Pulmonary fat embolism and related effects during femoral intramedullary surgery: An experimental study in dogs

Zhou, Feihu; Ji, Junfu; Song, Qing; Peng, Zhiyong; Zhang, Guoqiang; Wang, Yan

doi:10.3892/etm.2013.1143

Cited by 7 publications

(6 citation statements)

References 28 publications

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“…These symptoms were all induced in the present CI model, which suggests that a reliable BCIS model was established for the following experiments. Zhou et al established BCIS model with dogs, in a recent study ( 13 ). Blood pressure (BP) and partial pressure of oxygen (PaO 2 ) were both decreased in their models, which were consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

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An Experimental Study to Determine the Role of Inferior Vena Cava Filter in Preventing Bone Cement Implantation Syndrome

Zheng

et al. 2015

Iran J Radiol

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Background:Inferior vena cava filters (IVCF) are frequently used for preventing pulmonary embolism (PE) following deep venous thromboembolism.Objectives:The present study was designed to investigate whether IVCF could prevent or impede the occurrence of bone cement implantation syndrome (BCIS), since PE is considered as the central mechanism of BCIS.Materials and Methods:Fifteen sheep were divided into three groups: bone cement free (BCF) group, cement implantation (CI) group and IVCF group. In all the groups, an osteotomy proximal to the greater trochanter of left femur was carried out. In BCF group, the femoral canal was not reamed out or packed with any bone cement. In CI and IVCF groups, the left femoral canals were packed with bone cement, to simulate the cementing procedures carried out in hip replacement. An OptEase® filter was placed and released in inferior vena cava, prior to packing cement in the femoral canal in IVCF group, while the IVCF was not released in the CI group. The BCF group was considered as control.Results:Systolic blood pressure (SBP), saturation of oxygen (SaO2) and partial pressure of carbon dioxide (PaCO2) declined significantly 10 min after the bone cement packing, in CI group, compared to those in BCF group. This was accompanied by a rise in the arterial pH. However, IVCF prevented those changes in the CI group. On ultrasonography, there were dotted echoes in right atrium in the CI group, after bone cement packing, while such echoes were hardly seen in the IVCF group.Conclusion:This study demonstrates that IVCF could prevent BCIS effectively, and, as a corollary, suggests that PE represents the leading cause of the constellation of BCIS symptoms.

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Section: Discussionmentioning

confidence: 99%

“…However, partial pressure of carbon dioxide went down and arterial pH went up in our models, which were opposite to what was found in Zhou’s models. They used mechanical ventilation during their anesthesia and this might be the reason why their animals did not show respiratory alkalosis ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

An Experimental Study to Determine the Role of Inferior Vena Cava Filter in Preventing Bone Cement Implantation Syndrome

Zheng

et al. 2015

Iran J Radiol

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“…Patients with active pathological changes, including crescents or loop necrosis, should be treated actively. Compared with HD, PD has little influence on the hemodynamics and preserves the RRF well (16,17). PD has been shown to be more conducive to renal function recovery.…”

Section: Discussionmentioning

confidence: 99%

Peritoneal dialysis treatment for severe lupus nephritis patients complicated with essential organ dysfunction

