Pulmonary blastoma — a rare tumor with variable presentation

Adluri, Rajeshwara Krishna Prasad; Boddu, Srikanth; Martin-Ucar, Antonio E.; Duffy, John P.; Beggs, F D; Morgan, William E.

doi:10.1016/j.ejcts.2005.11.035

Cited by 36 publications

(24 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study of 5 patients with CBPB by Liman et al between 1987 and 2000 demonstrated long-term survival obtained by radical surgery in patients who have small size tumor (<5 cm) without nodal involvement [20]. Another study of 7 patients between 1993 and 2004 by Adluri et al showed similar long-term survival by radical surgery in stage T2N0M0 [26]. Local recurrence has been treated successfully with surgery in a few cases [8].…”

Section: Discussionmentioning

confidence: 89%

Classic biphasic pulmonary blastoma: A case report and review of the literature

et al. 2011

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 89%

Classic biphasic pulmonary blastoma: A case report and review of the literature

et al. 2011

View full text Add to dashboard Cite

“…In our patient, on the basis of the presence of two important prognostic factors the biphasic pattern of the disease on IHC and the large size of the tumor on X-ray chest (PA view) and computed tomography of thorax, patient was planned for adjuvant chemotherapy following resection of the tumor. Although the long term survival of the patient with PB have been reported in several individual case reports, but the overall prognosis of the patient with PB remain to be poor, [8]. In one survey of 83 patients with PB, approximately mean survival of 33 months was reported in those patients where negative margin was achieved during surgical excision of the tumor, [8].…”

Section: Discussionmentioning

confidence: 99%

“…Although the long term survival of the patient with PB have been reported in several individual case reports, but the overall prognosis of the patient with PB remain to be poor, [8]. In one survey of 83 patients with PB, approximately mean survival of 33 months was reported in those patients where negative margin was achieved during surgical excision of the tumor, [8].…”

Section: Discussionmentioning

confidence: 99%

Classic Biphasic Pulmonary Blastoma in an Adult Patient

2016

IJSR

View full text Add to dashboard Cite

Pulmonary blastoma (PB) is a disease of early childhood. We have reported here a case of classic biphasic pulmonary blastoma (CBPB) in a young adult patient. This is intended at highlighting the fact, that PB occurs in adult individuals, though not a very common occurrence. Thus, high index of suspicion with typically well-defined radiological images may help in clinching diagnosis, though histopathological examination with immunohistochemical evaluation may establish the diagnosis at an early stage, which may be crucial in successful management of such cases.

show abstract

“…In one survey of 83 cases, the mean survival of approximately 33 months was reported for the patients who underwent surgery and achieved negative margins [13]. The factors contributing to the unfavorable prognosis are the biphasic type, tumor recurrence, metastatic disease on presentation, tumor size over 5 cm, and frequent lymph node involvement [14].…”

Section: Discussionmentioning

confidence: 99%

Classical Biphasic Pulmonary Blastoma: A Case Report

Zidane¹,

Arsalane²,

Elktaibi³

et al. 2016

Arch Pulmonol Respir Care

View full text Add to dashboard Cite

Pulmonary blastomas are a rare aggressive neoplasms comprising 0.25-0.5% of all primary lung tumors and portend a poor prognosis. Recent World Health Orgnisation (WHO) reclassifications separated well differentiated fetal adenocarcinoma and pleuropulmonary blastoma from classic biphasic pulmonary blastoma which is now among carcinomas with pleomorphic, sarcomatoid or sarcomatous elements. The clinical and radiologic features are nonspecific. Surgery is the standard treatment and the efficacy of adjuvant chemotherapy and radiotherapy has not yet been established. We present a case of classic biphasic pulmonary blastoma in a 52-year old male and review the literature.for left pleural tuberculosis treated in 1988. On examination he looked well, had no clubbing. Baseline investigations were done, which included complete blood count, renal function tests, and liver function tests; all were within the normal range. Chest X-ray showed a well-demarcated mass projected over the right hilum. A subsequent chest computed tomography scan with intra-venous contrast (Figures 1,2) confirmed a well-defined 3.8 × 2.5 cm mass arising from the medial segment of the middle lobe. It demonstrated heterogeneous contrast enhancement with few necrotic foci. The mass abutted the mediastinal pleura with no sign of invasion of left atrium. There was no evidence of lymphadenopathy. The liver and adrenal glands appeared normal. CT guided biopsy was done and the smear revealed a biphasic neoplasm composed of epithelial and mesenchymal components suggestive of pulmonary blastoma. CT abdomen and bone scintigraphy showed no evidence of distant metastasis. The patient underwent a middle lobectomy with hilar and mediastinal lymph node dissection. The histopathology of the specimen confirmed the diagnosis of pulmonary blastoma without involvement of the lymph nodes. Post-operative course was uneventful and the patient was discharged on the 4th postoperative day. Due to the lack of certain poor prognostic factors like tumor size IntroductionPulmonary blastomas are a rare aggressive neoplasms comprising 0.25-0.5% of all primary lung tumors. They display a biphasic histology with mesenchymal and epithelial components whose features mimic embryological lung tissues before 4 months gestation. Since the first report by Barrett & Barnard [1], in 1945, over a hundred cases of pulmonary blastoma are reported in the literature. They are currently subdivided in three categories: well differentiated fetal adenocarcinoma, pleuropulmonary blastoma and classic biphasic pulmonary blastoma (CBPB). Surgery is the standard treatment and the efficacy of adjuvant chemotherapy and radiotherapy has not yet been established. We present a new case of this rare lung cancer. ObservationA 52-year-old man presented to the outpatient department with right chest pain of 3 months duration. He denied hemoptysis, dyspnea, fever or weight loss. His past medical history was significant

show abstract

Pulmonary blastoma — a rare tumor with variable presentation

Abstract: Pulmonary blastomas are rare tumors but can present with differing clinical features. Early detection and treatment may improve prognosis. Further larger series are needed to evaluate the characteristics of the tumor.

Cited by 36 publications

References 7 publications

Classic biphasic pulmonary blastoma: A case report and review of the literature

Classic biphasic pulmonary blastoma: A case report and review of the literature

Classic Biphasic Pulmonary Blastoma in an Adult Patient

Classical Biphasic Pulmonary Blastoma: A Case Report

Contact Info

Product

Resources

About