Pulmonary AL amyloidosis: A review and update on treatment options

Moy, Lindsay N.; Mirza, Mahum; Moskal, Blake; Asado, Nahren; Shah, Bhaven; Bitran, Jacob D.

doi:10.1016/j.amsu.2022.104060

Cited by 7 publications

(2 citation statements)

References 14 publications

(61 reference statements)

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“…ser fatais [16,17]. A amiloidose pulmonar pode se manifestar desde um achado incidental assintomático até uma doença respiratória crônica [14]. O quadro clínico do paciente pode ser explicado tanto pela DPOC quanto pela TBA.…”

Section: Relato De Casounclassified

Amiloidose traqueobrônquica com aparecimento de sintomas após infecção por COVID 19: um relato de caso

Martins,

Silva,

Meireles

et al. 2023

Braz. J. Implantol. Health Sci.

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A amiloidose refere-se a um espectro de doenças caracterizadas pelo acúmulo extracelular anormal de proteínas mal dobradas. Com etiologia incerta, sua apresentação varia de acordo com o órgão envolvido. Relatamos um caso de amiloidose traqueobrônquica em paciente ex-tabagista com exacerbação após infecção por Sars-Cov 2. Aqui revisamos as referências pertinentes a este assunto e discutimos as principais condutas para a amiloidose respiratória.

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Section: Relato De Casounclassified

Amiloidose traqueobrônquica com aparecimento de sintomas após infecção por COVID 19: um relato de caso

Martins,

Silva,

Meireles

et al. 2023

Braz. J. Implantol. Health Sci.

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“… 2 Pulmonary amyloidosis is frequently characterized by the AL amyloid subtype and can be located or associated with systemic involvement, presenting in a nodular, diffuse interstitial, or tracheobronchial pattern. 3 Nodular pulmonary amyloidosis (nodular amyloidoma) can appear incidentally in a chest radiologic diagnosis, it is often asymptomatic and also does not usually require surgical resection. The main differential diagnosis is lung cancer and the specific histological diagnosis must be established.…”

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confidence: 99%

Diagnostic of Nodular Pulmonary Amyloidosis With Electromagnetical Navigation Bronchoscopy (ENB) and Cryobiopsy

Pajares,

Rafecas-Codern,

Serra-Mitjà

et al. 2024

Open Respiratory Archives

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A Case of Recurrent Localized Pulmonary Nodular Light Chain Amyloidosis Treated with Daratumumab plus CyBorD

Raddell,

Ashraf,

Zhao

et al. 2024

Acta Haematol

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Introduction Nodular pulmonary amyloidosis (NPA) is a localized form of AL amyloidosis often found incidentally and typically has an indolent and benign disease course treated with resection or local excision. We present a patient with recurrent localized AL amyloidosis who required further treatment. Case Description A 63-year-old female with MGUS was found to have pulmonary AL amyloid on wedge resection and later had recurrence. The patient did not have signs of a clonal plasma cell proliferation or systemic AL amyloid. She was treated with Daratumumab, Cyclophosphamide, Bortezomib, and Dexamethasone. After initiation of treatment the patient has had significant hematologic and radiographic response. Conclusion The patient had nodular pulmonary amyloidosis recurrence with organ dysfunction without systemic disease. Because the presentation of recurrent pulmonary AL amyloidosis is rare there is no published evidence on treatment. However, the patient has had hematologic and radiographic improvement after initiating treatment with a systemic protocol.

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Pulmonary AL amyloidosis: A review and update on treatment options

Cited by 7 publications

References 14 publications

Amiloidose traqueobrônquica com aparecimento de sintomas após infecção por COVID 19: um relato de caso

Amiloidose traqueobrônquica com aparecimento de sintomas após infecção por COVID 19: um relato de caso

Diagnostic of Nodular Pulmonary Amyloidosis With Electromagnetical Navigation Bronchoscopy (ENB) and Cryobiopsy

A Case of Recurrent Localized Pulmonary Nodular Light Chain Amyloidosis Treated with Daratumumab plus CyBorD

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