Pulmonary alveolar microlithiasis

Devi, HJ Gayathri; Rao, KN Mohan; Prathima, K. M.; Das, Jayanth K

doi:10.4103/0970-2113.80334

Cited by 12 publications

(6 citation statements)

References 9 publications

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“…In India, this entity was first reported by Viswanathan et al 14 Very few cases have been reported in the literature from different regions of India and less than 60 autopsies depicted cases of PAM. [16][17][18][19][20] The entity generally has a slowly progressive course, leading to a higher rate of incidental detection during work-up for other illnesses, or at autopsy. There is no specific available treatment.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary alveolar microlithiasis: Incidental finding - should we Ignore?

2019

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Section: Discussionmentioning

confidence: 99%

Pulmonary alveolar microlithiasis: Incidental finding - should we Ignore?

2019

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“…[6] Not more than 30 cases are reported in literature from different regions of India till date. [7–11] We came across six cases of PAM during our chest practice at Shimla and all of them belonged to the hilly region of Himachal Pradesh. [1213]…”

Section: Epidemiologymentioning

confidence: 99%

Pulmonary alveolar microlithiasis

Kashyap

Mohapatra

2013

Lung India

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Pulmonary alveolar microlithiasis (PAM) is a rare, chronic lung disease with bilateral intra-alveolar calcium and phosphate deposition throughout the lung parenchyma with predominance to lower and midzone. Although, etiology and pathogenesis of PAM is not fully understood, the mutation in SLC34A2 gene that encodes a sodium-phosphate co-transporter in alveolar type II cells resulting in the accumulation and forming of microliths rich in calcium phosphate (due to impaired clearance) are considered to be the cause of the disease. Chest radiograph and high-resolution CT of thorax are nearly pathognomonic for diagnosing PAM. HRCT demonstrates diffuse micronodules showing slight perilobular predominance resulting in calcification of interlobular septa. Patients with PAM are asymptomatic till development of hypoxemia and cor-pulmonale. No therapy has been proven to be beneficial except lung transplantation.

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“…Not more than 30 cases are reported in literature from different regions of India till to date. 7 Pulmonary alveolar Microlithiasis occurs equally in both sexes 8 and in all age groups from new born to 80yrs, majority of them are diagnosed between 30-50 yrs.…”

Section: Epidemiologymentioning

confidence: 99%