Pulmonary Effects of Inhalation Of Titanium Dioxide by Rats

Abnormalities of pulmonary function and pleural disease among titanium metal production workers.

“…Similar findings among rats also suggest that pleu ra l changes may occur in response to the inhalation of titanium dioxide (3). Our data are consistent with the hypothesis that titanium dioxide may co ntribute to the de velopment of pleural thickening , but they are not co nclusive because of the limited information available regarding past asbestos exposure in the plant.…”

“…Titanium metal is believed to be biologically inert (2), but there are no reports on the pulmonary response to the inhalation of titanium particulates. Titanium dioxide given to rats by inhalation results in small subpleural deposits of the dust and focal areas of emphysema around the dust aggregates (3). Inhalation studies with rab-bits have demonstrated decreases in pulmonary function accompanied by thickening of the alveolar septae (I).…”

Titandioxid [MAK Value Documentation in German language, 1986]

“…Titandioxid hat sich nach intraperitonealer Applikation bei Ratten als nicht fibrogen erwiesen [14]. Nach inhalativer Aufnahme (Belastungsdauer 13 Monate) wurden bei Ratten keine pathologischen Lungenveränderungen beobachtet [22]. In einer älteren Arbeit von Lenzi [23] wurden obliterierende Bronchiolitiden, Peribronchitiden und peribronchiale Pneumonien an Meerschweinchen nach Titandioxidinhalation beschrieben.…”

Realistic Evaluation of Titanium Dioxide Nanoparticle Exposure in Chewing Gum

“…It has been suggested that nanosized TiO 2 may damage the intestinal epithelium and affect food absorption . In mice, daily oral doses of E171, at levels similar to the estimated human daily intake, resulted in the intestinal accumulation of TiO 2 NPs which promoted mucosal inflammation and facilitated the formation of preneoplastic lesions. , The exposure of rodents to TiO 2 NPs resulted in the induction of oxidative damage, lipid peroxidation, and potential adverse effects on the respiratory, cardiovascular, and nervous systems, also in the absence of detectable titanium in the tissue, suggesting that the effects are mediated by a systemic pathway. , Toxicological studies also found that TiO 2 NPs, inhaled or injected, may predispose one to and/or induce carcinogenicity. , On the basis of the experimental evidence from animal inhalation studies, TiO 2 in nanoparticulate form was classified as a “possible carcinogen to humans” by the International Agency for Research on Cancer and as a “potential occupational carcinogen” by the National Institute for Occupational Safety and Health…”