Pulmonary asbestos body counts and electron probe analysis of asbestos body cores in patients with mesothelioma. A study of 25 cases

Roggli, Victor L.; McGavran, Malcolm H.; Subach, J. A.; Sybers, Harley D.; Greenberg, Donald

doi:10.1002/1097-0142(19821201)50:11<2423::aid-cncr2820501130>3.0.co;2-i

Cited by 76 publications

(15 citation statements)

References 30 publications

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“…The range of values for malignant mesothelioma and pulmonary fibrosis is similar to those reported in other series (Roggli et al, 1982;Roggli and Pratt, 1983;Roggli, 1990). Asbestos bodies were identified in four of the five cases of pulmonary fibrosis, although there was considerable variation in the asbestos fibre counts.…”

Section: Discussionsupporting

confidence: 87%

“…This is becoming increasingly controversial, as it is now apparent that mesothelioma can develop following a prolonged latent period after low-level or brief exposure (Lanphear and Buncher, 1992). Furthermore, asbestos fibre levels of mesothelioma cases are known to overlap with background levels of the general population (Roggli et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

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Interobserver Variability in Analysis of Asbestos Fibres and Asbestos Bodies in Human Lung Tissue

et al. 2004

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Two different methods of quantifying asbestos fibre burden were assessed and the counts obtained were compared with semi-quantitative asbestos body counts in corresponding tissue sections. Comparison of the two methods found significantly different asbestos fibre counts between specimens. Each technique showed wide limits of agreement for reproducibility and interobserver variability as assessed by Bland-Altman plots, such that a repeated count could not necessarily be expected to lie within the same exposure category. Asbestos body counts in tissue sections were reproducible with good correlation between observers. Asbestos body and asbestos fibre counts showed correlation in some samples but not others. Counting of asbestos bodies is a valuable screening technique as the finding of asbestos bodies is accepted as a marker of significant asbestos exposure. When no asbestos bodies are identified asbestos fibres estimations may be useful in proving asbestos exposure. Different techniques are not interchangeable and each laboratory should establish a background range from unexposed individuals.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Interobserver Variability in Analysis of Asbestos Fibres and Asbestos Bodies in Human Lung Tissue

et al. 2004

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“…Hematogenous dissemination to distant organs is an event that rarely becomes clinically evident during the course of the disease. However, distant metastases of pleural MM occur and have been histologically documented in brain, meninges, lymph nodes, liver, kidney, lung, skin, bone, oral cavity, and large intestine [1,[6][7][8][9]. Autopsy studies have demonstrated the presence of distant metastases in up to 50% of patients with MM, including a case with multiple nodules in the skeletal muscles of the extremities [2].…”

Section: Discussionmentioning

confidence: 99%

Soft Tissue Metastasis as Initial Manifestation of Pleural Malignant Mesothelioma

Laurini¹,

Castiglioni²,

Elsner³

et al. 1999

Int J Surg Pathol

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Distant metastases of pleural malignant mesothelioma (MM) are infrequent. We report a case of MM that presented as a skeletal muscle metastasis. This type of presentation has not been previously reported. A 38-year-old male complained about a mass in his right forearm. The tumor showed the histologic pattern, immunohistochemical phenotype, and ultrastructural features of an MM. In the clinical work-up, the x-ray film and computed tomography scan demonstrated pleural effusion and diffuse pleural thickening in the right hemithorax. The pleural biopsy showed an epithelial MM. The patient died from local progression of the disease 6 months after the diagnosis. No other distant metastases were clinically evident. Our case shows the importance of including MM in the differential diagnosis of metastatic neoplasms in skeletal muscle and the usefulness of ancillary techniques in the diagnosis of mesothelial neoplasms. Int J Surg Pathol 7(1): [39][40][41][42][43][44] 1999 Pleural malignant mesothelioma (MM) usually presents with chest pain and pleural effusion. Chest roentgenograms and computed tomography (CT) scans show diffuse and irregular pleural thickening in the affected hemithorax. The tumor has a locally aggressive behavior, which accounts for most of its morbidity and mortality. Autopsy studies have revealed the presence of distant metastases, although clinically evident metastases are rare manifestations of this neoplasm [1].We report a metastatic MM presenting as a skeletal muscle mass in a patient without a previously diagnosed pleural tumor. This type of pre-

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“…Types of asbestos fibers were determined using a transmission electronmicroscope with content of metals being analyzed by an x-ray analyzer. The relative peak heights for seven elements: magnesium, silicon, calcium, sodium, manganese, iron, and aluminum were measured for each fiber 9,10) . Values for the relative peakheight percentage of these seven elements were plotted on a Gibbs triangular coordinate diagram.…”

Section: Methodsmentioning

confidence: 99%

Malignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure

et al. 2004

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Malignant pleural mesothelioma is induced by asbestos exposure. Many reports have described this situation in America and European countries, but a few have been published in Japan. In this study malignant pleural mesothelioma cases in hospitals located in an area facing the Seto Inland Sea were evaluated. A total of 106 patients were examined with 100 patients having had occupational exposure to asbestos and 6 patients without such histories of asbestos exposure. Ninety seven were male and 9 were female. Ages ranged from 41 to 87 yr with mean of 64.8 ± 5.3 yr. Thirty seven cases showed epithelial type of tumor, 25 biphasic type and 15 showed sarcomatous. The remaining 23 cases had insufficient evidence for typing the tumor. The mean survival rate for all cases was 9.2 ± 11.6 months. Fifty-one patients had occupational histories of shipyard work, 16 patients worked in asbestos cement piping, and the remainder were employed in miscellaneous jobs related asbestos exposure. The duration of asbestos exposure ranged up to 20 yr or longer with the mean of 17.2 ± 8.9 yr and the average latent period for the occurrence of malignant pleural mesothelioma was more than 31 yr with the mean of 37.0 ± 13.3 yr. Quantification of asbestos bodies in the lungs indicated a high concentration in most patients and the major types of asbestos fibers were crocidolite and amosite. Six cases appeared after exposure to chrysotile. These results indicated that ninety four percent of malignant pleural mesothelioma appeared due to the exposure to asbestos including crocidolite and amosite. The remainder may be blamed on exposure to chrysotile.

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Pulmonary asbestos body counts and electron probe analysis of asbestos body cores in patients with mesothelioma. A study of 25 cases

Cited by 76 publications

References 30 publications

Interobserver Variability in Analysis of Asbestos Fibres and Asbestos Bodies in Human Lung Tissue

Interobserver Variability in Analysis of Asbestos Fibres and Asbestos Bodies in Human Lung Tissue

Soft Tissue Metastasis as Initial Manifestation of Pleural Malignant Mesothelioma

Malignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure

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