Pulmonary and Sinusal Changes in 45 Patients With Primary Immunodeficiencies

Bondioni, Maria Pia; Duse, Marzia; Plebani, Alessandro; Soresina, Annarosa; Notarangelo, Luigi D.; Berlucchi, Marco; Grazioli, Luigi

doi:10.1097/rct.0b013e31802e3c11

Cited by 32 publications

(31 citation statements)

References 18 publications

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“…There were no relationships between mucosal thickening or osteitis and gender. The high frequency of sinus mucosal thickening is consistent with the study of Bondioni et al [11], where 25 of 27 patients (93%) were found to have sinus mucosal thickening. Although these numbers likely represent referral bias of patients selected on the basis of upper respiratory symptoms, they do support the utility of sinus tomography in the documentation of sinus disease, which may be very helpful supporting evidence in the clinical diagnosis of patients with CVID.…”

Section: Discussionsupporting

confidence: 91%

“…Endoscopic findings of sinus disease have been reported [10]. Bondioni et al [11] are the only authors to date to describe the radiologic findings of CVID using computed tomography (CT) of the paranasal sinuses. However, the immunoglobulin values of the subjects were not provided in the report [11].…”

Section: Introductionmentioning

confidence: 99%

“…Bondioni et al [11] are the only authors to date to describe the radiologic findings of CVID using computed tomography (CT) of the paranasal sinuses. However, the immunoglobulin values of the subjects were not provided in the report [11]. Chee et al [12] reported results of immune tests in patients with refractory sinusitis in a tertiary care setting where 9.9% of subjects were found to have CVID.…”

Section: Introductionmentioning

confidence: 99%

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Reduced Immunoglobulin M Is Associated with Sinus Mucosal Thickening, Osteitis and Sinus Surgery in Patients with Common Variable Immunodeficiency

Hagan¹,

Park²,

Kita³

et al. 2009

Int Arch Allergy Immunol

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Background: Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition. Methods: We performed a retrospective review by a blinded observer using the Lund-Mackay numerical scoring scale as well as a visual scale for remodeling changes in the paranasal sinus bone on CT scans in CVID patients. Results: The sinus CT scans of 19 subjects (9 males, 10 females; median age at diagnosis 34 years) are described. There was an inverse relationship between serum IgM and sinus mucosal thickening as described by the Lund-Mackay scale (R = –0.6398; p = 0.0032). Osteitis of the paranasal sinus bone was almost exclusively found in patients with a reduced serum IgM level of less than 25 mg/dl (p = 0.0074). Conclusion: This is the first study to show that sinus mucosal thickening on CT in patients with CVID is inversely related to serum IgM levels.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reduced Immunoglobulin M Is Associated with Sinus Mucosal Thickening, Osteitis and Sinus Surgery in Patients with Common Variable Immunodeficiency

Hagan¹,

Park²,

Kita³

et al. 2009

Int Arch Allergy Immunol

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“…586,587 CVID, X-linked hypogammaglobulinemia, and several other disorders of humoral immunity are frequently referenced as contributing factors to chronic or recurrent recalcitrant RS. 15,588,589,[596][597][598][599] A number of selective Ig deficiencies, specifically those involving IgG3 subclass, IgA, and IgM, have been consistently identified in this group of patients. 585,586,590,593,594,[596][597][598][600][601][602] Preimmunization antipneumococcal titers have been shown to be decreased as well, particularly in patients with the more severe forms of immunodeficiency such as CVID.…”

Section: Discussionmentioning

confidence: 92%

“…The most common clinical manifestations of PID include chronic otitis media, RS, and chronic lung disease such as pneumonia and bronchiectasis. [585][586][587][588][589] An association between hypoimmunoglobulinemia and CRS has been described in the literature and multiple studies have demonstrated PID as a risk factor for the development of CRS. 15,155,[590][591][592][593][594][595][596] The association is further strengthened by other studies that show an increased incidence of RS in patients with immune dysfunction.…”

Section: Discussionmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

541

878

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Immunoglobulin replacement therapy reduces chronic rhinosinusitis in patients with antibody deficiency

Walsh

Gurrola

Graham

et al. 2016

Int Forum Allergy Rhinol

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Pulmonary and Sinusal Changes in 45 Patients With Primary Immunodeficiencies

Abstract: On computed tomography, the type and severity of lung lesions do not correlate either with the type of immunodeficiency or with the severity of the sinusal involvement.

Cited by 32 publications

References 18 publications

Reduced Immunoglobulin M Is Associated with Sinus Mucosal Thickening, Osteitis and Sinus Surgery in Patients with Common Variable Immunodeficiency

Reduced Immunoglobulin M Is Associated with Sinus Mucosal Thickening, Osteitis and Sinus Surgery in Patients with Common Variable Immunodeficiency

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Immunoglobulin replacement therapy reduces chronic rhinosinusitis in patients with antibody deficiency

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