Pulmonary Function and Exercise Testing

Chappell, Timothy R.

doi:10.1007/978-1-4613-2847-6_7

Cited by 3 publications

(1 citation statement)

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“…Recently though, Bousfield and colleagues have generated data demonstrating that chromatofocusing does not separate isoforms on the basis of glycan structure suggesting that the isoelectric point is not determined by the glycosylation structure [6]. Nevertheless, the physiological significance of these glycosylated variants is suggested by data demonstrating that the degree of glycosylation that occurs within the anterior pituitary synthetic cells is regulated by exogenous factors including ovarian steroids [7,8]. Tight regulation of this secondary protein processing of glycoprotein hormones suggests an important physiological role for the presence of glycosylated variants of TSH, LH, and FSH.…”

Section: Introductionmentioning

confidence: 91%

Allosteric modulators of glycoprotein hormone receptors: discovery and therapeutic potential

Arey

2008

Endocr

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The glycoprotein hormones, luteinizing hormone, follicle-stimulating hormone and thyroid stimulating hormone, are important regulators of reproductive and metabolic processes. However, because of the nature of their ligand-receptor interactions that contain multiple contact sites, classical small molecule drug discovery strategies have not been successful. However, recent advances in screening and combinatorial chemistry strategies have identified chemical series that act allosterically as positive, negative or mixed modulators of the glycoprotein hormone receptors. This review will discuss the discovery and highlight the currently known series of allosteric modulators to this therapeutically important family of G-protein coupled receptors. Lastly, we will present potential mechanisms whereby the different series could modulate receptor function in the context of currently held theory and known structure of G protein-coupled receptors.

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Section: Introductionmentioning

confidence: 91%

Allosteric modulators of glycoprotein hormone receptors: discovery and therapeutic potential

Arey

2008

Endocr

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Wireless electronic systems for physiological parameters measuring

Štork

Tolar

2014

2014 International Conference on Applied Electronics

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Wireless communication technologies together with physiological signals sensing provide a wide range of capabilities for monitoring, recording and analysis of the physical and health status of individuals. This paper describes two systems using wireless transmission of information designed to measure physiological signals. The first system is system for automatic cardiopulmonary examination measuring and evaluating. The system measures heart rate, pulmonary ventilation, breathing frequency and blood pressure. From these data, many of other standard parameters are calculated. Application of this system is possible in work medicine, sport medicine and rehabilitation. The second system is a system for measuring and wireless transmission of selected physiological signals and variables. The system consists of wireless sensors, data transceivers and information system for the visualization and analysis of measurement data. This paper describes sensor for monitoring of body temperature and RF transceiver, which are being developed as part of the system. Temperature sensor is due to its high demand on low energy consumption not suitable for measuring signals, which will produce large amount of data and therefore consumes more energy on wireless transmission and processing of the data. Due to this reason, this sensor does not measure other signals and measure only temperature so fare. Other sensors, which will measure more physiological signals, like pulse rate, ECG and motion activity of monitored person will be developed in future. Possible use of the sensor or whole system is in a medical environment.

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Assessment of a pharmacist-driven point-of-care spirometry clinic within a primary care physicians office

Cawley

Pacitti

Warning

2011

Pharmacy Practice (Internet)

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ObjectiveTo assess value-added service of a pharmacist-driven point-of-care spirometry clinic to quantify respiratory disease abnormalities within a primary care physicians officeMethodsThis retrospective, cohort study was an analysis of physician referred patients who attended our spirometry clinic during 2008-2010 due to pulmonary symptoms or disease. After spirometry testing, data was collected retrospectively to include patient demographics, spirometry results, and pulmonary pharmaceutical interventions. Abnormal spirometry was identified as an obstructive and/or restrictive defect.ResultsSixty-five patients with a primary diagnosis of cough, shortness of breath, or diagnosis of asthma or chronic obstructive pulmonary disease were referred to the spirometry clinic for evaluation. A total of 51 (32 patients with normal spirometry, 19 abnormal spirometry) completed their scheduled appointment. Calculated lung age was lower in normal spirometry (58.1; SD=20 yrs) than abnormal spirometry (78.2; SD=7.5 yrs, p<0.001). Smoking pack years was also lower in normal spirometry (14.4; SD=10.7 yrs) than abnormal spirometry (32.7; SD=19.5 yrs, p=0.004). Resting oxygen saturation of the arterial blood (SaO2) was higher in normal spirometry than abnormal spirometry (98.1% vs 96.5%, p=0.016). Mean change in the forced expiratory volume in one second (FEV1) after administration of bronchodilator was greater in patients with abnormal spirometry compared with normal spirometry (10.9% vs 4.1%, p<0.001). Spirometry testing assisted in addition, discontinuation or altering pulmonary drug regimens in 41/51 patients (80%) and the need for further diagnostic testing or physician referral in 14/51 patients (27.4%).ConclusionsImplementation of a pharmacist-driven spirometry clinic is a value-added service that can be integrated with other clinical pharmacy services within the ambulatory care setting. Further studies are needed to determine the role of pharmacists in performing spirometry testing and measuring performance outcomes of the pulmonary patient.

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Pulmonary Function and Exercise Testing

Cited by 3 publications

References 144 publications

Allosteric modulators of glycoprotein hormone receptors: discovery and therapeutic potential

Allosteric modulators of glycoprotein hormone receptors: discovery and therapeutic potential

Wireless electronic systems for physiological parameters measuring

Assessment of a pharmacist-driven point-of-care spirometry clinic within a primary care physicians office

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