Pulmonary cryptococcal infection presenting with multiple lung nodules

Abstract

Pulmonary infections from the environmental fungus Cryptococcus gattii (C. gattii) are notable for cryptococcomas, which are usually solitary and can be very large. As with infections with Cryptococcus neoformans (C. neoformans) patients can have concomitant cryptococcal meningitis; however, unlike for C. neoformans, infections with C. gattii often occur in immunocompetent patients. The highest published incidence of C. gattii infection has been in the Indigenous Australian population of Arnhem Land in the tropical north of the country. More recently C. gattii has been responsible for outbreaks of cryptococcosis in the Pacific Northwest of Canada and the United States of America (USA). A previously healthy Indigenous male from Arnhem Land presented with pulmonary cryptococcosis with chest imaging showing >50 bilateral lung nodules. This unusual occurrence was attributed to probable inhalation of fungal elements from prior use of a high-pressure leaf blower to clear eucalyptus and other debris in a remote bush camp.

Comparison of features and outcomes between HIV‐negative patients with Cryptococcus gattii meningitis and Cryptococcus neoformans meningitis in South China

“…Brain cryptococcoma can cause obstructive hydrocephalus via a mass effect, 23 and our data showed hydrocephalus occurred in 11.8% of CGM patients and 18.8% of CNM patients, which were less common than those in an Australian‐population‐based study, where 32%–35.3% of CGM patients experienced hydrocephalus 24 . Furthermore, we observed that meningeal enhancement and pulmonary cryptococcomas occurred more frequently in CGM patients, which consistent with current report 25 . However, the incidence rates of lung cryptococcomas (71.4% in VGI and 20% in VGII) in CGM patients here differ somewhat from those in Australia (47%), 14 British Columbia (66.4% in VGII), 12 and the United States (29–42% in VGII and 61% in VGI or VGIII) 20,22 .…”

“…24 Furthermore, we observed that meningeal enhancement and pulmonary cryptococcomas occurred more frequently in CGM patients, which consistent with current report. 25 However, the incidence rates of lung cryptococcomas (71.4% in VGI and 20% in VGII) in CGM patients here differ somewhat from those in Australia (47%), 14 British Columbia (66.4% in VGII), 12 and the United States (29-42% in VGII and 61% in VGI or VGIII). 20,22 Of note, less parenchymal lesions were observed in CGM, which may explain why focal neurologic impairment were less common.…”

Epidemiology, management and outcomes of Cryptococcus gattii infections: A 22-year cohort

“…11 people included in other case series descriptions [1,4,5,11,12] were also included in this study.…”

Diferentes Técnicas De Extração Da Própolis Vermelha De Alagoas: Rendimento E Análise De Compostos Fenólicos

“…A formação de nódulos e massas de infiltração pulmonar estão relacionados com sítios de latência e, consequentemente de disseminação das leveduras diante de uma predisposição do hospedeiro, como vulnerabilidade imunológica. No entanto, em pacientes imunocompetentes, apesar de ser associada com achados radiológicos atípicos e/ou agressivos, os sintomas desaparecem gradualmente após o tratamento (XIE et al, 2015;BASNAYAKE et al, 2018;SUWATANAPONGCHED et al, 2013).…”