Pulmonary and extrapulmonary infection caused by <i>Mycobacterium conceptionense:</i> the first report from Iran

Shojaei, Hasan; Hashemi, Abodolrazagh; Heidarieh, Parvin; Ataei, Behrouz; Naser, Abass Daei

doi:10.1258/shorts.2010.010103

Cited by 10 publications

(11 citation statements)

References 8 publications

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“…As in our results, M. conceptionense clinical isolates in two other studies were susceptible to CLR (16,17). These findings suggest that M. conceptionense does not have a functional erm gene, but additional research is needed to determine whether this lack is a hallmark of the species.…”

supporting

confidence: 82%

Species Distribution and Macrolide Susceptibility of Mycobacterium fortuitum Complex Clinical Isolates

Kim

Moon

Jhun

et al. 2019

Antimicrob Agents Chemother

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The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum, M. porcinum, M. septicum, and M. conceptionense. Most M. fortuitum, M. porcinum, and M. septicum isolates were inducibly resistant to clarithromycin, whereas two-thirds of the M. peregrinum isolates were clarithromycin susceptible. Clarithromycin-resistant M. fortuitum isolates exhibited common mutations of erm(39), potentially involved in clarithromycin resistance.

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supporting

confidence: 82%

Species Distribution and Macrolide Susceptibility of Mycobacterium fortuitum Complex Clinical Isolates

Kim

Moon

Jhun

et al. 2019

Antimicrob Agents Chemother

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“…M. gordonae, which is also sometimes considered pathogenic [59], [60], [61], [62], [63], has been previously isolated from drinking water [43], [64] and was isolated in our study from water and biofilm samples. Other nontuberculous mycobacteria were also recovered in the present work, including M. conceptionense [65], [66], [67], [68], M. barrassiae [69] and M. neoaurum [70], [71], [72]. Finally, one of the two mycobacteria recovered within the amoeba H. vermiformis was M. iranicum.…”

Section: Discussionsupporting

confidence: 66%

Prevalence and diversity of Chlamydiales and other amoeba-resisting bacteria in domestic drinking water systems

Lienard

Croxatto

Gervaix

et al. 2017

New Microbes and New Infections

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A growing number of human infections incriminate environmental bacteria that have evolved virulent mechanisms to resist amoebae and use them as a replicative niche. These bacteria are designated amoeba-resisting bacteria (ARB). Despite the isolation of these ARB in various human clinical samples, the possible source of infection remains undetermined in most cases. However, it is known that the ARB Legionella pneumophila, for instance, causes a respiratory infection in susceptible hosts after inhalation of contaminated water aerosols from various sources. The Chlamydiales order contains many ARB, such as Parachlamydia acanthamoebae or Simkania negevensis, previously implicated in human respiratory infections with no identified contamination sources. We thus investigated whether domestic water systems are a potential source of transmission of these Chlamydiales to humans by using amoebal culture and molecular methods. Other important ARB such as mycobacteria and Legionella were also investigated, as were their possible amoebal hosts. This work reports for the first time a very high prevalence and diversity of Chlamydiales in drinking water, being detected in 35 (72.9%) of 48 investigated domestic water systems, with members of the Parachlamydiaceae family being dominantly detected. Furthermore, various Legionella and mycobacteria species were also recovered, some species of which are known to be causal agents of human infections.

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“…As a host factor, a disorder of the normal structure was dominant (post-operative, post-traumatic, lung diseases, and intravenous drug use). One previous bloodstream infection case (Case 4) was the result of intravenous drug use with HIV infection (6). Our patient's history was compatible with this previous case and had similar factors (CV port and chemotherapy for gastric carcinoma).…”

supporting

confidence: 74%

“…This organism was initially detected in 2006 (3). Until now, very few cases of definitive M. conceptionense infection have been reported (3)(4)(5)(6)(7)(8)(9)(10), and no Japanese cases have been published. Herein we describe the characteristics of M. conceptionense infection.…”

mentioning

confidence: 99%

<i>Mycobacterium conceptionense</i> Bloodstream Infection in a Patient with Advanced Gastric Carcinoma

et al. 2017

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SUMMARY:A 65-year-old Japanese male farmer with advanced gastric adenocarcinoma and multiple hepatic metastases was admitted to our hospital. Blood culture results were positive on day 5, and Gram-positive rods were detected. According to the results of Ziehl-Neelsen staining and a cultured colony of this bacterium, we suspected a mycobacterial infection. Suspecting a rapidly growing mycobacterium (RGM), we started multidrug therapy with levofloxacin, clarithromycin, and ethambutol, and the patient recovered from the bloodstream infection. Further gene examination (16S rRNA, hsp65, and sodA) revealed an isolate of Mycobacterium conceptionense. M. conceptionense was first identified as an RGM in 2006. Among previous case reports of M. conceptionense infections, bone and soft tissue infections in hosts with a disorder of the normal structure (e.g., surgical sites) were dominant. We report the characteristics of M. conceptionense infection in this first Japanese case report and a review of the literature.Non-tuberculous mycobacteria (NTM) are the causative pathogens in pneumonia, osteomyelitis, lymphadenitis, and bacteremia, particularly in immunocompromised hosts. The most common pathogens in Japan are Mycobacterium avium complex (MAC) (approximately 70-80z) and Mycobacterium kansasii (approximately 10-20z) (1); however, the prevalence of rapidly growing mycobacteria (RGM) is increasing.

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Pulmonary and extrapulmonary infection caused by Mycobacterium conceptionense: the first report from Iran

Cited by 10 publications

References 8 publications

Species Distribution and Macrolide Susceptibility of Mycobacterium fortuitum Complex Clinical Isolates

Species Distribution and Macrolide Susceptibility of Mycobacterium fortuitum Complex Clinical Isolates

Prevalence and diversity of Chlamydiales and other amoeba-resisting bacteria in domestic drinking water systems

<i>Mycobacterium conceptionense</i> Bloodstream Infection in a Patient with Advanced Gastric Carcinoma

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