Pulmonary allescheriasis. Report of a case and review of the literature

Arnett, Jerome C.

doi:10.1001/archinte.135.9.1250

Cited by 12 publications

(2 citation statements)

References 3 publications

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“…Chest radiographic findings varied from focal unilateral to bilateral diffused infiltrates and from nodules to bronchopneumonia. Numerous publications address the clinical manifestations of pulmonary P. boydii (16,160,258,259,327,387,407,455), Scedosporium apiospermum (73,126,233,304,351,390,432), and S. prolificans (35,170,204,233,257,265,354,470) infections. The symptoms include fever, productive cough, hemopthysis, rales, and rhonchi.…”

Section: Nonmycetoma Infectionsmentioning

confidence: 99%

Infections Caused byScedosporiumspp

et al. 2008

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SUMMARY Scedosporium spp. are increasingly recognized as causes of resistant life-threatening infections in immunocompromised patients. Scedosporium spp. also cause a wide spectrum of conditions, including mycetoma, saprobic involvement and colonization of the airways, sinopulmonary infections, extrapulmonary localized infections, and disseminated infections. Invasive scedosporium infections are also associated with central nervous infection following near-drowning accidents. The most common sites of infection are the lungs, sinuses, bones, joints, eyes, and brain. Scedosporium apiospermum and Scedosporium prolificans are the two principal medically important species of this genus. Pseudallescheria boydii, the teleomorph of S. apiospermum, is recognized by the presence of cleistothecia. Recent advances in molecular taxonomy have advanced the understanding of the genus Scedosporium and have demonstrated a wider range of species than heretofore recognized. Studies of the pathogenesis of and immune response to Scedosporium spp. underscore the importance of innate host defenses in protection against these organisms. Microbiological diagnosis of Scedosporium spp. currently depends upon culture and morphological characterization. Molecular tools for clinical microbiological detection of Scedosporium spp. are currently investigational. Infections caused by S. apiospermum and P. boydii in patients and animals may respond to antifungal triazoles. By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans.

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Section: Nonmycetoma Infectionsmentioning

confidence: 99%

Infections Caused byScedosporiumspp

et al. 2008

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“…Masses of P. boydii hyphae (fungus balls) have been found in lung cavities. 9 In immunocompromised persons, an invasive pulmonary disease similar to invasive pulmonary aspergillosis can be seen. P. boydii has also been reported as a cause of allergic bronchopulmonary disease (similar to allergic bronchopulmonary aspergillosis), 10 pleural space infection, lung abscess, and invasive sinusitis.…”

Section: Scedosporiummentioning

confidence: 99%

Rare and Emerging Fungal Pulmonary Infections

Varkey¹,

Perfect²

2008

Semin Respir Crit Care Med

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The frequency and diversity of serious fungal infections are increasing. Persons who are severely immunocompromised are particularly vulnerable to infection from unusual molds and yeasts that are often found naturally in the environment. Clinical manifestations from these unusual fungal infections range from colonization of airways to chronic localized lesions to acute invasive or disseminated disease. When present, rare and emerging fungi are often isolated from the respiratory tract during a severely immunosuppressed state, and diagnosis requires isolation and identification of the infecting organism. Histopathology is often required to differentiate tissue invasion from airway colonization. There are no diagnostic serologies, and radiological exams are not specific. Furthermore, many emerging opportunistic molds demonstrate in vitro resistance to the older azoles and amphotericin B. As a result, successful treatment may require adjunct surgical debridement and, when possible, reconstitution of the host immune system. Also, the newer triazoles such as voriconazole and posaconazole may be useful to treat some of these infections caused by rare and emerging molds.

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Hyalohyphomycosis

Padhye¹

1988

Laboratory Diagnosis of Infectious Diseases

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Pulmonary allescheriasis. Report of a case and review of the literature

Cited by 12 publications

References 3 publications

Infections Caused byScedosporiumspp

Infections Caused byScedosporiumspp

Rare and Emerging Fungal Pulmonary Infections

Hyalohyphomycosis

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