Pulmonary function abnormalities and airway irritation symptoms of metal fumes exposure on automobile spot welders

Luo, Jiing Chyuan; Hsu, Kuang‐Hung; Shen, Wu-Shiun

doi:10.1002/ajim.20320

Cited by 39 publications

(25 citation statements)

References 31 publications

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“…However, the decreased pulmonary function was only proportional to smoking in Plant 1. The association between welding exposure duration and decreased pulmonary function were in agreement with other investigation [5], [15]. Previous studies on welders also suggest a cumulative relation between the effects of smoking and welding, hence causing increase respiratory symptom and lung disease [8], [9], [11].…”

Section: Methodssupporting

confidence: 91%

Pulmonary Function Status among Welders in Malaysian’s Automotive Industries

Hariri¹,

Paiman²,

Leman³

et al. 2014

JOCET

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Abstract-Welding process has potential physical and chemical health hazards. Welding fumes, toxic gases and metal particles are the chemical hazard that leads to long-term and chronic lung function effects. This study investigates the effects of duration of exposure and smoking status on pulmonary function status among welders of two automotive assembly plants in Malaysia (Plant 1 and Plant 2). This study assesses 61 male welders by pulmonary function test (PFT) using spirometer. These welders worked with spot, metal inert gas (MIG) and robotic welding without the benefit of fume control ventilation or respiratory protective devices. Welding workers in both plants showed significant reduction in lung function parameters relative to controls. The results of the study also showed that in Plant 1, smoking status influence significantly on pulmonary function status. However, in Plant 2, duration of work and smoking status both influence significantly on welders pulmonary function status. This study provides information to welders on chemical hazard effects among Malaysia's automotive industries.

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Section: Methodssupporting

confidence: 91%

Pulmonary Function Status among Welders in Malaysian’s Automotive Industries

Hariri¹,

Paiman²,

Leman³

et al. 2014

JOCET

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“…Reported adverse respiratory outcomes include metal fume fever [2], siderosis [3], lobar pneumonia [4] and less definitively, lung cancer [5,6] and asthma [7][8][9][10][11][12]. Although some studies have shown an increased prevalence of chronic bronchitis in welders [9], this finding is not universal [13].…”

Section: Introductionmentioning

confidence: 73%

Welding, longitudinal lung function decline and chronic respiratory symptoms: a systematic review of cohort studies

et al. 2012

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While the acute respiratory risks of welding are well characterised, more chronic effects, including those on lung function, are less clear. We carried out a systematic review of published longitudinal studies of lung function decline in welders.Original cohort studies documenting two or more sequential measurements of lung function were reviewed. Meta-analysis was carried out on studies with suitable data on forced expiratory volume in 1 s (FEV1).Seven studies were included; their quality (measured on the Newcastle-Ottawa scale) was good, although exposure assessment was limited and the studies showed significant heterogeneity. Five had data suitable for meta-analysis; the pooled estimate of the difference in FEV1 decline between welders and nonwelders was -9.0 mL?year -1 (95% CI -22.5-4.5; p50.193). The pooled estimates of difference in annual FEV1 decline between welders and referents who smoked was -13.7 mL?year -1 (95% CI -33.6-6.3; p50.179). For welders and referents who did not smoke the estimated difference was -3.8 mL?year -1 (95% CI -20.2-12.6; p50.650). Symptom prevalence data were mainly narrative; smoking appeared to have the greatest effect on symptom evolution.Collectively, available longitudinal data on decline of lung function in welders and respiratory symptoms suggest a greater effect in those who smoke, supporting a focus on smoking cessation as well as control of fume exposure in this trade. Further prospective studies are required to confirm these findings. @ERSpublications Welders who smoke suffer greater decline in lung function

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“…Ni is a common component of alloy metals and is used in electroplating, stainless steel, coins, and jewelry (4,6,7). Inhalation of Ni has been associated with lung and nasal cancers (5,(8)(9)(10), fibrosis, and various other cardiopulmonary diseases (1,5), including acute lung injury (4,11).…”

mentioning

confidence: 99%

“…Nickel (Ni) is a well-known environmental and occupational hazard present in air pollution (1), cigarette smoke (2), diesel exhaust (3), and welding fumes (4,5). Ni is a common component of alloy metals and is used in electroplating, stainless steel, coins, and jewelry (4,6,7).…”

mentioning

confidence: 99%

Nickel Mobilizes Intracellular Zinc to Induce Metallothionein in Human Airway Epithelial Cells

Nemec

Leikauf²,

Pitt³

et al. 2009

Am J Respir Cell Mol Biol

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We recently reported that induction of metallothionein (MT) was critical in limiting nickel (Ni)-induced lung injury in intact mice. Nonetheless, the mechanism by which Ni induces MT expression is unclear. We hypothesized that the ability of Ni to mobilize zinc (Zn) may contribute to such regulation and therefore, we examined the mechanism for Ni-induced MT2A expression in human airway epithelial (BEAS-2B) cells. Ni induced MT2A transcript levels and protein expression by 4 hours. Ni also increased the activity of a metal response element (MRE) promoter luciferase reporter construct, suggesting that Ni induces MRE binding of the metal transcription factor (MTF-1). Exposure to Ni resulted in the nuclear translocation of MTF-1, and Ni failed to induce MT in mouse embryonic fibroblasts lacking MTF-1. As Zn is the only metal known to directly bind MTF-1, we then showed that Ni increased a labile pool of intracellular Zn in cells as revealed by fluorescence-activated cell sorter using the Zn-sensitive fluorophore, FluoZin-3. Ni-induced increases in MT2A mRNA and MRE-luciferase activity were sensitive to the Zn chelator, TPEN, supporting an important role for Zn in mediating the effect of Ni. Although neither the source of labile Zn nor the mechanism by which Ni liberates labile Zn was apparent, it was noteworthy that Ni increased intracellular reactive oxygen species (ROS). Although both N-acetyl cysteine (NAC) and ascorbic acid (AA) decreased Ni-induced increases in ROS, only NAC prevented Ni-induced increases in MT2A mRNA, suggesting a special role for interactions of Ni, thiols, and Zn release.

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Pulmonary function abnormalities and airway irritation symptoms of metal fumes exposure on automobile spot welders

Abstract: These findings suggest that restrictive and obstructive lung abnormalities, and airway irritation symptoms are associated with spot and arc welding exposures.

Cited by 39 publications

References 31 publications

Pulmonary Function Status among Welders in Malaysian’s Automotive Industries

Pulmonary Function Status among Welders in Malaysian’s Automotive Industries

Welding, longitudinal lung function decline and chronic respiratory symptoms: a systematic review of cohort studies

Nickel Mobilizes Intracellular Zinc to Induce Metallothionein in Human Airway Epithelial Cells

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