Pulmonary Blood Volume and Pulmonary Capillary Blood Volume in Valvular Heart Disease

Abstract

Measurements of pulmonary blood volume (PBV) and pulmonary capillary blood volume (V,) and hemodynamic studies were made in a series of 106 patients with valvular heart disease (62 with predominant mitral lesions and 44 with predominant aortic lesions). The results were compared with the data obtained from 14 "normal" patients and nine normal subjects. In 14 "normal" patients, the PBV varied from 204 to 315 m/m2 with a mean value of 269 ml/m2, while in nine "normal" patients and nine normal subjects the V, ranged from 39 to 66 mI/M2 with a mean value of 54 mI/M2. ADDITIONAL INDEXING WORDS: AngiocardiogramPhonocardiogram Indicator-dilution curves Hemodynamic studies ESTIMATES of total pulmonary blood volume (PBV) and pulmonary capillary blood volume (V,) have been reported separately in many patients with valvular heart disease.'-10 To our knowledge, there has been no report in the literature concerning the determination and comparison of these two variables in a large group of patients. The purpose of this paper is (1) to report the results of the determintaion of both PBV and V, in a series of 106 patients with valvular heart disease compared with those obtained from a group of 14 patients with normal hemodynamics and nine normal subjects and (2) to relate these two variables to cardiac output, pulmonary vascular pressures, and resistance in these patients.

Relations of Pulmonary Diffusing Capacity to Ventilation and Haemodynamics in Healthy Subjects

“…We, however, in healthy subjects did not find any correlation between DLCO and PAR, and assume that PAR is no factor determining DLC0 in healthy subjects. Yu [ 1967] found, in healthy subjects at rest, a constant ratio between total pulmonary and pulmonary capillary blood volumes (the examinations, however, were not performed simultaneously). No correlations are described between DLCOand central blood volume (CB V) during exercise.…”

Acute Saline Infusion Reduces Alveolar-Capillary Membrane Conductance and Increases Airflow Obstruction in Patients With Left Ventricular Dysfunction

“…In patients with mitral stenosis, DLCO has been partitioned into its constituent parts: alveolarcapillary membrane conductance (DM) and reactive conductance ⅐ Vc (where is the rate of chemical reaction of CO with Vc, the volume of pulmonary capillary blood available for gas transfer). 12 The reduction in DLCO and DM in this patient group correlates with NYHA functional class 12 and the severity of histological lung damage. 13 Moreover, pulmonary gas transfer may remain abnormal for up to 8 years after mitral valve replacement, 14 further supporting the hypothesis that a reduction of DM may reflect structural damage of the alveolar-capillary interface.…”

Influence of Pulmonary Hypertension on Pulmonary Diffusing Capacity in Patients with Mitral Stenosis

“…During exercise, both varia bles even did not change in the same direc tion in all instances. Whereas in healthy subjects the ratio between total pulmonary blood volume and pulmonary capillary blood volume is constant [Gazioglu and Yu, 1967], in patients with mitral stenosis this all instances. Nevertheless, there exist re ports on a correlation between pulmonary capillary filling and pulmonary blood vol ume in patients with mitral stenosis [Bjure et al, 1967;Yu, 1969], The discrepancy be tween our results and data in the literature may be partly explained by the fact that we did not measure pulmonary but central blood volume.…”