Pulmonary function and sleep-related breathing disorders in severely obese children

Dubern, B.; Tounian, P.; Medjadhi, N.; Maingot, Lucia; Girardet, Jean-Philippe; Boulé, Michèle

doi:10.1016/j.clnu.2005.12.001

Cited by 41 publications

(29 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, previous studies have shown negative correlation between BMI and spirometric variables, including FEV 1 , FVC, FEF 25-75% and FEV 1 /FVC ratio 1017 , 20 , 29 These findings support the hypothesis that increased body mass cause limitation in diaphragmatic mobility, reduction of costal movement, and impairs pulmonary physiology 710 Griendt et al, 18 demonstrated that body weight reduction is related to significant improvements in FEV 1 , FVC, TLC and ERV, indicating that the BMI reduction contributes to the increase in these outcomes.…”

Section: Discussionmentioning

confidence: 91%

Effects of obesity on lung volume and capacity in children and adolescents: a systematic review

Winck

Heinzmann‐Filho

Soares

et al. 2016

Revista Paulista de Pediatria (English Edition)

View full text Add to dashboard Cite

Objective:To assess the effects of obesity on lung volume and capacity in children and adolescents.Data source:This is a systematic review, carried out in Pubmed, Lilacs, Scielo and PEDro databases, using the following Keywords: Plethysmography; Whole Body OR Lung Volume Measurements OR Total Lung Capacity OR Functional Residual Capacity OR Residual Volume AND Obesity. Observational studies or clinical trials that assessed the effects of obesity on lung volume and capacity in children and adolescents (0-18 years) without any other associated disease; in English; Portuguese and Spanish languages were selected. Methodological quality was assessed by the Agency for Healthcare Research and Quality.Data synthesis:Of the 1,030 articles, only four were included in the review. The studies amounted to 548 participants, predominantly males, with sample size ranging from 45 to 327 individuals. 100% of the studies evaluated nutritional status through BMI (z-score) and 50.0% reported the data on abdominal circumference. All demonstrated that obesity causes negative effects on lung volume and capacity, causing a reduction mainly in functional residual capacity in 75.0% of the studies; in the expiratory reserve volume in 50.0% and in the residual volume in 25.0%. The methodological quality ranged from moderate to high, with 75.0% of the studies classified as having high methodological quality.Conclusions:Obesity causes deleterious effects on lung volume and capacity in children and adolescents, mainly by reducing functional residual capacity, expiratory reserve volume and residual volume.

show abstract

Section: Discussionmentioning

confidence: 91%

Effects of obesity on lung volume and capacity in children and adolescents: a systematic review

Winck

Heinzmann‐Filho

Soares

et al. 2016

Revista Paulista de Pediatria (English Edition)

View full text Add to dashboard Cite

show abstract

“…The structural equation model also indicated that spontaneous arousals and oxygen saturation were weakly although significantly associated with this metabolic variable. Dubern et al 34 found a significant univariate correlation between the arousal index and the HOMA index in 54 severely obese children, although the significance was lost after controlling for age, gender, ethnicity and the Tanner stage. The authors suggested that hormonal influences are more important in the pathogenesis of insulin resistance than sleep-disordered breathing.…”

Section: Sleep Apnea and Metabolic Syndrome Sl Verhulst Et Almentioning

confidence: 98%

Is sleep-disordered breathing an additional risk factor for the metabolic syndrome in obese children and adolescents?

et al. 2008

View full text Add to dashboard Cite

Sleep-disordered breathing is highly prevalent in childhood obesity. Two recent cross-sectional studies have demonstrated an independent association between the severity of sleep-disordered breathing and the metabolic syndrome. A limited number of studies have also addressed the correlation between sleep-disordered breathing and insulin resistance, the core factor of the metabolic syndrome. Cross-sectional reports in modestly obese children are in favor of an association between sleep apnea and insulin resistance. However, these findings were not confirmed in studies of normal-weight children and of morbidly obese children. Only one out of three treatment studies before and after adenotonsillectomy confirmed the association between sleep apnea and insulin resistance, but only in obese children. Although statistical power issues and differences in patient characteristics might partially explain these contradicting results, the evidence to date is far from establishing a causal link between sleep-disordered breathing and insulin resistance. Longitudinal studies and randomized control trials are therefore warranted to investigate a possible causal link between sleep-disordered breathing and insulin resistance.

show abstract

“…52 % des patients avaient un index de désaturation pathologique (plus de 10 évènements par heure de sommeil) et 41 % avaient au moins un des critères considérés comme sévères (index de ronflements > 300, index d'évènements respiratoires > 10 ou index de micro-éveils > 10). L'index de ronflements et l'index d'évènements respiratoires étaient corrélés à l'IMC et au rapport entre tour de cou/taille [3].…”

Section: Données éPidémiologiquesunclassified

Particularités du syndrome d’apnées obstructives du sommeil de l’enfant et de l’adolescent obèses

Aubertin

Dubern

2015

Obes

View full text Add to dashboard Cite

Le syndrome d'apnées obstructives du sommeil (SAOS) touche 1 à 4 % de l'ensemble de la population pédia-trique. L'obésité fait partie des facteurs de risque prédisposants à la survenue de troubles respiratoires du sommeil. La préva-lence des troubles obstructifs du sommeil chez l'enfant obèse est malconnue en France, mais leur fréquence et leur potentielle gravité, en termes de troubles neurocognitifs ou cardiovasculaires notamment, incitent à un dépistage régulier. Dans la première enfance, l'hypertrophie des tissus lymphoïdes demeure la cause principale du SAOS même chez l'enfant obèse. Le diagnostic de certitude repose, comme chez l'adulte, sur la polysomnographie mais les valeurs seuils des index diagnostiques sont nettement plus faibles que chez l'adulte. La prise en charge est globale, multidisciplinaire, pouvant associer avec les mesures diététiques, des interventions chirurgicales, une assistance ventilatoire et un soutien psychologique.Mots clés Troubles respiratoires du sommeil · Apnées · Apnées obstructives du sommeil · SAOS · Polysomnographie · Obésité · Enfant · Adolescent Abstract Obstructive sleep apnea (OSA) is highly prevalent in school-aged children and adolescent. Obesity is major risk factor to the occurrence of sleep-disordered breathing. Prevalence of obstructive sleep disorders in obese children is not well known in France. The screening of these disorders has to be regular, because of their frequency and their potential severity, especially in terms of neurocognitive and cardiovascular disorders. Tonsillar and/or adenoids hypertrophy is the most common etiology of OSA in obsess children. Polysomnography remain the gold standard for the diagnosis of sleep disordered breathing but the diagnostic values are significantly lower than in adults. Treatment of OSA in obese children and adolescent must be based on a multidisciplinary approach with pediatricians, nutritionists, ENT surgeons, psychologists.

show abstract

Pulmonary function and sleep-related breathing disorders in severely obese children

Cited by 41 publications

References 32 publications

Effects of obesity on lung volume and capacity in children and adolescents: a systematic review

Effects of obesity on lung volume and capacity in children and adolescents: a systematic review

Is sleep-disordered breathing an additional risk factor for the metabolic syndrome in obese children and adolescents?

Particularités du syndrome d’apnées obstructives du sommeil de l’enfant et de l’adolescent obèses

Contact Info

Product

Resources

About