Pulmonary Arterial Hypertension Associated With Gastroesophageal Reflux in a 2-Month-Old Boy With Down Syndrome

Seki, Mitsuru; Kato, Tetsushi; Masutani, Satoshi; Matsunaga, Tamotsu; Senzaki, Hideaki

doi:10.1253/circj.cj-08-0993

Cited by 10 publications

(6 citation statements)

References 15 publications

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“…This is consistent with our previous report on a Down syndrome infant without structural cardiac anomaly [14]. Down syndrome is known to be associated with an increased prevalence of GER.…”

Section: Discussionsupporting

confidence: 93%

Duodenal Tube Feeding: An Alternative Approach for Effectively Promoting Weight Gain in Children with Gastroesophageal Reflux and Congenital Heart Disease

Kuwata

Iwamoto

Ishido

et al. 2013

Gastroenterology Research and Practice

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We tested whether duodenal tube feeding effectively improves the clinical symptoms and body weight gain in children with congenital heart disease (CHD) and gastroesophageal reflux (GER). In the retrospective analysis of 17 consecutive children with CHD who were treated with duodenal tube feeding for symptomatic GER, we found that clinical symptoms of persistent emesis or respiratory wheezing after feeding disappeared with duodenal tube feeding in all patients. Duodenal tube feeding facilitated a stable nutritional supply, resulting in marked improvement of weight gain from 6 to 21 g/day (P < .0001). In a patient with trisomy 21 and persistent pulmonary hypertension after the closure of a ventricular septal defect, duodenal tube feeding ameliorated pulmonary hypertension, as evidenced by the improvement of the pressure gradient of tricuspid regurgitation from 77 to 41 mm Hg. In 14 of the 17 patients, the duodenal tube was successfully removed, with the spontaneous improvement of GER (median duration of duodenal tube feeding: 7 months). In conclusion, duodenal tube feeding improves the weight gain of infants with GER who need treatment for CHD-associated heart failure. It also allows for the improvement of pulmonary hypertension.

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“…This is consistent with our previous report on a Down syndrome infant without structural cardiac anomaly [14]. Down syndrome is known to be associated with an increased prevalence of GER.…”

Section: Discussionsupporting

confidence: 93%

Duodenal Tube Feeding: An Alternative Approach for Effectively Promoting Weight Gain in Children with Gastroesophageal Reflux and Congenital Heart Disease

Kuwata

Iwamoto

Ishido

et al. 2013

Gastroenterology Research and Practice

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“…17 Approximately 50% of children with Down syndrome develop obstructive sleep apnea syndrome, which may contribute to the unexplained pulmonary hypertension associated with Down Syndrome. 18 Gastroesophageal reflux, pulmonary aspiration, and lower respiratory tract infections also increase the risk of pulmonary hypertension in these patients, 19 and it is possible that they contribute to the development of this complication after TCPC. A longterm follow-up study with a larger number of patients with Down syndrome is therefore required, and it is also necessary to further evaluate the outcome of TCPC in these patients.…”

Section: Discussionmentioning

confidence: 99%

Outcome of univentricular repair in patients with Down syndrome

Furukawa

Park

Yoshikawa

et al. 2013

The Journal of Thoracic and Cardiovascular Surgery

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“…Severe bronchopneumonia has also been associated with pulmonary hypertension (6), but our patient did not show any evidence of this on CXRs. Seki et al (7) reported the first association of severe gastroesophageal reflux and aspiration pneumonia with the development of pulmonary hypertension in a two-month-old boy with Down's syndrome (7). Our patient did not have clinically significant gastroesophageal reflux.…”

Section: Discussionmentioning

confidence: 46%

New‐Onset Neonatal Pulmonary Hypertension Associated with a Rhinovirus Infection

Patel

2012

Canadian Respiratory Journal

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A 3.5-week-old male neonate who developed an upper and lower respiratory tract rhinovirus infection that was temporally associated with the development of severe pulmonary hypertension is described. Rhinovirus has not previously been associated with pulmonary hypertension. This child developed severe pulmonary hypertension with right ventricular failure, requiring mechanical ventilation, nitric oxide inhalation and, eventually, extracorporeal membrane oxygenation.

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Pulmonary Arterial Hypertension Associated With Gastroesophageal Reflux in a 2-Month-Old Boy With Down Syndrome

Cited by 10 publications

References 15 publications

Duodenal Tube Feeding: An Alternative Approach for Effectively Promoting Weight Gain in Children with Gastroesophageal Reflux and Congenital Heart Disease

Duodenal Tube Feeding: An Alternative Approach for Effectively Promoting Weight Gain in Children with Gastroesophageal Reflux and Congenital Heart Disease

Outcome of univentricular repair in patients with Down syndrome

New‐Onset Neonatal Pulmonary Hypertension Associated with a Rhinovirus Infection

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