Pulmonary Benign Metastasizing Leiomyoma: a Report of Two Cases

Abstract

Benign metastasizing leiomyoma (BML) is a rare pathological process associated with pelvic leiomyoma. We present two cases of BML that are associated with giant pulmonary metastasis. BML is a rare benign metastatic phenomenon that could easily be mistaken for malignant neoplasms. Both cases occurred in middle-aged women who presented with cough and dyspnea. They previously underwent hysterectomy for uterine leiomyoma. After history taking, computed tomography, integrated PET/computed tomography and pathological assessment, a multidisciplinary treatment was offered for the diagnosis of BML. Physicians should consider BML among the differential diagnoses in women of reproductive age with a history of uterine leiomyoma presenting with pulmonary nodules, and accurate histopathological analysis should be made.

Incidental detection of benign metastasizing leiomyoma in asymptomatic female

“…[ 1 ] Since this 1939 report, numerous case reports have shown BML to cause pulmonary symptoms and complications including pneumothoraces. [ 3 , 8 ] Several theories have been proposed for the pathogenesis of BML, including hematogenous spread through peritoneal seeding during hysterectomy. While some evidence has been found in support of hematogenous spread, the validity of seeding during hysterectomy seems less certain.…”