Pulmonary Fibrosis in Workers Exposed to Finely Powdered Aluminium

Mitchell, John B.; Manning, Georgina; Molyneux, M. K. B.; Lane, Ronald E.

doi:10.1136/oem.18.1.10

Cited by 28 publications

(22 citation statements)

References 1 publication

(1 reference statement)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Stamped aluminum powder is used in the manufacture of pyrotechnics and aluminum dyes. Reports of severe fibrosis of the lungs due to exposure have been primarily from European sources (12)(13)(14)(15), and a dose-response relationship has been suggested. Cases (19).…”

Section: Aluminummentioning

confidence: 99%

“…The prevalence of disease iI workers is not well characterized bt low compared to beryllium c (described in the next section). Th nisms responsible for aluminum parenchymal disease remain poorly d References (7,15,20) Some of the most interesting progress in the (13,18,21) study of metal-induced parenchymal lung disease has occurred regarding beryllium, par- (194,195) ticularly chronic beryllium disease (CBD). The past decade has seen advances in our (812) understanding of the epidemiology of CBD a (82,85) revolution in the methods of disease detection in the workplace and in the use of new diag- (117,118) nostic tools based on immunology, and (196) improvement in our understanding of the immune basis and immunogenetics of this (1,142) disease.…”

Section: Aluminummentioning

confidence: 99%

See 1 more Smart Citation

Inorganic dust pneumonias: the metal-related parenchymal disorders.

Kelleher

Pacheco

Newman

2000

Environ Health Perspect

150

117

View full text Add to dashboard Cite

In recent years the greatest progress in our understanding of pneumoconioses, other than those produced by asbestos, silica, and coal, has been in the arena of metal-induced parenchymal lung disorders. Inhalation of metal dusts and fumes can induce a wide range of lung pathology, including airways disorders, cancer, and parenchymal diseases. The emphasis of this update is on parenchymal diseases caused by metal inhalation, including granulomatous disease, giant cell interstitial pneumonitis, chemical pneumonitis, and interstitial fibrosis, among others. The clinical characteristics, epidemiology, and pathogenesis of disorders arising from exposure to aluminum, beryllium, cadmium, cobalt, copper, iron, mercury, and nickel are presented in detail. Metal fume fever, an inhalation fever syndrome attributed to exposure to a number of metals, is also discussed. Advances in our knowledge of antigen-specific immunologic reactions in the lung are particularly evident in disorders secondary to beryllium and nickel exposure, where immunologic mechanisms have been well characterized. For example, current evidence suggests that beryllium acts as an antigen, or hapten, and is presented by antigen-presenting cells to CD4+ T cells, which possess specific surface antigen receptors. Other metals such as cadmium and mercury induce nonspecific damage, probably by initiating production of reactive oxygen species. Additionally, genetic susceptibility markers associated with increased risk have been identified in some metal-related diseases such as chronic beryllium disease and hard metal disease. Future research needs include development of biologic markers of metal-induced immunologic disease, detailed characterization of human exposure, examination of gene alleles that might confer risk, and association of exposure data with that of genetic susceptibility. Key words: aluminum, beryllium, cadmium, cobalt, copper, hard metal disease, iron, mercury, metal fume fever, nickel, pneumoconiosis. The term pneumoconiosis, first introduced in the 19th century, refers to diseases and pathologic consequences from inhalation of particulate dusts. In recent years the greatest progress in our understanding of pneumoconioses, other than those produced by asbestos, silica, and coal, has been in the arena of metalinduced parenchymal lung disorders. As presented in Table 1 (1). A major theme that emerges in reviewing recent developments in metal-related lung toxicity is the extent to which various metals are capable of inducing both antigen-specific immunologic reactions in the lung and nonspecific "innate" immune system responses characterized by inflammation frequently triggered by oxidant injury. With the recognition of these immune and inflammatory effects comes a growing awareness of the potential hazards to the lung at low levels of exposure. There is also increasing research being conducted on the interaction between metal exposure and the human genome. In the cases of beryllium and cobalt, for example, there is emerging recognition of the spec...

show abstract

Section: Aluminummentioning

confidence: 99%

Section: Aluminummentioning

confidence: 99%

Inorganic dust pneumonias: the metal-related parenchymal disorders.

