Pulmonary fibrosis in rheumatoid arthritis: A review of clinical features and therapy

Roschmann, R. A.; Rothenberg, Ralph J.

doi:10.1016/0049-0172(87)90020-5

Cited by 91 publications

(57 citation statements)

References 35 publications

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“…Consistent with findings in some prior reports (60), pulmonary function test abnormalities were common in our patient population, with >32% of our patients having at least 1 radiographic or physiologic abnormality suggestive of RA-ILD. Using the ILO scoring system (46), we detected radiographic perfusion abnormalities in 12% of patients, which is slightly higher than has been observed in several other studies (7,18,61).…”

Section: Discussionsupporting

confidence: 79%

Rheumatoid arthritis lung disease. Determinants of radiographic and physiologic abnormalities

Saag

Kolluri

Koehnke

et al. 1996

Arthritis & Rheumatism

219

111

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Objective. To determine the prevalence and important clinical predictors of radiographic and physiologic abnormalities indicative of rheumatoid arthritis interstitial lung disease (RA-ILD).Methods. An unselected cohort of patients with a confirmed diagnosis of RA and known lung disease were identified (n = 336) and evaluated for RA disease activity and seventy. Outcomes included abnormalities determined by the pulmonary function tests of forced vital capacity (FVC) and diffusion capacity for carbon monoxide (DLco), and/or chest radiographic findings of interstitial infiltrates. We used multivariable statistical modeling to determine the independent significance of cigarette smoking and other RA-specific factors on the pulmonary abnormalities of interest.Results. At least 1 of the 3 abnormal findings was identified by pulmonary tests in 32.4% of all patients. These abnormal findings included an FVC <80% of predicted in 42 patients, a DLco <80% of predicted in 64 patients, and evidence of radiographic interstitial infiltrates in 40 patients. After statistical adjustment for confounding factors, pack-years of cigarette smoking remained a significant predictor of low DLco (p = Submitted for publication January 22, 1996; accepted in revised form May 2, 1996. interstitial abnormalities on chest radiograph (odds ratio for 2 2 5 pack-years = 3.76,95% CI 1.59,8.88). The Health Assessment Questionnaire (HAQ) Disability Index (DI) was also an important risk factor for the decline in both the DLco ( p = -1.15, 95% CI -2.00, -0.30) and FVC ( p = -0.23, 95% CI -032, -0.13).-

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Section: Discussionsupporting

confidence: 79%

Rheumatoid arthritis lung disease. Determinants of radiographic and physiologic abnormalities

Saag

Kolluri

Koehnke

et al. 1996

Arthritis & Rheumatism

219

111

View full text Add to dashboard Cite

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“…Corticosteroids are the mainstay of therapy, particularly for cases of NSIP or organising pneumonia where they may lead to regression of consolidation on imaging and potential clinical improvement [28]. Cyclophosphamide and azathioprine have been used with varying success [38,39], and there are a few case reports of ILD regression following cyclosporine treatment [40,41]. More recently, several small studies have demonstrated stabilisation and/ or improvement in symptoms, imaging and PFTs with use of mycophenolate [2,42,43].…”

Section: Managementmentioning

confidence: 99%

Rheumatoid arthritis-associated lung disease

et al. 2015

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“…In ,90% of RA patients, ILD poses no diagnostic difficulties because it follows the onset of joint symptoms by a few years [75,81]; in some cases, joint involvement, albeit present, might be overlooked due to decreased mobility related to pulmonary impairment. However, in ,10% of cases, ILD may be the first manifestation of RA, especially that with the histological pattern of NSIP [10,79,82].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%