Pulmonary changes and cor pulmonale in mucoviscidosis

Wentworth, Paul; Gough, J.; Wentworth, James E.

doi:10.1136/thx.23.6.582

Cited by 26 publications

(5 citation statements)

References 10 publications

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“…The similar findings on CT imaging using SALD score in vivo and later ex vivo also validate the complex technique of lung processing. Likewise, our findings in CF are in agreement with previous histology information of mainly peribronchial disease and the patchy distribution throughout the lung (7,9,(34)(35)(36). Even with 40 years between the obtained samples, and with a vastly different treatment regimen, these main features are still prominently present.…”

Section: Discussionsupporting

confidence: 92%

Morphometric Analysis of Explant Lungs in Cystic Fibrosis

Boon¹,

Verleden

Bosch³

et al. 2016

Am J Respir Crit Care Med

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Section: Discussionsupporting

confidence: 92%

Morphometric Analysis of Explant Lungs in Cystic Fibrosis

Boon¹,

Verleden

Bosch³

et al. 2016

Am J Respir Crit Care Med

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“…Airway disease in CF is characterised by mucus plugging, chronic infection and an excessive inflammatory response, leading to peripheral airway changes in the first few months of life [101][102][103][104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119]. The characteristic airway abnormalities are bronchiectasis, thickening of the airway wall and mucus plugging [97,103,107,[120][121][122][123][124][125][126], as shown in figure 5.…”

Section: Airway Imaging In Cystic Fibrosismentioning

confidence: 99%

Computed tomographic imaging of the airways: relationship to structure and function

Jong

Müller²,

Paré³

et al. 2005

European Respiratory Journal

156

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Alterations in the structure of the airways, collectively termed airway remodelling, contribute to airflow obstruction in a variety of chronic lung diseases. While histology has provided valuable insights into the structure of airway wall remodelling, this technique is invasive and does not allow the longitudinal analysis of airway wall dimensions. Technical advances in computed tomography allow the assessment of airway wall dimensions, and are ideally suited for the noninvasive investigation of the pathogenesis of airway wall remodelling and the evaluation of new therapeutic interventions. The aim of this article is to review the use of computed tomography in the investigation of airway structure and function in health and disease.

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“…In young children, CF is primarily a disease of small airways. Pathologic studies of the lungs of young children with CF reveal small airways characterized by mucus obstruction, decreased number (density), and bronchiolectasis (10)(11)(12)(13)(14)(15)(16). Examination of the bronchoalveolar lavage fluid in children with CF suggests inflammation in the distal regions of the lung (17,18).…”

mentioning

confidence: 99%