Kelleher

Pacheco

Newman

2000

Environ Health Perspect

150

117

View full text Add to dashboard Cite

show abstract

“…Pulmonary fibrosis [Goralewslu, 1947;Mitchell et al, 1961;Shaver and Riddell, 1947;Vallyathan et al, 1983;Herbert et al, 1982;Townsend et al, 19881, pulmonary alveolar proteinosis [Miller et al, 19841, chronic pulmonary disease [Discher and Breitenstein, 19761, asthma [Forstad, 1936;Midttun, 1960;Field, 1984;Chan-Yeung et al, 1983;Simonsson et al, 1965;Wergeland et al, 19871, and increased lung cancer mortality [Gibbs and Horowitz, 19791 have been attributed to working with aluminum since 1940. It was estimated by NIOSH that 2 million U.S. workers were exposed to aluminum in 1977.…”

Section: Introductionmentioning

confidence: 99%

Irregular opacities in the lung, occupational asthma, and airways dysfunction in aluminum workers

Kilburn

Warshaw

1992

American J Industrial Med

View full text Add to dashboard Cite

We examined chest X-rays, measured expiratory flows and FVC by spirometry and TLC by projected lung area, ascertained respiratory data by questionnaires, and performed chest examinations in 670 Southeastern aluminum workers and 659 unexposed regional controls. Both groups were asbestos exposed. More aluminum workers had irregular opacities and fewer had pleural abnormalities than did regional pipefitter referents. The pulmonary function tests were expressed as percentage of predicted to adjust for height, age and duration of smoking based on a randomly selected U.S. reference population. Data from aluminum workers were compared to regional controls with students "t" tests run for unequal size groups. Aluminum workers had significant reductions in FEV1 of 3.2% predicted (p less than .003), FEF25-75 of 11.3% predicted (p less than .0001), FEF75-85 of 22.5% predicted (p less than .0001), and an increased TLC of 2.0% predicted (p less than .005). The 145 who had never smoked (NS) were compared with 124 NS controls and showed this same pattern of differences; but in smokers, the differences were significant for mid and terminal flows, but not for FEV1. In aluminum workers who never smoked, asthma prevalence by history was 7.6% vs. 4.0% in controls, and wheezes were heard in 21.4% vs. 2.4% in controls. In aluminum workers who were current smokers, asthma prevalence was 16.4% vs. 9.4% in controls, and wheezes were heard in 43.7% vs. 21.1% in controls. Aluminum workers had significantly more asthma, wheezing, airways obstruction, and pulmonary parenchymal abnormalities similar to asbestosis than did regional blue collar controls not melting and casting aluminum.

show abstract

“…Eventually, it may be represented by focal fibrous areas associated with bronchioles, alveolar ducts, and alveoli (2,3,12,15). Of interest is the relationship between metallic aluminum and the materials t o which it is appended as it enters the respiratory tract.…”

Section: Discussionmentioning

confidence: 99%

The Pulmonary Effects of Pure Aluminum

Greenberg

1977

The Bulletin of the Society of Pharmacological and Environmenta

View full text Add to dashboard Cite

Pulmonary Fibrosis in Workers Exposed to Finely Powdered Aluminium

Cited by 28 publications

References 1 publication

Inorganic dust pneumonias: the metal-related parenchymal disorders.

Inorganic dust pneumonias: the metal-related parenchymal disorders.

Irregular opacities in the lung, occupational asthma, and airways dysfunction in aluminum workers

The Pulmonary Effects of Pure Aluminum

Contact Info

Product

Resources

About