2011
DOI: 10.1183/09059180.00001011
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Pulmonary aspergillosis: a clinical review

Abstract: Aspergillus is a mould which may lead to a variety of infectious, allergic diseases depending on the host's immune status or pulmonary structure. Invasive pulmonary aspergillosis occurs primarily in patients with severe immunodeficiency. The significance of this infection has dramatically increased with growing numbers of patients with impaired immune state associated with the management of malignancy, organ transplantation, autoimmune and inflammatory conditions; critically ill patients and those with chronic… Show more

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Cited by 562 publications
(612 citation statements)
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References 259 publications
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“…16,31 For this reason, identifying individuals with Af sensitization with or without ABPA is important to ensure appropriate and timely therapeutic intervention to minimize pulmonary impact. 30 In this study we focused on the basophil activation marker CD203c as an indicator of Af sensitization and assessed its effect on important clinical measures of CF disease.…”
Section: Discussionmentioning
confidence: 99%
“…16,31 For this reason, identifying individuals with Af sensitization with or without ABPA is important to ensure appropriate and timely therapeutic intervention to minimize pulmonary impact. 30 In this study we focused on the basophil activation marker CD203c as an indicator of Af sensitization and assessed its effect on important clinical measures of CF disease.…”
Section: Discussionmentioning
confidence: 99%
“…Las manifestaciones clínicas pulmonares de la infección por este agente, no difieren de las que se presentan con A. fumigatus (7,10). Dichas manifestaciones se han agrupado en cuatro sín-dromes clínicos: aspergilosis pulmonar invasiva, aspergilosis necrótica crónica, también llamada aspergilosis semiinvasiva, aspergiloma y aspergilosis broncopulmonar alérgica (11).…”
Section: Discussionunclassified
“…En este caso, la paciente presentaba síntomas de aspergilosis invasiva, como neutropenia prolongada, tos persistente, lesiones nodulares en los exámenes radiológicos, antígeno galactomanano positivo en suero y, en la biopsia, invasión por debajo de la membrana basal en el árbol bronquial (10,11,13). Además, en la fibrobroncoscopia se observaron masas endobronquiales, que pueden presentarse en el aspergiloma endobronquial, el cual es más común en pacientes inmunocompetentes con lesiones pulmonares preexistentes y que, en cambio, es infrecuente en aquellos con aspergilosis pulmonar invasiva.…”
Section: Discussionunclassified
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“…Aspergillus infection may disseminate haematogenously to brain resulting in seizures, meningitis, epidural abscesses, ring-enhancing lesions, cerebral infarctions, and intracranial haemorrhage [25] . Involvement of other organs such as pleura, skin, oesophagus, liver, heart and kidneys are also reported [32] .…”
Section: Pa)mentioning
confidence: 99%