Pulmonary Dysfunction in Shock

Js, McLaughlin; LeeLlacer, R; Attar, Safuh; Ra, Chisei

doi:10.1097/00007611-196906000-00009

Southern Medical Journal

1969

DOI: 10.1097/00007611-196906000-00009

|View full text |Cite

Pulmonary Dysfunction in Shock

McLaughlin Js¹,

R LeeLlacer²,

Safuh Attar³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1972

2007

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ARDS was reminiscent of a ''shock lung'' syndrome with pulmonary oedema and hypoxaemia. It was reported following trauma and sepsis, mostly in surgical patients, from both military and civilian hospitals [3][4][5][6][7]. It was later determined that ARDS may afflict individuals of all ages, including infants and newborns, and this eventually led to a name change to acute respiratory distress syndrome.…”

mentioning

confidence: 99%

Ventilator-associated lung injury: a search for better therapeutic targets

Oeckler¹,

Hubmayr²

2007

European Respiratory Journal

View full text Add to dashboard Cite

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) represent a continuum of injury that may arise from a number of primary insults.Localised injury may progress due to trauma from mechanical ventilation, a finding that has led to intense debate in the clinical and experimental literature over optimal ventilator management. The implementation of low tidal volume strategies has led to an improvement in outcomes; however, mortality remains unacceptably high.In the current review, ventilator-associated lung injury is examined, as it relates to the pathophysiological changes beyond direct airway trauma in ALI and ARDS, and an attempt is made to provide a historical perspective to outline potential current and future pitfalls in the use of surrogate end-points and the discovery of potential biomarkers. The systemic responses that lead to multi-organ dysfunction, the leading causes of morbidity and mortality in ALI and ARDS, are caused by pro-inflammatory signalling cascades and the activation of such diverse mediators as reactive oxygen species, immune response elements, apoptotic constituents and coagulation proteins.These areas are examined, including key mediators, and possible future areas of interest are discussed, including the potential of an ''acute lung injury chip'' to integrate measured surrogate biomarkers with real-time clinical information to improve patient outcomes.

show abstract

mentioning

confidence: 99%

Ventilator-associated lung injury: a search for better therapeutic targets

Oeckler¹,

Hubmayr²

2007

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

Acute Respiratory Distress in Adults

Dyck¹,

Zylak²

1973

Radiology

View full text Add to dashboard Cite

The pathophysiology of gram-negative septicaemia*

McGovern

1972

Pathology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Pulmonary Dysfunction in Shock

Cited by 3 publications

References 0 publications

Ventilator-associated lung injury: a search for better therapeutic targets

Ventilator-associated lung injury: a search for better therapeutic targets

Acute Respiratory Distress in Adults

The pathophysiology of gram-negative septicaemia*

Contact Info

Product

Resources

About