Pulmonary Edema in Severe Falciparum Malaria

Charoenpan, P; Indraprasit, Suchati; Kiatboonsri, Sumalee; Suvachittanont, O; Tanomsup, Supachai

doi:10.1378/chest.97.5.1190

Cited by 74 publications

(22 citation statements)

References 30 publications

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“…Three cases of ARDS with Plasmodium vivax malaria were also reported in India and one case was demonstrated with bilateral perihilar infiltrates, one case with bilateral diffuse extensive opacities, and another case with bilateral basal ground glass opacities on chest roentgenograms [15]. Pulmonary edema is universal finding at autopsy [16]. The alveoli are filled parasite-red blood cells, nonparasitic red blood cells, neutrophils, and pigment-laden macrophages [16].…”

Section: Pulmonary Malariamentioning

confidence: 99%

“…Pulmonary edema is universal finding at autopsy [16]. The alveoli are filled parasite-red blood cells, nonparasitic red blood cells, neutrophils, and pigment-laden macrophages [16]. In many severe cases, alveoli are lined with a laminated periodic acid-schiff (PAS) positive membrane which finally destroys and incorporated the alveolar wall within it [16].…”

Section: Pulmonary Malariamentioning

confidence: 99%

“…The alveoli are filled parasite-red blood cells, nonparasitic red blood cells, neutrophils, and pigment-laden macrophages [16]. In many severe cases, alveoli are lined with a laminated periodic acid-schiff (PAS) positive membrane which finally destroys and incorporated the alveolar wall within it [16]. This is associated with abundant edematous fluid and pulmonary vasodilatation and may have a marked inflammatory infiltrate [16].…”

Section: Pulmonary Malariamentioning

confidence: 99%

“…In many severe cases, alveoli are lined with a laminated periodic acid-schiff (PAS) positive membrane which finally destroys and incorporated the alveolar wall within it [16]. This is associated with abundant edematous fluid and pulmonary vasodilatation and may have a marked inflammatory infiltrate [16]. There is hyaline membrane formation in the alveoli that indicates leakage of proteinaceous fluid, particularly in falciparum malaria [16].…”

Section: Pulmonary Malariamentioning

confidence: 99%

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Parasitic Pneumonia and Lung Involvement

Cheepsattayakorn

2014

BioMed Research International

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Parasitic infestations demonstrated a decline in the past decade as a result of better hygiene practices and improved socioeconomic conditions. Nevertheless, global immigration, increased numbers of the immunocompromised people, international traveling, global warming, and rapid urbanization of the cities have increased the susceptibility of the world population to parasitic diseases. A number of new human parasites, such as Plasmodium knowlesi, in addition to many potential parasites, have urged the interest of scientific community. A broad spectrum of protozoal parasites frequently affects the respiratory system, particularly the lungs. The diagnosis of parasitic diseases of airway is challenging due to their wide varieties of clinical and roentgenographic presentations. So detailed interrogations of travel history to endemic areas are critical for clinicians or pulmonologists to manage this entity. The migrating adult worms can cause mechanical airway obstruction, while the larvae can cause airway inflammation. This paper provides a comprehensive review of both protozoal and helminthic infestations that affect the airway system, particularly the lungs, including clinical and roentgenographic presentations, diagnostic tests, and therapeutic approaches.

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Section: Pulmonary Malariamentioning

confidence: 99%

Section: Pulmonary Malariamentioning

confidence: 99%

Section: Pulmonary Malariamentioning

confidence: 99%

Section: Pulmonary Malariamentioning

confidence: 99%

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Parasitic Pneumonia and Lung Involvement

Cheepsattayakorn

2014

BioMed Research International

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“…Следует заметить, что при фармакологической оценке обнаруженного нами эффекта артемизинина, обращает на себя внимание тот факт, что в ряде случаев протекание вызванной P. falciparum малярии характеризуется патофизиологическим состоянием, выражающимся в сильной системной вазодилатации, что может приводить к летальным исходам [45,46]. Данное патологическое состояние имеет много общего с септическим шоком, который Пятакова, Северина …”

Section: рисунокunclassified

Soluble guanylate cyclase in the molecular mechanism underlying the therapeutic action of drugs

Pyatakova

Severina

2012

BIOMED KHIM

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The influence of ambroxol - a mucolytic drug - on the activity of human platelet soluble guanylate cyclase and rat lung soluble guanylate cyclase and activation of both enzymes by NO-donors (sodium nitroprusside and Sin-1) were investigated. Ambroxol in the concentration range from 0.1 to 10 μM had no effect on the basal activity of both enzymes. Ambroxol inhibited in a concentration-dependent manner the sodium nitroprusside-induced human platelet soluble guanylate cyclase and rat lung soluble guanylate cyclase with the IC50 values 3.9 and 2.1 μM, respectively. Ambroxol did not influence the stimulation of both enzymes by protoporphyrin IX.The influence of artemisinin - an antimalarial drug - on human platelet soluble guanylate cyclase activity and the enzyme activation by NO-donors were investigated. Artemisinin (0.1-100 μM) had no effect on the basal activity of the enzyme. Artemisinin inhibited in a concentration-dependent manner the sodium nitroprusside-induced activation of human platelet guanylate cyclase with an IC50 value 5.6 μM. Artemisinin (10 μM) also inhibited (by 71±4.0%) the activation of the enzyme by thiol-dependent NO-donor the derivative of furoxan, 3,4-dicyano-1,2,5-oxadiazolo-2-oxide (10 μM), but did not influence the stimulation of soluble guanylate cyclase by protoporphyrin IX. It was concluded that the sygnalling system NO-soluble guanylate cyclase-cGMP is involved in the molecular mechanism of the therapeutic action of ambroxol and artemisinin.

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Malaria

Hommel

Gilles

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Pulmonary Edema in Severe Falciparum Malaria

Cited by 74 publications

References 30 publications

Parasitic Pneumonia and Lung Involvement

Parasitic Pneumonia and Lung Involvement

Soluble guanylate cyclase in the molecular mechanism underlying the therapeutic action of drugs

Malaria

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