Pulmonary Fibrosis Under Chemotherapy with Oxaliplatin, 5-fluorouracil, and Leucovorin

Jung, Jin Yong; Hur, Gyu Young; Jung, Ki Hwan; Jung, Hae Chul; Lee, Sung Yong; Choi, In Keun; Lee, Sang Yeub; Kim, Je Hyeong; Seo, Jae Hong; Shin, Chol; Shim, Jae Jeong; In, Kwang Ho; Kang, Kyung Ho; Yoo, Se Hwa

doi:10.4046/trd.2005.59.5.536

Cited by 1 publication

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“…[3][4][5][6][7] 항암화학요법은 암세포에 대한 반응 이외에 여러 부작용 이 보고되고 있는데, 5-FU는 점막염, 설사, 수족증후군(handfoot syndrome) 및 골수독성 등 2,8 이, oxaliplatin은 호중구 감소증(neutropenia), 설사 및 감각신경 독성 등이 주된 부작 용으로 보고되고 있다. 9 을 가속화시킬 수 있다. [11][12][13] 신생혈관생성은 전이 발생에 필수 적인데, 누드마우스(nude mice)에서 원발암의 제거가 혈관 생성을 증가시키고, 전이의 성장을 촉진하는 효과는 angiostatin 같은 혈관생성억제제의 감소와 관련 있는 것 같다.…”

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Safety of Early Chemotherapy after a Laparoscopic Colorectal Cancer Resection: A Case-Control Study

Shin

Lee

Choi

et al. 2009

J Korean Soc Coloproctol

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Since micrometastasis is generally inhibited by primary cancer, surgical ablation of the tumor may stimulate the growth of residual cancer cells, if they exist. This supports the importance of early administration of postoperative chemotherapy. Methods: We reviewed the cases of patients who underwent a laparoscopic resection and then received chemotherapy (5 fluorouracil+leucovorin or FOLFOX4) between September 2006 and May 2008. The chemotherapy was scheduled on the 7th or the 8th postoperative day, but was postponed when a final pathologic report was delayed or patients were discharged early. The safety of chemotherapy was evaluated in two ways. Early safety, such as the presence of surgical complications and medical toxicity, was prospectively assessed just before the beginning of the second cycle of chemotherapy. Late safety, such as medical toxicity, was retrospectively estimated from the 2nd to the last cycle. These safeties were compared between the two groups: the early chemotherapy group (n=50) for which chemotherapy started on the 7th or 8th postoperative day as scheduled and the delayed chemotherapy group (n=31) for which chemotherapy started after the 14th postoperative day. Results: Patient demographics were not different between the two groups. With regards to early safety, no differences in surgical complications existed between the two groups. In medical toxicities, there were no differences, except for a higher rate of nausea in the early chemotherapy group (20 percent vs. 10 percent, P=0.01). With regards to late safety, the two groups were not different in the development of medical toxicities. Conclusion: Because nausea is an easily controllable toxicity, we conclude that chemotherapy is safely started on the 7th or the 8th day after a laparoscopic colorectal cancer resection.

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