Pulmonary artery thrombus associated with the ductus arteriosus

Left Pulmonary Artery Thrombosis in a Neonate with Left Lung Hypoplasia

“…In the majority of the reports PAT developed already in utero. The thrombus originated in several reports from fetal DA [4–6], similar to our case, where ductal origin of the thrombus was documented both with echocardiography and preoperatively. This entity may occasionally remain unrecognized and untreated; however, in most cases PAT presents as respiratory failure [3], severe persistent pulmonary hypertension of the newborn, or cyanotic congenital heart disease [8].…”

Patent ductus arteriosus endarteritis in a 40-year old woman, diagnosed with Transesophageal Echocardiography. A case report and a brief review of the literature

“…The most common complications of this congenital disease are left heart failure and ductus IE, while pulmonary artery IE[6] and aorta or/and PA thrombosis [7] have been reported. PDA is a common cause of CHF in newborns.…”

Ductus arteriosus‐associated infective endarteritis: Lessons from the past, future perspective

“…A PDA-IE was previously defined by the presence of a PDA associated to typical vegetation (echocardiography guarantees enough imaging quality for the diagnosis 20 ) or positive blood cultures. 37 In accordance to our S. aureus bacteremia, bacterial pathogens for PDA-IE are mainly Streptococcus spp., Staphylococcus spp., and very rarely Gram-negative rods.…”

“…According to our literature review (Table ), the typical presentation of a PDA‐IE is characterized by prolonged fever (for weeks or even months), sometimes associated to clinical signs of an hemodynamic relevant PDA (fatigue, heart failure, anorexia) or of complications of a PDA‐IE such as septic pulmonary or systemic embolisms. Most case reports include patients with an isolated PDA, not associated with other types of CHD or previous cardiac surgery, except one case, where the PDA‐IE involves the pulmonary valve.…”

“…The ductus arteriosus Botalli connects the descending aortic arch with the roof of the main and left pulmonary artery and serves as an obligatory right‐to‐left shunt during fetal life. Since first successful surgical ligation of a patent ductus arteriosus (PDA) in 1938 and the establishment of medical and interventional techniques for PDA closure, infective endarteritis in patients with a PDA is a rare or even disappearing clinical entity in developed countries and only described in cases reports and one retrospective study with vegetations related to hemodynamic relevant or less relevant PDA found either in postmortem studies or echocardiographic evaluations. However, in developing countries a PDA remains a predisposing risk factor for IE …”