Pulmonary Dysfunction in Rheumatoid Arthritis and Systemic Lupus Erythematosus

Newcomer, Albert D.; Miller, R. Drew; Hepper, Norman G.; Carter, Earl T.

doi:10.1378/chest.46.5.562

Cited by 18 publications

(7 citation statements)

References 17 publications

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“…This finding is consistent with an earlier report by Tomasi et al, who documented a positive relationship between rheumatoid factor titers and pulmonary roentgenographic findings (12). Previous series concerning the relationship between RA and diffuse pulmonary fibrosis have for the most part reported findings consistent only with restrictive ventilatory defects (13,14), but such series have usually not included parameters specifically associated with obstruction of the small (I 2 mrn diameter) airways. Those series that have included such measurements either have selected only patients with advanced diffuse interstitial fibrosis (1 5 ) or have attributed the obstructive findings exclusively to tobacco smoking (11 …”

supporting

confidence: 91%

Obstructive pulmonary disease in rheumatoid arthritis

Collins

Turner

Johnson

et al. 1976

Arthritis & Rheumatism

102

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Twenty-six of 43 patients (60.5%) with classic rheumatoid arthritis ( R A ) participating in a controlled, prospective study were found to have maximal midexpiratory flow rates (MMEFs) suggestive of obstructive pulmonary disease. Cigarette smokers with RA had significantly lower MMEFs than either nonsmokers with RA or smokers with degenerative joint disease. There was an increased prevalence of the Pi phenotype M S among the RA patients. Interstitial fibrosis, tobacco smoking, and protease inhibitor deficiencies were all significant factors in producing airway obstruction in patients with RA.A variety of respiratory tract lesions are thought to be associated with rheumatoid arthritis (RA) and are generally called "pleuropulmonary manifestations"

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supporting

confidence: 91%

Obstructive pulmonary disease in rheumatoid arthritis

Collins

Turner

Johnson

et al. 1976

Arthritis & Rheumatism

102

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“…The low transfer factor might be consequent to abnormal alveolar structure, to loss of capillary volume, or to distortion of respiratory bronchioles leading to uneven alveolar ventilation. Newcomer et al (1964) showed that some patients with rheumatoid arthritis had a reduced maximal mid-expiratory flow rate (MMEFR), and this finding was confirmed by Collins et al (1974) who studied 38 patients. The physiological demonstration of possible bronchiolar disease was followed by description of the clinical picture of bronchiolitis by Geddes et al (1977) in six patients.…”

mentioning

confidence: 69%

Frequency dependence of dynamic compliance in patients with rheumatoid arthritis.

Hills¹,

Davies²,

Geary³

1979

Thorax

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“…Surprisingly little attention has been paid to the airways in RA. Reports of lung function tests have been few and have either concentrated on patients with interstitial lung disease (Newcomer et al, 1964;Patterson et al, 1965;Walker and Wright, 1969) or ignored evidence of obstruction, excluding such patients (Worwell et al, 1975) or attributing the abnormalities to smoking. Collins et al (1976) reported airflow obstruction in 26 of 43 patients with RA but 24 of the 26 were smokers.…”

mentioning

confidence: 99%