Pulmonary Alveolar Phospholipoproteinosis Induced by Orasol Navy Blue Dust

Ballantyne, Bryan

doi:10.1177/096032719401301008

Cited by 7 publications

(4 citation statements)

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“…It has been investigated that even not only the degradation products of these dyes but also the synthetic precursors and intermediates could be highly dangerous due to their toxic and carcinogenic nature (Clarke and Anliker, 1980). The majority of dyes could be an origin of allergic reactions, eczema, skin dermatoses (Nikulina et al, 1995), affect the liver (Jaskot and Costa, 1994;Nikulina et al, 1995), the lungs (Ballantyne, 1994), the vascocirculatory system (Przybojewska, 1996), the reproductive system (Eastin et al, 1996;Nikulina et al, 1995) and the immune system (Ng, 1995). While dyes of aromatic structures (Clarke and Anliker, 1980), which contain azo linkage, amino or nitro groups are cancer causing (Dipple and Bigger, 1991) in experimental animals as well as for humans.…”

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confidence: 99%

Estimation of Para Red Dye in Chilli Powder and Tomato Sauces by a Simple Spectrophotmetric Method followed by Thin layer Chromatography

Mustafa¹,

Khan²,

Sultana³

et al. 2013

Journal of Applied Sciences and Environmental Management

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A number of grinded chilli powder samples and tomato sauce samples were collected from various localities of Karachi city. All the samples were estimated for the presence of para red which is an azo dye and more specifically belongs from the group of sudan dyes. According to the regulation of various governmental agencies its use in food is strictly prohibited because of its ability to form carcinogenic compounds. Although there were a number of sophisticated chromatographic methods for the estimation of this dye but we developed here a simple, convenient, expeditious spectrophotometric method followed by thin layer chromatography technique and compared the results by single point and multiple point external standard methods. On the basis of these results we also specify the localities of Karachi city where the contamination is more prominent. © JASEM

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Estimation of Para Red Dye in Chilli Powder and Tomato Sauces by a Simple Spectrophotmetric Method followed by Thin layer Chromatography

Mustafa¹,

Khan²,

Sultana³

et al. 2013

Journal of Applied Sciences and Environmental Management

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“…2 Alveolar fillings may occur secondary to excess surfactant production and desquamation of type II pneumocytes, impaired removal or degradation of alveolar phospholipid, or an abnormal type of surfactant (as seen in cystic fibrosis). 4,14,15 Many people with PAP have defective pulmonary macrophages with impaired chemotactic activity, decreased adhesiveness, decreased capacity to kill bacteria, and poor survival in tissue culture. 12,16,17 It is possible that these dysfunctions are secondary to overaccumulation of undigested materials in the cells, because macrophage function can be restored after the removal of the insoluble material.…”

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confidence: 99%

“…3 The disease is often idiopathic in human neonates but has been associated in adults with compromised immunity, hematologic malignancies and lymphoma, respiratory infections, and exposure to environmental inorganic materials such as quartz, silica, aluminum dust, cement dust, wood dust, and navy blue dust. 1,5,14,[19][20][21][22] PAP has been reported in members of the same family, suggesting a genetic basis. 23 PAP has been described in 2 forms: classic, or primary, PAP and secondary PAP, or alveolar phospholipidosis.…”

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Pulmonary Alveolar Proteinosis in a Dog

Silverstein

Greene

Gregory

et al. 2000

Veterinary Internal Medicne

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A 3½-year-old male Shih Tzu dog was examined by a referring veterinarian at the University of Georgia Veterinary Medical Teaching Hospital, Athens, GA, for chronic exercise intolerance since 6 months of age and coughing of 4 months' duration. The dog's medical history included mild seborrhea sicca and seasonal atopic dermatitis, treated with dietary modification and parenteral triamcinolone injections every 2-3 months. The dog had been treated with a 2-week course of tetracycline (15 mg/kg PO q8h) 3 months before examination for lethargy, fever, and weakness in conjunction with high serum immunoglobulin G titers to Borrelia burgdorferi (1,024; reference range, Ͻ256) and Rickettsia rickettsii (128; reference range, Ͻ64). The dog also received amoxicillin and clavulanate (20 mg/ kg PO q12h) for 10 days 4 months before referral and enrofloxacin (5 mg/kg, PO q12h) for 10 days 7 weeks before referral. No improvement was seen with any of these therapies. Hematologic abnormalities present during this time included a persistent neutrophilic leukocytosis with an inconsistent lymphocytosis and eosinophilia.At the time of referral, examination revealed the dog to be bright, alert, and responsive. Rectal temperature was slightly high (102.8ЊF [39.3ЊC]; reference range, 99.5-102.5ЊF [37.5-39.2ЊC]). The dog had a normal pulse rate (130 beats/min; reference range, 110-130 beats/min) and increases in respiratory rate (50 breaths/min; reference range, 15-30 breaths/min). Lung sounds were increased in intensity, and the dog had an easily induced dry, hacking cough.Abnormalities on hematologic testing included a leukocytosis (23.4 ϫ 10 3 cells/L; reference range, 5.1-13.0 cells/L) with a mature neutrophilia (18.3 ϫ 10 3 cells/L; reference range, 2.9-12.0 cells/L) and eosinophilia (2.1 ϫ 10 3 cells/L; reference range, 0.0-1.3 cells/L). Serum total protein (7.6 g/dL; reference range, 5.4-7.5 g/dL) and globulin concentrations (4.2 g/dL; reference range, 1.9-5.3 g/dL) were increased. Urinalysis was within normal limits. Fundic examination revealed no abnormalities. An interstitial lung pattern was seen on thoracic radiographs ( Fig 1A,B). No parasite ova were seen in feces examined by Sheather flotation or Baermann extraction. Cytologic findings of a transtracheal washing were of a moderate amount

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“…Side effects of oxime treatment in humans were monitored in 750 volunteers, and the main adverse effects reported were changes in blood pressure, pulse rate, dizziness, nausea and blurred vision 182,189 . Oral administration of oximes produces gastrointestinal distress 182 .…”

Section: Physiological Propertiesmentioning

confidence: 99%