Pulmonary Disease Due to Nontuberculous Mycobacteria

Glassroth, Jeffrey

doi:10.1378/chest.07-0358

Cited by 181 publications

(166 citation statements)

References 66 publications

(74 reference statements)

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“…T he group Actinobacteria contains the large genus Mycobacteria that includes not only the causative agent of tuberculosis, Mycobacterium tuberculosis (MTB), part of the MTB complex, but also Mycobacterium leprae and nontuberculous Mycobacteria (NTMs; also known as "environmental Mycobacteria," "atypical Mycobacteria," and "Mycobacteria other than tuberculosis") (1,2).…”

mentioning

confidence: 99%

Immunological consequences of intragenus conservation ofMycobacterium tuberculosisT-cell epitopes

Arlehamn

Paul

Mele

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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A previous unbiased genome-wide analysis of CD4 Mycobacterium tuberculosis (MTB) recognition using peripheral blood mononuclear cells from individuals with latent MTB infection (LTBI) or nonexposed healthy controls (HCs) revealed that certain MTB sequences were unexpectedly recognized by HCs. In the present study, it was found that, based on their pattern of reactivity, epitopes could be divided into LTBI-specific, mixed reactivity, and HC-specific categories. This pattern corresponded to sequence conservation in nontuberculous mycobacteria (NTMs), suggesting environmental exposure as an underlying cause of differential reactivity. LTBI-specific epitopes were found to be hyperconserved, as previously reported, whereas the opposite was true for NTM conserved epitopes, suggesting that intragenus conservation also influences host pathogen adaptation. The biological relevance of this observation was demonstrated further by several observations. First, the T cells elicited by MTB/NTM cross-reactive epitopes in HCs were found mainly in a CCR6 + CXCR3 + memory subset, similar to findings in LTBI individuals. Thus, both MTB and NTM appear to elicit a phenotypically similar T-cell response. Second, T cells reactive to MTB/NTMconserved epitopes responded to naturally processed epitopes from MTB and NTMs, whereas T cells reactive to MTB-specific epitopes responded only to MTB. Third, cross-reactivity could be translated to antigen recognition. Several MTB candidate vaccine antigens were cross-reactive, but others were MTB-specific. Finally, NTM-specific epitopes that elicit T cells that recognize NTMs but not MTB were identified. These epitopes can be used to characterize T-cell responses to NTMs, eliminating the confounding factor of MTB cross-recognition and providing insights into vaccine design and evaluation.tuberculosis | T-cell epitope | NTM | epitope conservation | T-cell subset

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mentioning

confidence: 99%

Immunological consequences of intragenus conservation ofMycobacterium tuberculosisT-cell epitopes

Arlehamn

Paul

Mele

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…Nevertheless, MAA remains the most prevalent causative agent of avian tuberculosis in domestic hens (Gonzalez et al, 2002, Shitaye et al, 2008a. MAA have also been isolated as non-tuberculous mycobacteria (NTM) species from opportunistic infections in humans (Pavlik et al, 2000;Koh et al, 2002;Glassroth, 2008). In previous studies pulmonary as well as disseminated infections were described (Horsburgh et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Examination of Mycobacterium avium subsp. avium distribution in naturally infected hens by culture and triplex quantitative real time PCR

Kaevska¹,

Slaná²,

Králík³

et al. 2010

Vet. Med. - Czech

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Mycobacterium avium subsp. avium (MAA) is the etiologic agent of avian tuberculosis, a chronic contagious disease described in a wide variety of domestic and wild bird species. The aims of this study were to assess the advantages of triplex quantitative real time PCR (qPCR) in comparison with culture testing for distribution of MAA in the organs of hens displaying varying degrees of clinical symptoms of the disease. From one small flock of ten hens and one cock with a history of weight loss, 98 tissue samples were examined in total. Pathological lesions were observed in six hens from which two were clinically ill. A total of 12 samples were positive by culture and 16 were positive by IS901 and IS1245 qPCR, confirming MAA infection. In conclusion, qPCR was a faster and more reliable alternative method in comparison with conventional culture analysis. Due to the detection of MAA in the muscle tissue of one hen, consumption of under cooked meat originating from infected fowl could pose a threat to immunosuppressed individuals.

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“…In 2014, the World Health Organization (WHO) reported that approximately one-third of the world population was infected with TB, and it was predominantly reported as widespread in countries associated with a high prevalence of human immunodeficiency virus infection (WHO, 2014). M. tuberculosis is found to be the aetiological agent of most TB, but some reports show that the nontuberculous mycobacteria (NTM) could also cause TB-like disease in the immunocompromised host (Koh et al, 2006;Glassroth, 2008;Ryoo et al. 2008;Weiss & Glassroth, 2012).…”

Section: Introductionmentioning

confidence: 99%

Novel targeting of the lepB gene using PCR with confronting two-pair primers for simultaneous detection of Mycobacterium tuberculosis complex and Mycobacterium bovis

Tharinjaroen

Intorasoot

Anukool

et al. 2016

Journal of Medical Microbiology

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Pulmonary Disease Due to Nontuberculous Mycobacteria

Cited by 181 publications

References 66 publications

Immunological consequences of intragenus conservation ofMycobacterium tuberculosisT-cell epitopes

Immunological consequences of intragenus conservation ofMycobacterium tuberculosisT-cell epitopes

Examination of Mycobacterium avium subsp. avium distribution in naturally infected hens by culture and triplex quantitative real time PCR

Novel targeting of the lepB gene using PCR with confronting two-pair primers for simultaneous detection of Mycobacterium tuberculosis complex and Mycobacterium bovis

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