Pulmonary artery leiomyosarcoma: A clinical dilemma

Demirci, Nilgün Yılmaz; Naurzvai, Nurgul; Kırbaş, İsmail; Akyürek, Nalân; Gürsel, Gül; Öztürk, Can

doi:10.4103/lungindia.lungindia_137_17

Cited by 5 publications

(15 citation statements)

References 8 publications

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“…Autopsy studies indicate that leiomyosarcomas constitute <1% of all malignant cardiac neoplasms and only 8-9% of all cardiac sarcomas. Cardiac leiomyosarcoma typically presents in the fourth decade [1][2][3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Overall, right atrial neoplasms are more likely to be malignant than left atrial tumors which are usually myxomas. However, as our cases illustrated, leiomyosarcoma favors the left atrium and tends to invade the pulmonary veins and mitral valve [2,[6][7][8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…It is important to acknowledge when this clinical presentation persists even after anticoagulation therapy in a patient without risk factors for thromboembolism [8,9]. Additional symptoms have been described such as palpitations, syncope, weight loss, and cough [6,9,12,13]. However, when they present with pericardial effusion, they may present clinical characteristics of cardiac tamponade (dyspnea, tachypnea, peripheral edema, angina, low arterial blood pressure, tachycardia, tachypnea, chest discomfort, jugular venous pressure elevated, and muffled heart sounds), like our cases.…”

Section: Discussionmentioning

confidence: 99%

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Acute Cardiac Tamponade Secondary to Cardiac Vascular-Type Pleomorphic Leiomyosarcoma: Case Report

et al. 2021

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Soft tissue sarcomas represent <1% of all neoplasms. Leiomyosarcomas comprise only 5–7% of cases, and only 2% of these are vascular. Vascular leiomyosarcomas are extremely rare and represent only 0.001% of all neoplasms, the venous type being up to 5 times more frequent. Arterial leiomyosarcomas most frequently affect the great vessels, being fatal in most cases. In the reported cases of arterial leiomyosarcomas, the most frequently affected site is the pulmonary artery. We present the clinical case of 2 patients (a 42-year-old woman and a 36-year-old man) with a diagnosis of arterial pleomorphic leiomyosarcoma that conditioned cardiac tamponade as the initial manifestation. As it is an exceptionally rare neoplasm and with few cases reported in the literature, it is important to identify and describe this pathology which, due to the impossibility of offering surgical treatment, represents a therapeutic challenge.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Acute Cardiac Tamponade Secondary to Cardiac Vascular-Type Pleomorphic Leiomyosarcoma: Case Report

et al. 2021

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“…11). 48 Because pulmonary artery leiomyosarcomas are frequently intraluminal, they may be misinterpreted as pulmonary thromboembolism on CT imaging (Fig. 11).…”

Section: Pulmonary Artery Leiomyosarcomamentioning

confidence: 99%

Smooth Muscle Conditions of the Chest

McCann

Massoth

Rojas

et al. 2020

Journal of Thoracic Imaging

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Smooth muscle conditions of the chest have diverse clinical and imaging manifestations and may involve nearly every thoracic structure. Differentiation among these conditions requires the integration of clinical, radiologic, and histopathologic data. Histologic examination in conjunction with immunohistochemistry is essential for differentiation from other spindle cell neoplastic mimics. Familiarity with these entities will ensure the inclusion of smooth muscle conditions in the differential diagnosis of thoracic soft tissue lesions and potentially guide the clinician in appropriate management. We review the clinical, imaging, and histopathologic features of thoracic smooth muscle-related conditions organized by the anatomic structures affected.

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“…Among these, leiomyosarcomas comprise 21% of all pulmonary artery tumors, making them the most common primary pulmonary artery sarcomas (PPAS) [ 1 ]. Nevertheless, the overall incidence of primary pulmonary leiomyosarcomas accounts for only 0.2-0.5% of all lung primary lung malignancies [ 2 ]. Therefore, the diagnosis is seldom made timely due to the low index of suspicion, and its presentation is often mistaken for a more common diagnosis such as pulmonary artery thromboembolism [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Artery Root Replacement for Leiomyosarcoma: A Viable Thoracic Oncovascular Operation

Keita¹,

Janko²,

Peterman³

et al. 2022

Cureus

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Leiomyosarcoma of the pulmonary artery is a rare but potentially fatal disease. Due to its rarity, the treatment algorithm is not well-established. While there may be a role for both chemotherapy and radiotherapy, surgical management is the most definitive method. Unfortunately, when the disease process is advanced, surgery may not be curative. However, it may still be a palliative treatment option. In this case report, we present a patient who suffered from respiratory symptoms that were initially attributed to pulmonary embolism (PE). However, upon the diagnosis of pulmonary artery leiomyosarcoma (PAL), surgery intervention was undertaken and resulted in an improved quality of life for the patient.

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Pulmonary artery leiomyosarcoma: A clinical dilemma

Cited by 5 publications

References 8 publications

Acute Cardiac Tamponade Secondary to Cardiac Vascular-Type Pleomorphic Leiomyosarcoma: Case Report

Acute Cardiac Tamponade Secondary to Cardiac Vascular-Type Pleomorphic Leiomyosarcoma: Case Report

Smooth Muscle Conditions of the Chest

Pulmonary Artery Root Replacement for Leiomyosarcoma: A Viable Thoracic Oncovascular Operation

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