Pulmonary Effects of Antineoplastic Therapy

Hinkle, Andrea S.; Proukou, Cindy; Chen, Yuhchyau

doi:10.1007/3-540-26498-1_11

Cited by 3 publications

(1 citation statement)

References 123 publications

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“…However, the exact threshold dose for developing pulmonary function impairment after treatment with bleomycin is unclear. Cumulative doses >450 mg/m 2 were reported to be associated with a higher risk of pulmotoxicity, although doses as low as 20 mg/m 2 may also induce pulmonary function impairment 7 24. We observed limited pulmonary function impairment in CCSs treated with bleomycin only.…”

Section: Discussionmentioning

confidence: 53%

Pulmonary function impairment measured by pulmonary function tests in long-term survivors of childhood cancer

Mulder

Thönissen

Pal

et al. 2011

Thorax

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Background Childhood cancer survivors (CCSs) have an increased risk of morbidity and mortality. The prevalence and risk factors of pulmonary function impairment were investigated in a large cohort of CCSs treated with potentially pulmotoxic therapy with a minimal follow-up of 5 years after diagnosis. Methods The study cohort consisted of all adult 5-year CCSs who were treated with bleomycin, pulmonary radiotherapy and/or pulmonary surgery in the Emma Children's Hospital/Academic Medical Center between 1966 and 1996. Pulmonary function tests were performed to diagnose obstructive and restrictive pulmonary function impairment, and diffusion capacity impairment.Results The study population consisted of 220 out of 248 eligible CCSs, of whom 193 (87.7%) had performed a pulmonary function test at a median follow-up of 18 years after diagnosis. 85 (44.0%) out of 193 CCSs developed a pulmonary function impairment. Pulmonary function impairments occurred in all treatment groups. Most prevalent were restrictive pulmonary function impairment (17.6%) and a decreased carbon monoxide diffusion capacity (39.9%). Multivariate logistic regression models showed that, compared with bleomycin treatment only, treatment with radiotherapy, radiotherapy combined with bleomycin and radiotherapy combined with surgery were associated with the highest risk of pulmonary function impairment. Conclusions The prevalence of pulmonary function impairment in long-term adult CCSs who received potentially pulmotoxic therapy is high. Bleomycin, pulmonary radiotherapy and pulmonary surgery are all associated with pulmonary function impairment. Pulmonary radiotherapy, especially in combination with bleomycin or surgery, is the most important risk factor. This emphasises the need for adequate counselling and follow-up for this patient population.

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Section: Discussionmentioning

confidence: 53%

Pulmonary function impairment measured by pulmonary function tests in long-term survivors of childhood cancer

Mulder

Thönissen

Pal

et al. 2011

Thorax

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Aerobic exercise and cardiopulmonary fitness in childhood cancer survivors treated with a cardiotoxic agent: a meta-analysis

Bourdon

Grandy

Keats

2018

Support Care Cancer

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The findings from this review, although not directly demonstrating a cardioprotective effect, are a preliminary step towards establishing the putative cardioprotective effect of aerobic exercise against the direct cardiotoxic impact of cancer treatments. The significant positive effect estimate in favor of aerobic exercise is a small but important advancement towards the standardization of aerobic exercise in childhood cancer survivors. Further studies are necessary.

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Preserved Long-Term Lung Function in Young Adult Survivors of Common Childhood and Adolescence Malignancies

Spicuzza

Cannata

Angileri

et al. 2022

Journal of Adolescent and Young Adult Oncology

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Pulmonary Effects of Antineoplastic Therapy

Cited by 3 publications

References 123 publications

Pulmonary function impairment measured by pulmonary function tests in long-term survivors of childhood cancer

Pulmonary function impairment measured by pulmonary function tests in long-term survivors of childhood cancer

Aerobic exercise and cardiopulmonary fitness in childhood cancer survivors treated with a cardiotoxic agent: a meta-analysis

Preserved Long-Term Lung Function in Young Adult Survivors of Common Childhood and Adolescence Malignancies

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