Pulmonary aspiration

Ribaudo, Charles A.; Grace, William J.

doi:10.1016/0002-9343(71)90339-1

Cited by 48 publications

(9 citation statements)

References 38 publications

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“…Solid food in the gastric contents can caUSe obstruction of large airways, which may then lead to disruption of gas exchange from atelectasis as well as postobstructive pneumonia [6]. These solid substances must be removed quickly before this process occurs.…”

Section: What We Aspiratementioning

confidence: 99%

“…Mineral oil is occasionally used as a cathartic, and aspiration of this substance causes an inflammatory process that can perpetuate itself. Over the years it can grow into a masslike lesion within the lung and be mistaken for a tumor [6]. Aspiration of mineral oil may also predispose to the development of nontuberculous mycobacterial infections in the lung.…”

Section: ~8mentioning

confidence: 99%

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Pulmonary consequences of aspiration

Terry

Fuller

1989

Dysphagia

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Aspiration can lead to serious pulmonary disease and occasionally death. Substances aspirated commonly include bacteria or gastric contents or both, but may be as unusual as diesel oil or a variety of foreign bodies. Pulmonary symptoms range from a subtle cough, wheezing, or hoarseness to severe dyspnea or asphyxiation. We discuss the mechanism of pulmonary disease caused by aspiration as well as the appropriate treatment.

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Section: What We Aspiratementioning

confidence: 99%

Section: ~8mentioning

confidence: 99%

Pulmonary consequences of aspiration

Terry

Fuller

1989

Dysphagia

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“…Aspiration pneumonia is a common clinical problem in patients undergoing surgical procedures, in children with gastroesophageal reflex, and in immunocompromised hosts (1)(2)(3). The aspirated acid causes a focal lung injury and an inflammatory response.…”

mentioning

confidence: 99%

Role of CD11b in Focal Acid–induced Pneumonia and Contralateral Lung Injury in Rats

Motosugi

Quinlan

Bree

et al. 1998

Am J Respir Crit Care Med

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Neutrophil emigration in response to acid aspiration does not require the adhesion complex, CD11/ CD18. This study examined the role of CD11b/CD18 using the anti-CD11b F(ab')2, 1B6, in focal HCI-induced intracapillary neutrophil sequestration and edema formation within rat lungs, as well as the effect of pretreatment with endotoxin on this injury. The results show that at the site of aspiration pneumonia, anti-CD11b F(ab')2 did not inhibit neutrophil sequestration or edema formation, either with or without endotoxin pretreatment. In the contralateral lung, focal HCI aspiration induced neutrophil sequestration that was inhibited by the anti-CD11b F(ab')2, but no edema formation. The combined effect of endotoxin pretreatment and HCI aspiration induced CD11b/CD18-independent edema formation in the contralateral lung. These data indicate that CD11b/CD18-independent pathways mediate neutrophil sequestration and edema formation at that pneumonic site with or without pretreatment with endotoxin. CD11b/CD18 mediates neutrophil sequestration at distant sites when no endotoxin is present, although this CD11b/CD18-dependent sequestration is not association with edema formation. The combined effects of endotoxin and HCI aspiration induce edema formation at distant sites that could not be prevented by inhibiting the function of the CD11b/CD18 prior to aspiration.

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“…The right bronchial tree receives aspirated objects twice as frequently as the left because it branches from the trachea at a less acute angle. 41 The sectioned surface of the lung showed extensive bronchiectasis (Fig. 4).…”

Section: Dr Robert H Cleveland's Diagnosismentioning

confidence: 97%