Pulmonary Effects of Inhalation of Aluminum by Rats and Hamsters

Christie, Helen; Mackay, Rosemary J.; Fisher, A. M.

doi:10.1080/00028896309342923

Cited by 13 publications

(6 citation statements)

References 4 publications

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“…Rats and hamsters inhaling aluminum fumes or aluminum powder for up to 13 months initially produced proliferation of macrophages within the alveolar space followed by a PAP (here designated as lipoid pneumonia). In rats, PAP was also diagnosed somewhat earlier than in hamsters (Christie, Mackay, and Fisher 1963). Following inhalation (6 hr/day, 5 days/week, 6 or 12 months) of fine metallic aluminum powders or Al 2 O 3 , PAP occurred in rats, hamsters, and guinea pigs.…”

Section: Experimental Toxicologymentioning

confidence: 94%

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Particle-induced Pulmonary Alveolar Proteinosis and Subsequent Inflammation and Fibrosis: A Toxicologic and Pathologic Review

Bomhard¹

2017

Toxicol Pathol

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This review analyzes the published data on cases of pulmonary alveolar proteinosis (PAP) in workers inhaling crystalline aluminum, indium, silicon, and titanium particles and possible sequelae, that is, inflammation and fibrosis, and compares these findings with those from animal experiments. In inhalation studies in rodents using crystalline indium and gallium compounds, pronounced PAP followed by inflammation and fibrosis down to very low concentration ranges have been reported. Crystalline aluminum, silicon, and titanium compounds also induced comparable pulmonary changes in animals, though at higher exposure levels. Laboratory animal species appear to react to the induction of PAP with varying degrees of sensitivity. The sensitivity of humans to environmental causes of PAP seems to be relatively low. Up to now, no cases of PAP, or other pulmonary diseases in humans, have been described for gallium compounds. However, a hazard potential can be assumed based on the results of animal studies. Specific particle properties, responsible for the induction of PAP and its sequelae, have not been identified. This review provides indications that, both in animal studies and in humans, PAP is not often recognized due to the absence of properly directed investigation or is concealed behind other forms of lung pathology.

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Section: Experimental Toxicologymentioning

confidence: 94%

“…In rats, PAP was also diagnosed somewhat earlier than in hamsters (Christie, Mackay, and Fisher 1963). Following inhalation (6 hr/day, 5 days/week, 6 or 12 months) of fine metallic aluminum powders or Al 2 O 3 , PAP occurred in rats, hamsters, and guinea pigs.…”

Section: Aluminummentioning

confidence: 99%

Particle-induced Pulmonary Alveolar Proteinosis and Subsequent Inflammation and Fibrosis: A Toxicologic and Pathologic Review

Bomhard¹

2017

Toxicol Pathol

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“…Inhalation and ingestion (via food and water) are the two main routes through which Al gets into the body (Alfrey, 1980;Teraoka, 1981;Jouhanneau et al, 1997). Following inhalation, Al compounds are deposited in the lungs (Christie et al, 1963;Stone et al, 1979;Thomson et al, 1986). The lungs continually receive Al mostly as particles of Al silicates and other poorly soluble compounds (Thomson et al, 1986).…”

Section: Absorption Distribution and Elimination Of Aluminiummentioning

confidence: 99%

Aluminium toxicosis: a review of toxic actions and effects

Igbokwe

Igwenagu

Igbokwe

2019

Interdisciplinary Toxicology

259

149

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Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, iron dyshomeostasis, apoptosis, necrosis and dysplasia. The pathological conditions associated with Al toxicosis are desquamative interstitial pneumonia, pulmonary alveolar proteinosis, granulomas, granulomatosis and fibrosis, toxic myocarditis, thrombosis and ischemic stroke, granulomatous enteritis, Crohn’s disease, inflammatory bowel diseases, anemia, Alzheimer’s disease, dementia, sclerosis, autism, macrophagic myofasciitis, osteomalacia, oligospermia and infertility, hepatorenal disease, breast cancer and cyst, pancreatitis, pancreatic necrosis and diabetes mellitus. The review provides a broad overview of Al toxicosis as a background for sustained investigations of the toxicology of Al compounds of public health importance.

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“…Common inorganic compounds of tin include stannous chloride (SnCl 2 ), stannous oxide (SnO), stannous fluoride (SnF 2 ), stannic chloride (SnCl 4 ), and stannic oxide (SnO 2 ). Stannic tin can form a volatile hydride (SnH 4 ) and toxicologically important organometallic compounds (Cima, 2011). (527) Several investigators have reported tin concentrations in tissues collected at autopsy from non-occupationally exposed subjects.…”

Section: Tin (Z = 50)mentioning

confidence: 99%