Zhou

Tang

et al. 2015

Experimental and Therapeutic Medicine

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The aim of the present study was to evaluate the clinical efficacy of peritoneal dialysis (PD) in patients with severe lupus nephritis (LN) complicated with organ dysfunction. In total, 13 severe LN patients complicated with multiple-organ dysfunction, who underwent PD treatment between November 2003 and September 2010, were enrolled in the study. Six patients received methylprednisolone pulse therapy due to lupus activity and progressive renal failure. These patients were complicated with severe edema, cardiac insufficiency and severe hypoalbuminemia. PD was applied to the patients, followed by the administration of immunosuppressants. Patients were followed-up to review the parameters of renal function, the immunological indexes and the systemic lupus erythematosus disease activity index. The results indicated that the general state of health was markedly improved following PD treatment, with edema abatement and improvement of heart function and physical strength. Serum creatinine levels significantly decreased from 6.3±1.6 to 2.6±1.0 mg/dl. A total of 10 cases ceased PD treatment during the follow-up, while three cases continued PD to the end of the follow-up period. The levels of albumin and hemoglobin exhibited a marked increase from 29.7±5.7 to 35.2±5.5 g/l and 8.7±1.8 to 9.8±1.8 g/l, respectively. There was one case of peritonitis, one case of peritoneal leakage and two cases of pneumonia. Therefore, PD may be a successful treatment method for severe LN patients complicated with essential organ dysfunction. PD not only improved the symptoms of edema and heart failure, but also played an important role in preserving residual renal function and improving the nutritional state of the patients. Thus, PD can be considered as a treatment option for patients with severe LN associated with acute kidney injury, however, selecting a suitable immunosuppressant during PD treatment is essential.

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“…Currently, more and more different animal models of FES were established with different drugs and methods in various of animals, such as neutral fat in rats, lipopolysaccharide (LPS) in rats, triolein in cats, surgical approach in dogs and rabbit [11][12][13][36][37][38]. In this study, we build the rat models of FES using allograft perirenal fat by tail vein injection.…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, FES can lead to serious pulmonary injury, such as ARDS, pulmonary hypertension, right heart failure, arteriovenous shunt and alveolar hypo-perfusion, interstitial hemorrhage, edema, chemical pneumonia and death [3,6,7] Nowadays, although various methods were employed for treatment of clinical FES, such as early fixation, injury control orthopedics (IVO), extracorporeal membrane lungs and drugs, but the mortality rate still up to 20% [8,9]. Research reported that several animal models for FES were constructed to investigate the mechanism of FES, but the mechanisms of FES remain largely unclear [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Rapamycin Alleviated the Symptoms of Fat Embolism Syndrome by Modulating Autophagy in a Rat Model

Zhang¹,

Zhang²,

Xu³

et al. 2017

Preprint

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As a high fatal disease, fat embolism syndrome is complication, which brought great pain to patient and their family served as a serious social burden. The mechanism of FES remains unclear. Autophagy controls the cell survival and homeostasis by removing the mis-folded proteins and damaged organelles as well as intracellular pathogens through a lysosomal degradation pathway. Increasing research documented that autophagy was wildly involved in variety of human diseases and had huge therapeutic potential. In our study, we first established the rat model of FES with the liquid fat by tail vein injection. We observed the up-regulated MPO expression and activity, increased Wet-to-Dry (W/D) lung weight, promoted quantity of fat granules, and the dominant disorder in the lung rat model of FES, compared to the control group. These observations demonstrated that we successfully build the rat model of FES. Then, we sought to dissect the role of the autophagy in the rat model of FES. The western blots analysis showed that the autophagy was inhibited in the rat model of FES constructed with liquid fat. Furthermore, Rapamycin could restore the repression of autophagy in rat model of FES. These investigations illustrated that autophagy was involved in FES. In addition, our experiments showed that Rapamycin could alleviate the symptoms of FES. Taken together, our study demonstrated the participation of autophagy in FES and further, as a potential therapeutic target, the modulation of autophagy could affect the symptom of rat model of FES.

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Pulmonary fat embolism and related effects during femoral intramedullary surgery: An experimental study in dogs

Cited by 7 publications

References 28 publications

An Experimental Study to Determine the Role of Inferior Vena Cava Filter in Preventing Bone Cement Implantation Syndrome

An Experimental Study to Determine the Role of Inferior Vena Cava Filter in Preventing Bone Cement Implantation Syndrome

Peritoneal dialysis treatment for severe lupus nephritis patients complicated with essential organ dysfunction

Rapamycin Alleviated the Symptoms of Fat Embolism Syndrome by Modulating Autophagy in a Rat Model

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