Pulmonary collectins in innate immunity of the lung

Kuroki, Yoshio; Takahashi, M.; Nishitani, Chiaki

doi:10.1111/j.1462-5822.2007.00953.x

Cited by 168 publications

(132 citation statements)

References 77 publications

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“…1 Collectin/antigen-presenting cell interactions have significant functional consequences in infections and inflammatory diseases [2][3][4] and serve 2 main functions: pathogen clearance and modulation of innate immune cells. 5 Compelling evidence was provided to support the importance of SP-A and SP-D in innate immune function by studies on gene-deficient mice.…”

Section: Tnf; Sp-d; Dendritic Cell; Mouse Model; Airway Inflammationmentioning

confidence: 99%

Surfactant protein D inhibits TNF-α production by macrophages and dendritic cells in mice

Hortobagyi

Kierstein

Krytska

et al. 2008

Journal of Allergy and Clinical Immunology

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Section: Tnf; Sp-d; Dendritic Cell; Mouse Model; Airway Inflammationmentioning

confidence: 99%

Surfactant protein D inhibits TNF-α production by macrophages and dendritic cells in mice

Hortobagyi

Kierstein

Krytska

et al. 2008

Journal of Allergy and Clinical Immunology

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“…Fascin is an actin cross- linking protein involved in the assembly of actin filaments into bundles (33). Finally, calreticulin is a multifunctional protein that serves as a cell-surface receptor for the C1q component of complement and mediates phagocytosis upon binding to major plasma proteins (34,35). Although the number of actin transcripts was similar in Vibrio-and SSW-injected oysters, all other three genes had a significantly higher number of transcripts in LGP32-injected oysters (P < 0.1) (Fig.…”

Section: Expression Of Cell Remodeling Genes Is Ompu-dependent In Lgp32mentioning

confidence: 99%

Use of OmpU porins for attachment and invasion of Crassostrea gigas immune cells by the oyster pathogen Vibrio splendidus

Duperthuy

Schmitt

Garzón

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

155

168

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OmpU porins are increasingly recognized as key determinants of pathogenic host Vibrio interactions. Although mechanisms remain incompletely understood, various species, including the human pathogen Vibrio cholera, require OmpU for host colonization and virulence. We have shown previously that OmpU is essential for virulence in the oyster pathogen Vibrio splendidus LGP32. Here, we showed that V. splendidus LGP32 invades the oyster immune cells, the hemocytes, through subversion of host-cell actin cytoskeleton. In this process, OmpU serves as an adhesin/invasin required for β-integrin recognition and host cell invasion. Furthermore, the major protein of oyster plasma, the extracellular superoxide dismutase CgEcSOD, is used as an opsonin mediating the OmpU-promoted phagocytosis through its RGD sequence. Finally, the endocytosed bacteria were found to survive intracellularly, evading the host defense by preventing acidic vacuole formation and limiting reactive oxygen species production. We conclude that (i) V. splendidus is a facultative intracellular pathogen that manipulates host defense mechanisms to enter and survive in host immune cells, and (ii) that OmpU is a major determinant of host cell invasion in Vibrio species, used by V. splendidus LGP32 to attach and invade oyster hemocytes through opsonisation by the oyster plasma Cg-EcSOD.T he oyster pathogen, Vibrio splendidus strain LGP32 was isolated from massive mortality events in the production of Crassostrea gigas oysters (1). However, up to now, little has been known about the route of infection and pathogenic processes of LGP32 (2, 3). A metalloprotease has been associated with toxicity (4, 5) and the outer membrane protein (OMP) OmpU was shown to be a major determinant of LGP32 virulence (6).As bacterial surface components, OMPs are both used by hosts for pathogen recognition and by pathogens for interaction with and invasion of host cells, serving as adhesion proteins (adhesins)

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“…Pulmonary surfactant also plays an important role on the innate immune system by enhancing pathogen clearance and by regulating immune-cell functions (3).…”

mentioning

confidence: 99%

Surfactant protein B and A concentrations are increased in neonatal pneumonia

et al. 2015

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Background: Term newborns with pneumonia show a reduced pulmonary compliance due to multiple and illdefined factors. Surfactant proteins' (SPs) changes could have a role in the reduced compliance but the matter is still unsettled. The aim of this study was to clarify the meaning of SPs changes during pneumonia in term newborns. Methods: In 28 term ventilated newborns, 13 with pneumonia and 15 with no lung disease, we measured SP-B, SP-A, disaturated-phosphatidylcholine (DSPC), and total phospholipids (PL) concentrations in tracheal aspirates at intubation and close to extubation. We also measured DSPC kinetics using (U-13 C-PA)dipalmitoyl-phosphatidylcholine. results: At baseline, SP-B, expressed as % of PL, was significantly different between the groups, being 3.5-fold higher in pneumonia than controls. Conversely, SP-A did not vary between the groups. At extubation, SP-B and SP-A concentrations had decreased significantly in newborns with pneumonia, while there was no significant change in controls. DSPC t 1/2 was significantly shorter in the pneumonia group (11.8 (5.5-19.8) h vs. 26.6 (19.3-63.6) h, P = 0.011). conclusion: In term newborns with pneumonia, SP-B increases with respect to PL, and DSPC is turned over at a faster rate. Disease's resolution is associated with the restoration of the normal ratio between SP-B and PL.

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Pulmonary collectins in innate immunity of the lung

Cited by 168 publications

References 77 publications

Surfactant protein D inhibits TNF-α production by macrophages and dendritic cells in mice

Surfactant protein D inhibits TNF-α production by macrophages and dendritic cells in mice

Use of OmpU porins for attachment and invasion of Crassostrea gigas immune cells by the oyster pathogen Vibrio splendidus

Surfactant protein B and A concentrations are increased in neonatal pneumonia

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