Pulmonary Arterial Hypertension Emergency Complications and Evaluation

Hohsfield, Robin; Archer-Chicko, Christine; Housten, Traci; Nolley, Stephanie

doi:10.1097/tme.0000000000000210

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…18 , 19 IV and SC therapies place patients at increased risk of catheter occlusion, thrombosis, thromboembolism, infections, sepsis, and infusion site pain. 7 , 12 , 14 , 20 – 27 …”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and tolerability of LIQ861, a novel dry‐powder formulation of treprostinil

et al. 2020

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A dry-powder inhaled formulation of treprostinil (LIQ861) produced using PRINTÂ® technology offers a substantial advantage over current nebulized therapy. Treprostinil is a synthetic prostacyclin analogue that is currently approved for inhalation administration to patients with pulmonary arterial hypertension (PAH) via nebulized TyvasoÂ® inhalation solution. LTI-101 was a phase 1, placebo-controlled, double-blind, randomized, single-center study that evaluated the ascending single-dose pharmacokinetics (PK) of LIQ861 in healthy subjects. Six sequential, escalating doses (25, 50, 75, 100, 125, and 150 mcg) were studied to investigate treprostinil exposure from LIQ861 inhalation. Subjects (n=57) were randomly assigned in a 3:1 ratio to receive a single dose of either LIQ861 (n=43) or placebo (n=14); 56 subjects completed all protocol-defined assessments. Following single-dose administration, treprostinil exposure from LIQ861 increased proportionally across the dose range studied, and the PK profile of treprostinil administered as LIQ861 was similar to prior reports of inhaled treprostinil. All doses of LIQ861 were generally well-tolerated with no deaths, serious adverse events, or dose-limiting toxicities. The most frequently reported treatment-emergent adverse events (TEAEs) related to study drug administration were coughing and throat irritation, which are common to dry-powder formulations. Treatment-related TEAEs were reported more frequently at higher dose levels; however, all were assessed as mild in severity. We conclude that the PK profile of treprostinil using a dry-powder inhaled formulation increased in proportion to dose as anticipated and was similar to earlier reports of inhaled, nebulized treprostinil (TyvasoÂ®). Based on these results, a phase 3 study (INSPIRE; Clinicaltrials.gov Identifier NCT03399604) evaluating the long-term safety and tolerability of LIQ861 in patients with PAH was initiated.

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“…18 , 19 IV and SC therapies place patients at increased risk of catheter occlusion, thrombosis, thromboembolism, infections, sepsis, and infusion site pain. 7 , 12 , 14 , 20 – 27 …”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and tolerability of LIQ861, a novel dry‐powder formulation of treprostinil

et al. 2020

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“…The nurses must work holistically and involve the patient’s family and friends when possible [ 10 ]. In addition to the PH specialist centers, the patients will need contact with the primary care [ 13 ], the emergency department [ 14 ], and the municipality and social insurance services [ 4 ]. The PH nurse will be the focal point in this web of healthcare providers and authorities [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Insight into How Nurses Working at PH Specialist Clinics in Sweden Perceive Their Work

Ivarsson

Kjellström

2020

Healthcare

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Outpatient pulmonary hypertension (PH) specialist centers have an important role in the optimal management of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The aim of the present study was to gain an understanding of the work facing nurses at the outpatient PH specialist centers in Sweden. All nurses (n = 14) working at the outpatient PH specialist centers in Sweden were included. Qualitative content analysis was employed to analyze the interviews, wherein an overarching theme emerged: “Build and maintain a relationship with the patient”. Three categories described the nurses’ experiences: “Ambiguous satisfaction regarding information and communication”, “Acting as a coordinator” and “Professional and personal development”. To provide good patient care, the nurses described the key components as the ability to give information on all aspects of the disease and their availability by phone for patients, their relatives, and other healthcare resources. This requires evidence-based, specialist knowledge about the disease, its care, and treatments as well as experience. In conclusion, working as a nurse at the outpatient PH specialist centers highlight the advantages, expectations, and difficulties in working with patients with a rare and life-threatening illness. The overall knowledge and skills were high, but the nurses expressed a need for in-depth and continued training.

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Evaluation and management of pulmonary hypertension in the emergency department setting

Simon

Bridwell

Montrief

et al. 2020

The American Journal of Emergency Medicine

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Pulmonary Arterial Hypertension Emergency Complications and Evaluation

Cited by 3 publications

References 31 publications

Pharmacokinetics and tolerability of LIQ861, a novel dry‐powder formulation of treprostinil

Pharmacokinetics and tolerability of LIQ861, a novel dry‐powder formulation of treprostinil

Novel Insight into How Nurses Working at PH Specialist Clinics in Sweden Perceive Their Work

Evaluation and management of pulmonary hypertension in the emergency department setting

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