Pulmonary capillary hemangiomatosis: A clinicopathologic review

Eltorky, Mahmoud; Headley, A. Stacey; Winer-Muram, Helen T.; Garrett, H. Edward; Griffin, John P.

doi:10.1016/0003-4975(94)90595-9

Cited by 75 publications

(65 citation statements)

References 12 publications

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“…In this condition, new capillary-sized, thin-walled blood vessels grow in the lung interstitium and in and around pulmonary blood vessels and airways. Pulmonary capillary haemangiomatosis is associated with pulmonary hypertension and pulmonary veno-occlusive disease [21], and has been described after radiation therapy and anti-oestrogen therapy in a patient with breast cancer [22]. On light microscopic sections ( fig.…”

Section: Discussionmentioning

confidence: 99%

Human alveolar capillaries undergo angiogenesis in pulmonary veno-occlusive disease

Schraufnagel

Sekosan²,

McGee³

et al. 1996

Eur Respir J

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H Hu um ma an n a al lv ve eo ol la ar r c ca ap pi il ll la ar ri ie es s u un nd de er rg go o a an ng gi io og ge en ne es si is s i in n p pu ul lm mo on na ar ry y v ve en no o--o oc cc cl lu us si iv ve e d di is se ea as se e ABSTRACT: The bronchial circulation undergoes angiogenesis in several pathological conditions, such as lung neoplasm and bronchiectasis, but whether the pulmonary circulation can do this has been questioned. A woman treated with mitomycin C and 5-fluorouracil developed progressive, fatal pulmonary hypertension over 5 months. In addition to light and transmission electron microscopic examination of her lung, her pulmonary vasculature was cast and the casts were studied with scanning electron microscopy.Light microscopy showed that she had pulmonary veno-occlusive disease and angiomatoid capillary growth in the alveolar walls. Transmission electron microscopy confirmed the presence of pulmonary hypertension and showed thickened endothelial basement membrane. Scanning electron microscopy of the cast blood vessels showed distortion and destruction of alveolar capillaries prohibiting the passage of erythrocytes. Large new capillaries developed on top of, and were connected to, the shrivelled capillaries that made up the alveolar wall. The new capillaries were larger and fewer, which reduced the alveolar-capillary interface. Arteries and veins were irregularly narrowed and the veins had broad muscularity. Oedema was present, and the pulmonary lymphatics were extensively cast, especially in the lobular septa, but the lymphatics had a normal appearance.It appears that this patient suffered extensive capillary damage and venous occlusion and that the response was extensive new capillary formation, sometimes in angiomatoid configurations, and hypertrophy of pulmonary veins and arteries. Casting the microvasculature and viewing it with scanning electron microscopy identified new alveolar capillaries in this patient with acquired pulmonary hypertension.

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Section: Discussionmentioning

confidence: 99%

Human alveolar capillaries undergo angiogenesis in pulmonary veno-occlusive disease

Schraufnagel

Sekosan²,

McGee³

et al. 1996

Eur Respir J

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“…Prognosis of PCH is poor because it is characteristically associated with pulmonary hypertension or veno-occlusive disease. 1) On the other hand, solitary pulmonary capillary hemangioma (SPCH), named by Fugo, is a rare disease that is characterized by a good prognosis because it is not associated with a specific clinical disorder. 2) To our knowledge, only a few cases of SPCH in infants and 7 cases in adults have been reported.…”

Section: Discussionmentioning

confidence: 99%

A Resected Case of Solitary Pulmonary Capillary Hemangioma Showing Pure Ground Glass Opacity

Sakaguchi

Isowa

Tokuyasu

et al. 2014

Ann Thorac Cardiovasc Surg

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A 53-year-old Japanese woman was referred to our hospital for pure ground glass opacity (GGO) in the left upper lung on computed tomography. 18F-fluorodeoxyglucose positron emission tomography revealed no abnormal uptake in the lesion. After 4 months of follow-up, we strongly suspected the lesion to be a bronchioloalveolar carcinoma and decided to perform a surgery for diagnosis. Planning to perform lingual segmentectomy by videoassisted thoracic surgery (VATS) with mini thoracotomy, we finally performed the left upper lobectomy to guarantee the optimal margin by VATS, because the lesion was not identified by palpation. Final pathological diagnosis was a solitary pulmonary capillary hemangioma (SPCH). We herein report a resected case of SPCH showing pure GGO and review all reported SPCH cases.

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“…esclerosis venosa marcada, es una característica histopatológica distintiva. 8 En la radiografía de tórax, se muestra un patrón micronodular difuso. 12 El trasplante ortotópico de corazón-pulmón o de doble pulmón es considerado como la única alternativa terapéutica, 12,13 aunque algunos informes de caso parecen sugerir éxito terapéutico con interferón e inhibidores de angiogénesis, tales como la doxiciclina.…”

Section: Figura 3: Biopsia Pulmonarunclassified

“…7 La presentación más común es la progresión lenta de HTP asociada a disnea de esfuerzo, cor pulmonale y, en última instancia, falla cardíaca derecha. 8 Recientemente, se ha informado HCP sin HTP concomitante. 9 También puede ocurrir con hemoptisis y derrame pleural.…”

Section: Introductionunclassified

Hemangiomatosis capilar pulmonar congénita en un recién nacido

et al. 2017

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Presentación de casos clínicosResumen La hemangiomatosis capilar pulmonar es una entidad poco frecuente, caracterizada por la proliferación de capilares que infiltran paredes alveolares, septos interlobulillares, pleura e intersticio pulmonar, sin características de malignidad, con asociación casi constante a hipertensión pulmonar. Hasta el momento, solo se han reportado en la literatura, dos casos de presentación congénita; este es el tercer caso en un recién nacido y que no se asocia a hipertensión pulmonar. Esta se encuentra en la mayoría de los pacientes con dicha patología, con mayor incidencia entre los 20 y los 40 años de edad. Se presenta a un recién nacido pretérmino de 36 semanas de gestación con dificultad respiratoria progresiva, que requirió asistencia ventilatoria mecánica por desaturaciones constantes en su evolución clínica, sin signos clínicos, radiológicos o ecográficos de hipertensión pulmonar. Palabras clave: hemangiomatosis capilar pulmonar, congénita, hipertensión pulmonar. AbstRActPulmonary capillary hemangiomatosis is a rare entity characterized by the proliferation of capillaries into alveolar walls, interlobular septa, pleura and pulmonary interstitium, without malignant characteristics, with almost constant association with pulmonary hypertension. Until now two cases of congenital presentation have been reported in the literature. This is the third case in a newborn; he has not followed the usual pattern associated with pulmonary hypertension as occurs in most patients with this pathology; the highest incidence is among 20-40 years old. Hemangiomatosis capilar pulmonar congénita en un recién nacido Congenital pulmonary capillary hemangiomatosis in a newbornWe report a preterm newborn patient of 36 weeks of gestation with progressive respiratory distress requiring mechanical ventilation by constant desaturation during his clinical evolution without clinical, radiological or ultrasonographic signs of pulmonary hypertension.

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Pulmonary capillary hemangiomatosis: A clinicopathologic review

Cited by 75 publications

References 12 publications

Human alveolar capillaries undergo angiogenesis in pulmonary veno-occlusive disease

Human alveolar capillaries undergo angiogenesis in pulmonary veno-occlusive disease

A Resected Case of Solitary Pulmonary Capillary Hemangioma Showing Pure Ground Glass Opacity

Hemangiomatosis capilar pulmonar congénita en un recién nacido

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