys have greater lung function values than girls, and whites have greater ones than blacks. Lung function increases linearly with age until the adolescent growth spurt at about age 10 years in girls and 12 in boys. The pulmonary function vs. height relationship shifts with age during adolescence. Thus, a single equation or the pulmonary function-height growth chart alone does not completely describe growth during the complex adolescent period. Nevertheless, race- and sex-specific growth curves of pulmonary function vs. height make it easy to display and evaluate repeated measures of pulmonary function for an individual child. Race-, sex-, and age-specific regression equations based on height are provided, which permit the evaluation of growth during adolescence with improved accuracy and, more importantly, in comparison with previous observations for the same child.

IL10 gene polymorphisms are associated with asthma phenotypes in children

“…Pre-and post-bronchodilator measurements were performed and adjusted for age, height, gender, and race [Wang et al, 1993;CAMP Group, 1999]. The bronchodilator albuterol was administered by metered dose inhaler with a spacer and at least 15 min elapsed before post-bronchodilator measurements were obtained.…”

“…The bronchodilator albuterol was administered by metered dose inhaler with a spacer and at least 15 min elapsed before post-bronchodilator measurements were obtained. The FEV 1 measured after bronchodilator administration as a percent of predicted FEV 1 (FEV 1 PP) was the phenotype used to assess lung function [Knudson et al, 1983;Coultas et al, 1988;Wang et al, 1993;Weiss et al, 2000]. The bronchodilator responsiveness phenotypes analyzed were absolute change in FEV 1 before and after bronchodilator in mLs (ABS BD ), the absolute change as a percent of predicted FEV 1 (Pred BD ), and the absolute change as a percent of baseline FEV 1 (FEV BD ).…”

Preferential transmission and association of the −403 G → A promoter RANTES polymorphism with atopic asthma

“…Predicted FEV1 values for adults Z18 years were from Crapo et al 1981 28 and for children o18 yrs from Wang et al 1993. 29 Baseline FEV1 was categorized as above or below the median whole population % predicted value. DNA was isolated from EDTA anticoagulated whole blood using the phenol-chloroform method.…”

Early Childhood Risk Factors for Decreased FEV1at Age 6-7 Years in Young Children with Cystic Fibrosis

“…Potential risk factors reported by parents on the annual family survey included maternal education, household income, immunizations, any exposure to environmental tobacco smoke, breastfeeding, wood-burning stoves, and swimming pools or hot tubs in the previous year. FEV 1 was expressed as a percentage of the predicted value for a healthy reference population based on the equations of Wang and colleagues (14). The data cutoff for the current analysis was December 31, 2013.…”