Changes in stroke volume variation (SVV) and pulse pressure variation (PPV) in response
to fluid infusion were experimentally evaluated during vecuronium infusion and sevoflurane
anesthesia in 5 adult, mechanically ventilated, euvolemic, beagle dogs. Sequential
increases in central venous pressure (CVP; 3–7[baseline], 8–12, 13–17, 18–22 and 23–27
mmHg) were produced by infusing lactated Ringer’s solution and 6% hydroxyethyl starch
solution. Heart rate (beats/min), right atrial pressure (RAP, mmHg), pulmonary arterial
pressure (PAP, mmHg), pulmonary capillary wedge pressure (PCWP, mmHg), transpulmonary
thermodilution cardiac output (TPTDCO, l/min), stroke volume (SV,
ml/beat), arterial blood pressure (ABP, mmHg), extravascular lung water
(EVLW, ml), pulmonary vascular permeability index (PVPI, calculated), SVV
(%), PPV (%) and systemic vascular resistance (SVR, dynes/sec/cm5) were
determined at each predetermined CVP range. Heart rate (P=0.019), RAP
(P<0.001), PAP (P<0.001), PCWP
(P<0.001), TPTDCO (P=0.009) and SV
(P=0.04) increased and SVR (P<0.001), SVV
(P<0.001) and PPV (P<0.001) decreased associated
with each stepwise increase in CVP. Arterial blood pressure, EVLW, PVPI and the arterial
partial pressures of oxygen and carbon dioxide did not change. The changes in SVV and PPV
directly reflected the fluid load and the minimum threshold values for detecting fluid
responsiveness were SVV ≥11% and PPV ≥7% in dogs.