Pulmonary and Hepatic Activities of Membrane-Bound
Enzymes in Man and Rat

Bodanszky, Hedwig; Greengard, Olga; Den, Tiberius

doi:10.1159/000459226

Cited by 6 publications

(4 citation statements)

References 4 publications

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“…Emphasizing even more strongly the broad validity of the principle of 'fetalism', this principle could be transferable to the human lung. Our results can be interpreted as based on the studies of Knox, [13,14], Greengard and Herzfeld [16] and Bodansky et al [18]. The latter [ 18] regarded that the enzymes AP and GGT in the lung increase drastically their activities with age.…”

Section: Resultssupporting

confidence: 71%

“…Our results can be interpreted as based on the studies of Knox, [13,14], Greengard and Herzfeld [16] and Bodansky et al [18]. The latter [ 18] regarded that the enzymes AP and GGT in the lung increase drastically their activities with age. Renal GGT also increases in the course of normal differentia tion of the kidney and after that, Hautman et al [19] demonstrated a decrease in the activ ity of GGT in the urine of patients with renal neoplasms.…”

Section: Resultssupporting

confidence: 71%

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Alkaline Phosphatase, Gamma-Glutamyl Transferase, Lactate Dehydrogenase and Creatine Kinase in Bronchial Aspirate from Neoplastic and Normal Pulmonary Tissue

Ruiz-Moral¹,

Pérez-Jiménez²,

Cosano³

et al. 1985

Enzyme

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The activities of 4 enzymes, i.e. alkaline phosphatase,γ-glutamyl transferase, lactate dehydrogenase and creatine kinase were studied in bronchial aspirates and serums from two groups of subjects, the first one was composed of 14 subjects without active bronchopulmonary pathology and the other of 20 patients with lung cancer. The results showed a statistically significant decrease of the activities of alkaline phosphatase and ß-glutamyl transferase in bronchial aspirate from patients with bronchogenic malignant tumors in relation to normal subjets. This finding could be explained by the ‘fetalism’ principle, which states that the quantitative pattern of enzymes of immature human tissues resembles those of neoplastic tissues.

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Section: Resultssupporting

confidence: 71%

Section: Resultssupporting

confidence: 71%

Alkaline Phosphatase, Gamma-Glutamyl Transferase, Lactate Dehydrogenase and Creatine Kinase in Bronchial Aspirate from Neoplastic and Normal Pulmonary Tissue

Ruiz-Moral¹,

Pérez-Jiménez²,

Cosano³

et al. 1985

Enzyme

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“…GGT expression is increased in whole lung after birth [10], but is decreased in adult liver compared to fetal liver [17]. GGT activity is increased in certain liver diseases, after stroke, in tumor tissues, and in other pathologies [18][19][20][21][22][23].…”

mentioning

confidence: 99%

4-Hydroxynonenal increases γ-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways

Zhang

Dickinson

Liu

et al. 2005

Free Radical Biology and Medicine

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Abstractγ-Glutamyl transpeptidase (GGT) plays key roles in the metabolism of glutathione. Previous studies have shown that GGT expression was increased by oxidants, but the mechanism remains unclear. In the present study, the effects of 4-hydroxy-2-nonenal (HNE), an electrophilic end product of lipid peroxidation, on GGT expression were investigated in rat lung epithelial type II (L2) cells. We demonstrated that HNE increased GGT activity and mRNA content in both time-and dose-dependent manners. Actinomycin D, an RNA transcription inhibitor, blocked HNE-stimulated increase in GGT mRNA, suggesting transcriptional regulation of GGT mRNA by HNE. Of the seven GGT mRNA transcripts known to be produced from the single rat GGT gene, we found that types I, II, and V-2 were constitutively expressed in L2 cells, but only types I and V-2 were increased by HNE. PD98059 and SB203580, relatively specific inhibitors of the ERK and the p38MAPK kinase pathway, respectively, significantly attenuated HNE induction of both GGT activity and mRNA content. In contrast, studies with JNK inhibitor I, a cell-permeable peptide, indicated that JNK was not involved in the GGT induction by HNE. We also found that GGT induction by HNE could be completely blocked by a cocktail of PD98059 and SB203580, suggesting a combined effect of ERK and p38MAPK pathways in HNE-mediated GGT induction. In conclusion, our results demonstrate that HNE increased GGT expression in rat alveolar type II cells and that the induction of GGT by HNE was mediated through activation of the ERK and p38MAPK pathways.

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“…The amounts of a chemical constituent, in contrast, can assume any number of values in a continuum. The very advantage of this quantitative method No. 3 ENZYME PATHOLOGY OF LUNG CA Greengard et al 46 1 may be lost if, in the necessary search for contrasts between histologically predefined groups of tumors, one fails to pay due attention to the chemical differences between individual tumors within one such group.…”

mentioning

confidence: 99%

Enzyme pathology and the histologic categorization of human lung tumors: The continuum of quantitative biochemical indices of neoplasticity

Greengard

Head

Goldberg

et al. 1982

Cancer

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The purpose of the present enzymic and histologic analysis of pulmonary samples from 39 subjects was to discern a common, meaningful pattern which may underlie the biochemical heterogeneity of lung neoplasms. The distribution among the different tumors of thymidine kinase, uridine kinase, phosphoserine phosphatase, hexokinase and adenylate kinase was found to correlate with each other. By averaging their standardized units (normal lung = 0) an enzymic index of neoplasticity was calculated for each tumor and used (in increasing order) to rank all 39. The index, showing a significant positive correlation with mitotic frequency, encompassed a continuous 100-fold range. Poorly differentiated carcinomas ranked high while neoplasms with better differentiation and prognosis placed in the lower half of the range. The results indicate that enzymes showing coordinated variations over a broad spectrum of tumors could contribute objective criteria to the rating of any individual tumor against a continuous, quantitative scale of neoplasticity.

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Pulmonary and Hepatic Activities of Membrane-Bound Enzymes in Man and Rat

Cited by 6 publications

References 4 publications

Alkaline Phosphatase, Gamma-Glutamyl Transferase, Lactate Dehydrogenase and Creatine Kinase in Bronchial Aspirate from Neoplastic and Normal Pulmonary Tissue

Alkaline Phosphatase, Gamma-Glutamyl Transferase, Lactate Dehydrogenase and Creatine Kinase in Bronchial Aspirate from Neoplastic and Normal Pulmonary Tissue

4-Hydroxynonenal increases γ-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways

Enzyme pathology and the histologic categorization of human lung tumors: The continuum of quantitative biochemical indices of neoplasticity

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