Pulmonary embolism as the initial clinical presentation of Kimura disease

Xu, Ye; Feng, Ying; Lin, Suxia

doi:10.1097/mbc.0000000000000278

Cited by 10 publications

(9 citation statements)

References 22 publications

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“…Case reports have stated that eosinophilia in patients may be accompanied by thromboembolisms (40)(41)(42). The secretion of ECP (21,43), EDN (43) and MBP (43,44) has been implicated in increasing the probability of thrombosis formation.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic biomarkers for detection of acute exacerbation of chronic obstructive pulmonary disease with or without pulmonary embolism

Yang

Lü

Shu

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Eosinophilia has been implicated in the pathophysiology of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the role of eosinophil activation in the development of AECOPD remains unclear. In the present study, the reliability of plasma levels of eosinophil activation markers, including eosinophil cationic protein (ECP), major basic protein (MBP), eosinophil-derived neurotoxin (EDN) and eosinophil peroxidase (EPX), were measured and used as diagnostic biomarkers of AECOPD with or without pulmonary embolism (PE). A total of 47 patients with AECOPD, 30 patients with AECOPD/PE and 35 healthy adults were enrolled in the present study. Plasma levels of ECP, EDN, EPX and MBP were measured using commercial ELISA kits. The mean concentrations of plasma ECP, EDN, EPX and MBP in the patients with AECOPD was significantly 2.87-, 3.06-, 1.60-and 1.92-fold higher, respectively, compared with the control group (P<0.05). Similar results were obtained in patients with AECOPD/PE, for whom plasma levels of ECP, EDN, EPX and MBP were significantly 2.06-, 2.21-, 1.42-and 2.42-fold higher, respectively, compared with the controls (P<0.05). No significant differences were observed in the levels of these proteins between patients with AECOPD or AECOPD/PE. Among the four potential markers, ECP was determined to be the optimal marker for distinguishing patients with AECOPD or AECOPD/PE from the controls. No significant correlation was observed between marker concentrations and gender, age or disease severity. The results of the present study may have clinical applications in the diagnosis of AECOPD using these novel biomarkers.

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Section: Discussionmentioning

confidence: 99%

Eosinophilic biomarkers for detection of acute exacerbation of chronic obstructive pulmonary disease with or without pulmonary embolism

Yang

Lü

Shu

et al. 2017

Experimental and Therapeutic Medicine

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“…[ 39 ] 1 2014 Chinese Male 53 1.7 × 1.1 × 1.1 neck surgical excision no 1.01 × 10 9 / L 537.2 recurrent / 68 Hsu, S. N. [ 40 ] 1 2015 Chinese Male 33 / head, lower extremity (edema) surgical excision, PTA, Cilostazol 50 mg, Pentoxifylline 400 mg, prednisolone 1 mg/kg/day, Cetirizine 5 mg twice a day no 34 to 51% 12,400-17,200 recurrent / not clear Ye, X. [ 41 ] 1 2015 Chinese Male 47 5 in diameter cervical, subaxillary and inguinal region prednisone 0.5 mg/kg/day, thalidomide 50 mg/day no 26.11% 1081.34 recurrent tapering of prednisolone 36 Wang, H. [ 42 ] 1 2016 Chinese Male 72 / head surgical excision, Chinese herbal remedies, cetirizine hydrochloride and olmesartan 20 mg/day, gamma immunoglobulin 10 g/day for 5 days, intravenous pulse methylprednisolone therapy 500 mg for 3 days, hydroxychloroquine 0.4 g/day, prednisone 50 mg/day, a single dose of intravenous cyclophosphamide 500 mg yes 35% 149,000 recurrent / 43 Matsuo, T. [ 11 ] 1 2017 Japanese Male 42 / head surgical excision, prednisone 40 mg/day, cyclosporine 75 mg/day yes 9.40% 735 recurrent tapering of prednisolone 82 Chakraborti, C. [ ...…”

Section: Discussionmentioning

confidence: 99%

Kimura’s disease mimicking thoracic spine dumbbell neurogenic tumor: a case report and literature review

2020

BMC Surg

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Background Kimura’s disease is a rare, benign chronic inflammatory disease of unknown etiology that mostly affects Asians. The disease typically presents as subcutaneous masses in the head or neck region that are predominantly found in the preauricular and submandibular areas. Case presentation A 7-year-old boy presenting with paralysis of both lower extremities and a thoracic spine dumbbell mass was initially diagnosed with a neurogenic tumor, but the pathological and laboratory examinations confirmed the diagnosis of Kimura’s disease. The paralysis symptom disappeared rapidly, but the patient had developed a recurrent mass in the cervical vertebral canal at the 9-month follow-up. Conclusion To our knowledge, no prior published literature has revealed Kimura’s disease cases that mimic dumbbell neurogenic tumors. Here, we report such a case of Kimura’s disease for the first time and provide a brief review of the literature.

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“…In recent years, severe complications caused by KD, such as cerebral artery embolism, jugular vein embolism, pulmonary embolism, mesenteric embolism, and multiple arterial embolism in extremities have been reported [16]. It is speculated that eosinophilia may play a key role in the occurrence of embolism, but the specific mechanism is unclear [17].…”

Section: Discussionmentioning

confidence: 99%

Kimura’s disease affecting multiple body parts in a 57-year-old female patient: a case report

Liu

Yin

et al. 2019

Allergy Asthma Clin Immunol

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Background: Kimura's disease (KD) is a rare chronic inflammatory disease with unknown etiology. It usually manifests as a painless soft tissue mass or subcutaneous nodule on one side of the patient's head and/or neck and rarely affects multiple parts of the body. The disease is more common among young Asian males. Case presentation: A 57-year-old Chinese woman complained of multiple masses on her body surface. Ultrasonography was used to examine the retroperitoneal, bilateral neck, bilateral supraclavicular, bilateral axillary, and bilateral inguinal superficial lymph nodes. Enlargement of multiple lymph nodes was found in all areas. Many solid nodules were also found in the right parotid gland and right posterior neck area, respectively. Numerous solid nodules were seen on the left chest wall. Laboratory tests showed that the percentage of eosinophils in the whole blood was 39.40%, total immunoglobulin E (IgE) level was > 5000 kU/L, and serum special IgE to Phadiatop (inhaled allergens) and fx5 (food allergens) were 1.01 and 1.04 kUA/L, respectively. After a complete examination, the masses located in the right neck, retroauricular and left axillary regions, and left chest wall were resected directly. Postoperative pathological findings revealed KD. Conclusions: The case discussed in this study is extremely rare and did not meet the common affected areas and age characteristics of KD. This presentation can be used to improve disease awareness among physicians.

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Pulmonary embolism as the initial clinical presentation of Kimura disease

Cited by 10 publications

References 22 publications

Eosinophilic biomarkers for detection of acute exacerbation of chronic obstructive pulmonary disease with or without pulmonary embolism

Eosinophilic biomarkers for detection of acute exacerbation of chronic obstructive pulmonary disease with or without pulmonary embolism

Kimura’s disease mimicking thoracic spine dumbbell neurogenic tumor: a case report and literature review

Kimura’s disease affecting multiple body parts in a 57-year-old female patient: a case report

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