Pulmonary Alveolar Microlithiasis

Shaw, Brian M.; Shaw, Steven D.; McCormack, Francis X.

doi:10.1055/s-0040-1702211

Cited by 9 publications

(5 citation statements)

References 54 publications

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“…[ 23 ] Moreover, etidronate interferes with phosphate incorporation into hydroxyapatite, culminating in reduced crystal formation. [ 24 ] The response to etidronate treatment has shown variable results. [ 25 ] Saito et al .…”

Section: Discussionmentioning

confidence: 99%

A case report of pulmonary alveolar microlithiasis with pulmonary tuberculosis

et al. 2023

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Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive disease characterised by the deposition of calcium phosphate microliths in the alveoli. PAM has been reported in all continents and there is often a familial history. There is clinical-radiological dissociation as there is often a paucity of symptoms in contrast to the imaging findings. Patients often remain asymptomatic until the third or fourth decade of life, and dyspnea is the most common symptom. PAM is caused by a mutation within the solute carrier family 34 member 2 gene (the SLC34A2 gene) located on chromosome 4p15.2, which encodes a sodium/phosphate co-transporter. The imaging appearance of the disease is quite pathognomic with the high-resolution computed tomography (HRCT) demonstrating a diffuse micronodular appearance. Transbronchial lung biopsy also confirms the diagnosis. There is no effective therapy at present except lung transplantation. We herein, present a case of PAM along with clinical history, imaging study, histopathological study and genetic study of a 43-year-old female adult patient along with genetic analysis.

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Section: Discussionmentioning

confidence: 99%

A case report of pulmonary alveolar microlithiasis with pulmonary tuberculosis

et al. 2023

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“…PAM is characterized by a defect in SLC34A2, a type IIb sodium-dependent phosphate cotransporter found in alveolar epithelial cells. Dysfunction of this transporter results in the failure to export inorganic phosphate from the alveolar lining fluid, leading to calcium accumulation and hydroxyapatite microlith formation [ 15 , 16 ]). On chest radiograph, PAM may exhibit diffuse or scattered micronodules, hyperdense infiltrates with a predilection for the lung bases, ground-glass attenuation, linear subpleural calcifications or subpleural nodules, small parenchymal nodules, dense consolidations, and a mosaic pattern of attenuation.…”

Section: Discussionmentioning

confidence: 99%

Metastatic pulmonary calcification on bone scintigraphy of a patient with lupus nephritis and end-stage renal disease

Cheng,

Li,

Cheng

2023

Radiology Case Reports

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“…The loss of this transporter function results in accumulation of inorganic phosphate in alveolar fluid, which binds to calcium to form calcium phosphate deposits. 81 82 The most common CT findings are ground-glass attenuation and linear and nodular subpleural calcifications ( Fig. 31 ).…”

Section: Pulmonary Alveolar Microlithiasismentioning

confidence: 99%

High-Resolution Computed Tomography of Nonfibrotic Interstitial Lung Disease

Marrocchio

Lynch

2022

Semin Respir Crit Care Med

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Nonfibrotic interstitial lung diseases include a heterogeneous group of conditions that can result in various patterns of lung involvement. When approaching the computed tomographic (CT) scan of a patient with a suspected or known interstitial lung disease, the use of the appropriate radiological terms and a systematic, structured approach to the interpretation of the imaging findings are essential to reach a confident diagnosis or to limit the list of differentials to few possibilities. The large number of conditions that cause nonfibrotic interstitial lung diseases prevents a thorough discussion of all these entities. Therefore, this article will focus on the most common chronic lung diseases that can cause these CT findings. A pattern-based approach is used, with a discussion of nodular pattern, consolidation, crazy paving, ground-glass opacities, septal thickening, and calcifications. The different clinical conditions will be described based on their predominant pattern, with particular attention to findings that can help in the differential diagnosis.

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Pulmonary Alveolar Microlithiasis

Cited by 9 publications

References 54 publications

A case report of pulmonary alveolar microlithiasis with pulmonary tuberculosis

A case report of pulmonary alveolar microlithiasis with pulmonary tuberculosis

Metastatic pulmonary calcification on bone scintigraphy of a patient with lupus nephritis and end-stage renal disease

High-Resolution Computed Tomography of Nonfibrotic Interstitial Lung Disease

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