Pulmonary delivery of liposomes co-loaded with SN38 prodrug and curcumin for the treatment of lung cancer

Camptothecin-loaded supramolecular nanodelivery system based on amphiphilic calix[4]arene for targeted tumor therapy

“…The stability of CPT@PDCA in buffers at various pH values was investigated by monitoring the variation in particle size. Briefly, freshly prepared CPT@PDCA was stored at 4 1C, and the particle size of CPT@PDCA was assayed at defined time points (1,2,4,8,12,16,24,32,40,48, 60, and 72 h).…”

“…Advances in recent research have demonstrated that liposomes and cyclodextrins can be used for the delivery of CPT to reduce its toxicity and promote its properties. [15][16][17][18][19][20][21][22][23] However, most of these carriers do not meet the requirements of a high drug-delivery efficiency, ease of dispersion, and controlled particle size, which are key to clinical translation. 24,25 Calixarene (CA), a crucial component of supramolecular families, is a supramolecular macrocyclic compound made of phenol units connected by methylene bridges, with an easy chemical modification of the upper and lower edges of the phenol units, an adjustable size, and conformation of the hydrophobic cavities in the structure.…”

“…Advances in recent research have demonstrated that liposomes and cyclodextrins can be used for the delivery of CPT to reduce its toxicity and promote its properties. 15–23 However, most of these carriers do not meet the requirements of a high drug-delivery efficiency, ease of dispersion, and controlled particle size, which are key to clinical translation. 24,25…”

Nanoparticle drug delivery systems for synergistic delivery of tumor therapy

“…Therefore, F7-Cri-TSL was proposed as a thermosensitive treatment for breast cancer. Gao et al ( Gao et al, 2022 ) used microfluidic technology to design a co-drug delivery system using curcumin (CUR) and prodrug SN38 for treating lung cancer. They linked SN38 to the cell-penetrating peptide TAT through the polyethylene glycol (PEG) linker, which was then co-loaded with liposomes and CUR to form the liposome-TAT-PEG-SN38/CUR complex (size, 171.21 nm).…”

A Guanosine-Derived Antitumor Supramolecular Prodrug

“…Recently, many efforts still focused on various drug delivery strategies to improve the therapeutics index and reduce the serious side effect of CPT-11, including liposomes − and different polymeric materials. − However, the prodrug molecules in almost all designs were based on the covalent linkage with 10-OH (or 20-OH) of SN38 via a carboxylate bond; thus, the release of drug in vivo will still partly depend on carboxylesterase. The esterase in plasma can also accelerate the metabolic clearance rate of drugs and reduce the drug concentration in focal tissues.…”