Pulmonary delivery of curcumin-loaded glycyrrhizic acid nanoparticles for anti-inflammatory therapy

Piao, Chunxian; Zhuang, Chuanyu; Kang, Minji; Oh, Jihun; Lee, Minhyung

doi:10.1039/d2bm00756h

Cited by 13 publications

(5 citation statements)

References 23 publications

(30 reference statements)

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“…GA can also be used as a multi-functional drug carrier to enhance the activity of other drugs ( Selyutina and Polyakov, 2019 ). Chunxian Piao ( Piao et al, 2022 ) prepared curcumin-loaded acidic nanoparticles by self-assembly method. The results showed that compared with glycyrrhizic acid + curcumin, curcumin-loaded glycyrrhizic acid nanoparticles had higher anti-inflammatory effects in vitro-in vivo by reducing pro-inflammatory cytokines.…”

Section: Introductionmentioning

confidence: 99%

Glycyrrhizic acid modified Poria cocos polyscaccharide carbon dots dissolving microneedles for methotrexate delivery to treat rheumatoid arthritis

Chang

Wang

et al. 2023

Front. Chem.

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Introduction: Rheumatoid arthritis is an autoimmune disease characterized by chronic joint inflammation. Methotrexate is one of the most effective drugs for rheumatoid arthritis, but the adverse reactions caused by oral methotrexate greatly limit its clinical application. Transdermal drug delivery system is an ideal alternative to oral methotrexate by absorbing drugs into the human body through the skin. However, methotrexate in the existing methotrexate microneedles is mostly used alone, and there are few reports of combined use with other anti-inflammatory drugs.Methods: In this study, glycyrrhizic acid was first modified onto carbon dots, and then methotrexate was loaded to construct a nano-drug delivery system with fluorescence and dual anti-inflammatory effects. Then hyaluronic acid was combined with nano-drug delivery system to prepare biodegradable soluble microneedles for transdermal drug delivery of rheumatoid arthritis. The prepared nano-drug delivery system was characterized by transmission electron microscopy, fluorescence spectroscopy, laser nanoparticle size analyzer, ultraviolet-visible absorption spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimeter and nuclear magnetic resonance spectrometer. The results showed that glycyrrhizic acid and methotrexate were successfully loaded on carbon dots, and the drug loading of methotrexate was 49.09%. The inflammatory cell model was constructed by lipopolysaccharide-induced RAW264.7 cells. In vitro cell experiments were used to explore the inhibitory effect of the constructed nano-drug delivery system on the secretion of inflammatory factors by macrophages and the cell imaging ability. The drug loading, skin penetration ability, in vitro transdermal delivery and in vivo dissolution characteristics of the prepared microneedles were investigated. The rat model of rheumatoid arthritis was induced by Freund's complete adjuvant.Results: The results of in vivo animal experiments showed that the soluble microneedles of the nano drug delivery system designed and prepared in this study could significantly inhibit the secretion of pro-inflammatory cytokines and had a significant therapeutic effect on arthritis.Discussion: The prepared glycyrrhizic acid-carbon dots-methotrexate soluble microneedle provides a feasible solution for the treatment of Rheumatoid arthritis.

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Section: Introductionmentioning

confidence: 99%

Glycyrrhizic acid modified Poria cocos polyscaccharide carbon dots dissolving microneedles for methotrexate delivery to treat rheumatoid arthritis

Chang

Wang

et al. 2023

Front. Chem.

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“…Glycyrrhizin can be effective in drug delivery applications by enhancing the therapeutic activity of other drugs ( Piao et al, 2022 ). Its amphiphilic properties enable it to form self-associates like dimers and micelles and bind to hydrophobic drugs by supramolecular complexes ( Sun et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of sildenafil/glycyrrhizin-loaded nanofibers as a potential novel buccal delivery system for erectile dysfunction

Alamer,

Alshehri,

Aodah

et al. 2024

Saudi Pharmaceutical Journal

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“…Micelles are spherical structures with hydrophobic cores and hydrophilic shell . The shell makes them soluble in water, enabling intravenous delivery, while the core is loaded with hydrophobic therapeutic agents such as curcumin, doxorubicin, and others. − In this study, the anticancer therapeutic drug Temozolomide (TMZ) for GBM was loaded into T7-chol. TMZ serves as a chemotherapeutic agent for treating GBM, but has limitations including a short half-life of 1.8 h, susceptibility to degradation under physiological conditions, and rapid metabolism at pH (>7.0). − This suggests that TMZ-loaded T7-chol micelles may mitigate degradation under physiological conditions, thereby potentially enhancing drug delivery efficiency.…”

Section: Introductionmentioning

confidence: 99%

Targeted Delivery of Nanoparticle-Conveyed Neutrophils to the Glioblastoma Site for Efficient Therapy

Piao,

Lee,

Kim

et al. 2024

ACS Appl. Mater. Interfaces

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Glioblastoma is a common brain tumor that poses considerable challenges in drug delivery. In this study, we investigated the potential of cell-based nanoparticles for targeted drug delivery to the glioblastoma sites. The anticancer drug of temozolomide (TMZ)-loaded T7-cholesterol nanoparticle micelles efficiently delivered nanoparticles to neutrophils and, subsequently, to the tumors. T7 is a cell-penetrating peptide that enhances the delivery of T7/TMZ to the target cells. T7 also serves as a transferrin target peptide, enabling targeted delivery to tumors. T7conjugated cholesterol can self-assemble into micelles in aqueous solution and attach to the membrane of neutrophils. We confirmed that T7/TMZ nanoparticle micelles were efficiently located inside the neutrophils. Thereafter, T7/TMZ-conveyed neutrophils were administered to a glioblastoma mouse model, enabling neutrophils to penetrate the blood-brain barrier and deliver drugs directly to the tumor site. We evaluated the drug delivery efficiency and therapeutic effects of intravenous injection of T7/TMZ-conveyed neutrophils to a glioblastoma mouse model. These results demonstrate the promising role of neutrophil-based nanoparticle delivery systems in the targeted therapy of glioblastoma.

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Pulmonary delivery of curcumin-loaded glycyrrhizic acid nanoparticles for anti-inflammatory therapy

Abstract: Acute lung injury (ALI) is an inflammatory disease in the lungs. Curcumin (Cur) has protective effects in ALI animal models. However, Cur is a hydrophobic drug and administration into the...

Cited by 13 publications

References 23 publications

Glycyrrhizic acid modified Poria cocos polyscaccharide carbon dots dissolving microneedles for methotrexate delivery to treat rheumatoid arthritis

Glycyrrhizic acid modified Poria cocos polyscaccharide carbon dots dissolving microneedles for methotrexate delivery to treat rheumatoid arthritis

Development and evaluation of sildenafil/glycyrrhizin-loaded nanofibers as a potential novel buccal delivery system for erectile dysfunction

Targeted Delivery of Nanoparticle-Conveyed Neutrophils to the Glioblastoma Site for Efficient Therapy

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