Pulmonary Embolism in Patients With COVID-19

Poissy, Julien; Goutay, Julien; Caplan, Morgan; Parmentier, Erika; Duburcq, Thibault; Lassalle, Fanny; Jeanpierre, Emmanuelle; Rauch, Antoine; Labreuche, Julien; Susen, Sophie; Cousin, Nicolas; Durand, Arthur; Kalioubie, Ahmed El; Favory, Raphaël; Girardie, Patrick; Houard, Marion; Jaillette, Emmanuelle; Jourdain, M.; Ledoux, G.; Mathieu, Daniel; Moreau, Anne‐Sophie; Nilès, Christopher; Nseir, Saad; Onimus, Thierry; Preau, Sébastien; Robriquet, Laurent; Rouzé, Anahita; Simonnet, Arthur; Six, Sophie; Toussaint, Aurélia; Dupont, Annabelle; Bauters, Anne; Zawadzki, Christophe; Paris, Camille; Trillot, Nathalie; Wibaut, B.; Hochart, Audrey; Marichez, Catherine; Dalibard, Vincent; Vanderziepe, Sandrine; Bourgeois, Laureline; Gaul, Anaïs; Jospin, Aurélie; Stepina, Nataliia; Pradines, Bénédicte; Tournoys, Antoine; Brousseau, Thierry; Rémy, Martine; Hutt, Antoine

doi:10.1161/circulationaha.120.047430

Cited by 969 publications

(436 citation statements)

References 5 publications

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“…Acute pulmonary embolism, reported in COVID-19 patients [20,[220][221][222], has been shown to be a cause of clinical deterioration in viral pneumonias [205,223]. Endothelial dysfunction is known to be a key determinant in hypertension, thrombosis, and DIC [72,[224][225][226][227].…”

Section: Thromboembolism and Covid-19mentioning

confidence: 99%

Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

Sardu

Gambardella

Morelli

et al. 2020

JCM

445

436

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The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic disorders, and diabetes mellitus) indicate that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations.

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Section: Thromboembolism and Covid-19mentioning

confidence: 99%

Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

Sardu

Gambardella

Morelli

et al. 2020

JCM

445

436

View full text Add to dashboard Cite

show abstract

“…Acute inflammation caused by infection is often followed by a procoagulant state and has been postulated as one of the mechanisms underlying stroke 10 . Studies from the Netherlands and France suggest that blood clots throughout the body appear in 20% to 30% of critically ill COVID-19 patients 11,12 . Coagulation dysfunctions including thrombocytopenia and D-Dimer increase are frequently seen in patients with COVID-19 at the beginning of the so-called hyperinflammatory phase (phase III) of the disease progression and are associated with negative clinical evolution 13 .…”

Section: Cerebrovascular Diseasesmentioning

confidence: 99%

Neurological manifestations and neuro‐invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2

Vonck

Garrez

Herdt

et al. 2020

Euro J of Neurology

101

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Background and purpose Infections with coronaviruses are not always confined to the respiratory tract and various neurological manifestations have been reported. The aim of this study was to perform a review to describe neurological manifestations in patients with COVID‐19 and possible neuro‐invasive mechanisms of Sars‐CoV‐2. Methods PubMed, Web of Science and COVID‐dedicated databases were searched for the combination of COVID‐19 terminology and neurology terminology up to 10 May 2020. Social media channels were followed up between 15 March and 10 May 2020 for postings with the same scope. Neurological manifestations were extracted from the identified papers and combined to provide a useful summary for the neurologist in clinical practice. Results Neurological manifestations potentially related to COVID‐19 have been reported in large studies, case series and case reports and include acute cerebrovascular diseases, impaired consciousness, cranial nerve manifestations and autoimmune disorders such as the Guillain–Barré syndrome often present in patients with more severe COVID‐19. Cranial nerve symptoms such as olfactory and gustatory dysfunctions are highly prevalent in patients with mild to moderate COVID‐19 even without associated nasal symptoms and often present in an early stage of the disease. Conclusion Physicians should be aware of the neurological manifestations in patients with COVID‐19, especially when rapid clinical deterioration occurs. The neurological symptoms in COVID‐19 patients may be due to direct viral neurological injury or indirect neuroinflammatory and autoimmune mechanisms. No antiviral treatments against the virus or vaccines for its prevention are available and the long‐term consequences of the infection on human health remain uncertain especially with regard to the neurological system.

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“…The question of curative anticoagulation is currently an open question that needs to answer in clinical trials. Moreover, in contrast to other respiratory viral pneumonia, an increased pulmonary embolism incidence has been observed in Covid-19 patients [28]. SARS-CoV-2 virus has been shown to infect blood vessels and induce vascular damage in vitro and in vivo [29][30][31].…”

Section: Sars-cov-2 Infection Induces Hematological Disordersmentioning

confidence: 99%

Is COVID-19 a New Hematologic Disease?

Debuc

Smadja

2020

Stem Cell Rev and Rep

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SARS-CoV-2 viruses are positive single-stranded RNA viruses, whose infection can be asymptomatic or lead to the coronavirus disease 2019 . Covid-19 is a respiratory infection with a significant impact on the hematopoietic system and hemostasis leading to several cardiovascular complications. Hematologic consequences of this new infection allowed medical community to start new treatment approaches concerning infection going from targeted anti-inflammatory drugs to anticoagulation or stem cell therapies. A better understanding of Covid-19 pathophysiology, in particular hematological disorders, will help to choose appropriate treatment strategies.

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Pulmonary Embolism in Patients With COVID-19

Cited by 969 publications

References 5 publications

Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

Neurological manifestations and neuro‐invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2

Is COVID-19 a New Hematologic Disease?

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