Pulmonary Aspergillosis in People with Cystic Fibrosis

Abstract

In the last decade, fungal respiratory diseases have been increasingly investigated for their impact on the clinical course of people with cystic fibrosis (CF), with a particular focus on infections caused by Aspergillus spp. The most common organisms from this genus detected from respiratory cultures are Aspergillus fumigatus and Aspergillus terreus, followed by Aspergillus flavus, Aspergillus niger, and Aspergillus nidulans. These species have been identified to be both chronic colonizers and sources of active infection and may negatively impact lung function in people with CF. This review article discusses definitions of aspergillosis, challenges in clinical practice, and current literature available for laboratory findings, clinical diagnosis, and treatment options for pulmonary diseases caused by Aspergillus spp. in people with CF.

Risk factors for survival after lung transplantation in cystic fibrosis: impact of colonization with multidrug-resistant strains of Pseudomonas aeruginosa

“…Co-colonization with Aspergillus fumigatus appeared to be a negative predictor for survival after LUTX in patients with CF. Previous studies have shown that the combined colonization with P. aeruginosa and Aspergillus fumigatus is associated with a poor prognosis [ 20 , 25 , 26 ]. Particularly colonization with A. fumigatus may carry a significant risk to develop invasive aspergillosis [ 20 , 25 , 26 ].…”

“…Previous studies have shown that the combined colonization with P. aeruginosa and Aspergillus fumigatus is associated with a poor prognosis [ 20 , 25 , 26 ]. Particularly colonization with A. fumigatus may carry a significant risk to develop invasive aspergillosis [ 20 , 25 , 26 ]. Several studies showed that the infection with BCC is associated with poor prognosis and high mortality risk after LUTX.…”

Risk factors for survival after lung transplantation in cystic fibrosis: impact of colonization with multidrug-resistant strains of Pseudomonas aeruginosa

“…Co-colonization with Aspergillus fumigatus appeared to be a negative predictor for survival after LUTX in patients with CF. Previous studies have shown that the combined colonization with P. aeruginosa and Aspergillus fumigatus is associated with a poor prognosis [ 20 , 25 , 26 ]. Particularly colonization with A. fumigatus may carry a significant risk to develop invasive aspergillosis [ 20 , 25 , 26 ].…”

“…Previous studies have shown that the combined colonization with P. aeruginosa and Aspergillus fumigatus is associated with a poor prognosis [ 20 , 25 , 26 ]. Particularly colonization with A. fumigatus may carry a significant risk to develop invasive aspergillosis [ 20 , 25 , 26 ]. Several studies showed that the infection with BCC is associated with poor prognosis and high mortality risk after LUTX.…”

Efficacy of Liposomal Amphotericin B in Treating Pulmonary Aspergillus flavus Infection in Nonneutropenic Adults: Cases Report and Literature Review

“…Invasive aspergillosis primarily affects the lungs, typically presenting with symptoms such as fever, chest pain, and hemoptysis, along with chest CT findings of patchy infiltrates, nodules that may cavitate, macronodules, or patchy consolidation [ 7 ]. Reviewing articles published in recent years on pulmonary A. flavus infections, the majority of cases reported involve immunocompromised adults and children [ 8 , 9 , 10 ], with limited studies conducted in animal models [ 11 , 12 ]. There were no reports about its use in treating pulmonary A. flavus infections in nonimmunocompromised adults.…”

Risk factors for survival after lung transplantation in cystic fibrosis: impact of colonization with multidrug-resistant strains of Pseudomonas aeruginosa

“…Co-colonization with Aspergillus fumigatus appeared to be a negative predictor for survival after LUTX in patients with CF. Previous studies have shown that the combined colonization with P. aeruginosa and Aspergillus fumigatus is associated with a poor prognosis [ 20 , 25 , 26 ]. Particularly colonization with A. fumigatus may carry a significant risk to develop invasive aspergillosis [ 20 , 25 , 26 ].…”

“…Previous studies have shown that the combined colonization with P. aeruginosa and Aspergillus fumigatus is associated with a poor prognosis [ 20 , 25 , 26 ]. Particularly colonization with A. fumigatus may carry a significant risk to develop invasive aspergillosis [ 20 , 25 , 26 ]. Several studies showed that the infection with BCC is associated with poor prognosis and high mortality risk after LUTX.…”

Efficacy of Liposomal Amphotericin B in Treating Pulmonary Aspergillus flavus Infection in Nonneutropenic Adults: Cases Report and Literature Review

“…Invasive aspergillosis primarily affects the lungs, typically presenting with symptoms such as fever, chest pain, and hemoptysis, along with chest CT findings of patchy infiltrates, nodules that may cavitate, macronodules, or patchy consolidation [ 7 ]. Reviewing articles published in recent years on pulmonary A. flavus infections, the majority of cases reported involve immunocompromised adults and children [ 8 , 9 , 10 ], with limited studies conducted in animal models [ 11 , 12 ]. There were no reports about its use in treating pulmonary A. flavus infections in nonimmunocompromised adults.…”

Risk factors for survival after lung transplantation in cystic fibrosis: impact of colonization with multidrug-resistant strains of Pseudomonas aeruginosa

“…Co-colonization with Aspergillus fumigatus appeared to be a negative predictor for survival after LUTX in patients with CF. Previous studies have shown that the combined colonization with P. aeruginosa and Aspergillus fumigatus is associated with a poor prognosis [ 20 , 25 , 26 ]. Particularly colonization with A. fumigatus may carry a significant risk to develop invasive aspergillosis [ 20 , 25 , 26 ].…”

“…Previous studies have shown that the combined colonization with P. aeruginosa and Aspergillus fumigatus is associated with a poor prognosis [ 20 , 25 , 26 ]. Particularly colonization with A. fumigatus may carry a significant risk to develop invasive aspergillosis [ 20 , 25 , 26 ]. Several studies showed that the infection with BCC is associated with poor prognosis and high mortality risk after LUTX.…”

Efficacy of Liposomal Amphotericin B in Treating Pulmonary Aspergillus flavus Infection in Nonneutropenic Adults: Cases Report and Literature Review

“…Invasive aspergillosis primarily affects the lungs, typically presenting with symptoms such as fever, chest pain, and hemoptysis, along with chest CT findings of patchy infiltrates, nodules that may cavitate, macronodules, or patchy consolidation [ 7 ]. Reviewing articles published in recent years on pulmonary A. flavus infections, the majority of cases reported involve immunocompromised adults and children [ 8 , 9 , 10 ], with limited studies conducted in animal models [ 11 , 12 ]. There were no reports about its use in treating pulmonary A. flavus infections in nonimmunocompromised adults.…”