Pulmonary Eosinophilic Inflammatory Infiltration Post-Intensive Care in a Nearly Drowned Young Man with Papillary Fibroelastoma: A Rare Complication Discovered by Forensic Autopsy

Abstract

Papillary fibroelastoma is a rare benign lesion of heart (1). It is the second most common primary cardiac neoplasm, accounting for 4.4-8% of all tumors of the heart (2). We described a forensic autopsy of a nearly drowned young man with cardiac papillary fibroelastoma who died because of a pulmonary inflammatory infiltration rich in granulocytes after intensive care. This occurrence is rare but possible and should be kept in mind because a lung inflammatory infiltrate rich in eosinophilic granulocytes can be present in different pathological conditions and differential diagnoses are often difficult to do.

The dating of thrombus organization in cases of pulmonary embolism: an autopsy study

“…A recent case report highlighted that although pathology skills are mandatory for an accurate chronological evaluation of fatal PE, histopathology and immunohistochemistry play both a crucial role in the evaluation of PE to the specific case [22]. Therefore, our experience in forensic thanatology [23, 24] reinforces the concept that microscopic observation is at the basis of a correct diagnosis and able to provide informations also for forensic practice and in the specific case in the age-old question of dating [13]. In cases of SUD, the estimate of small time intervals in thrombus formation is difficult but possible.…”

Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective

“…To properly answer these questions, it should be preliminarily stated that, although autopsies are still scarce compared to the entity of the pandemic, the most common pathological lesions in COVID-19 appear to be similar to those seen in the context of other viral and systemic diseases associated with cardiovascular involvement. Based on our autopsy experience [ 54 , 55 , 56 , 57 , 58 ] and current evidence from the literature, it seems that morphological data are still limited to a few cases of meningitis or necrotizing encephalopathy [ 3 , 30 , 58 ]. More recently, it has also been hypothesized that neuropathological changes might be the consequence of direct or immune-mediated damage of the virus, although a secondary lesion from the interaction through the ACE2 receptor or interference with the HEME formation cannot be excluded ( Figure 1 ), as well as an indirect injury from a systemic dysfunction [ 50 , 59 , 60 , 61 , 62 , 63 ].…”

COVID-19: Brief check through the pathologist's eye (autopsy archive)

“…In this brief summary, I would like to induce the reader's reflection to the fact that coronavirus appears already before the pandemic in many texts of medical doctrine and that the pathological findings related to lung and multi-organ damage are described similar to those induced by other viral pathogens both from the same or different family. The autopsy pathologists can confirm that many deaths are due to complications from viral infections especially in subjects with comorbidities and they can also confirm that the aspects often observed are diffuse alveolar damage (DAD), cardiac damage from myocarditis or acute myocardial infarction (AMI), or even disseminated intra-vascular coagulation (DIC); these findings are also present in sepsis associated with various viral infections [ [14] , [15] , [16] , [17] , [18] , [19] , [20] ]. My observation wants to induce the reader to focus on the common histopathological findings that are present in various viral infections, through the clarification of some salient points.…”