Pulmonary disease of the newborn

Greenough, Anne; Milner, Anthony; Hannam, Simon; Fox, Grenville; Turowski, Carmen; Davenport, Mark; Morrison, Gavin

doi:10.1016/b978-0-7020-3479-4.00027-1

Cited by 16 publications

(17 citation statements)

References 1,552 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cerebral intraventricular haemorrhage was defined and graded by Papile’s classification (20). Respiratory distress syndrome (RDS) was defined as increasing oxygen needs and reticulogranular chest X‐ray appearance (21). Bronchopulmonary dysplasia (BPD) was defined as need for oxygen supplementation at 36 weeks gestation (22).…”

Section: Methodsmentioning

confidence: 99%

First year growth among very low birth weight infants

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

First year growth among very low birth weight infants

et al. 2010

View full text Add to dashboard Cite

show abstract

“…PPHN was then defined as severe hypoxemia (PaO 2 < 37.5–45 mm Hg in an FiO 2 of 1.0) requiring mechanical ventilation and inhaled nitric oxide treatment (selective pulmonary vasodilator) . Diagnosis of PPHN was only reached if right‐to‐left shunting in the ductus arteriosus was observed by echocardiography, in the absence of a structural heart defect or severe lung hypoplasia . In addition, the following perinatal data were collected: maternal preeclampsia, maternal selective serotonin reuptake inhibitor use during pregnancy, IUTs, ultrasound data prior to IUT, preterm premature rupture of membranes, place of birth, gestational age at birth, birth weight, sex, mode of delivery, Apgar score at 5 minutes, (umbilical cord) blood gas analysis within 1 hour postnatally (pH, base excess, lactate), meconium aspiration syndrome, early‐onset sepsis, perinatal asphyxia, severe brain damage, and mortality within 1 month after birth.…”

Section: Methodsmentioning

confidence: 99%

Persistent pulmonary hypertension of the newborn after fetomaternal hemorrhage

et al. 2018

View full text Add to dashboard Cite

BACKGROUND: Newborns with anemia are at increased risk of persistent pulmonary hypertension of the newborn (PPHN), yet reports on the association between fetomaternal hemorrhage (FMH) and PPHN are rare. To optimize care for pregnancies complicated by FMH, clinicians should be aware of the risks of FMH and the possible diagnostic and therapeutic options. To increase the current knowledge, the incidence of PPHN and short-term neurologic injury in FMH cases were studied. STUDY DESIGN AND METHODS:We included all FMH cases (≥30 mL fetal blood transfused into the maternal circulation) admitted to our neonatal unit between 2006 and 2018. First, we evaluated the incidence of PPHN and short-term neurologic injury. Second, we studied the potential effect of intrauterine transfusion (IUT).RESULTS: PPHN occurred in 37.9% of newborns (11 of 29), respectively, 14.3% (one of seven) and 45.5% (10 of 22) in the IUT group and no-IUT group (p = 0.20). The mortality rate was 13.8% (4 of 29). Severe brain injury occurred in 34.5% (10 of 29), respectively, and 14.3% (one of seven) and 40.9% (nine of 22) in the IUT group and no-IUT group (p = 0.37). ABBREVIATIONS: CTG = cardiotocogram; FMH = fetomaternal hemorrhage; IUT = intrauterine transfusion; LUMC = Leiden University Medical Center; PPHN = persistent pulmonary hypertension of the newborn. From the

show abstract

“…The subsequent increase of lung volume and surface area is due to increase in alveolar size. [1][2][3] Factors which may delay or interfere with alveolarization are mechanical ventilation, antenatal and postnatal glucocorticoids, proinflamatory mediators hyperoxia or hypoxia and poor nutrition. WhereasVitamin A (retinoids) and thyroxine stimulate alveolarization.…”

Section: Discussionmentioning

confidence: 99%