Pulmonary Airways: 3-D Reconstruction From Multislice CT and Clinical Investigation

Fétita, Catalin; Prêteux, Françoise; Beigelman-Aubry, Cathérine; Greniér, Philippe

doi:10.1109/tmi.2004.826945

Cited by 114 publications

(76 citation statements)

References 21 publications

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“…The segmentation of structures from medical imaging data has received significant attention (19). The air in the conducting airways provides good contrast between that structure and the surrounding lung parenchyma and has resulted in a great deal of attention being directed toward the segmentation of the airways from clinical CT images (3,5,6,16,32,34,35,43). Several researchers have attempted to apply these same techniques to micro-CT images of small animals (2,13,29,30,33,36).…”

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confidence: 99%

Airway and pulmonary vascular measurements using contrast-enhanced micro-CT in rodents

Counter

Wang

Farncombe

et al. 2013

American Journal of Physiology-Lung Cellular and Molecular Phys

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Counter WB, Wang IQ, Farncombe TH, Labiris NR. Airway and pulmonary vascular measurements using contrast-enhanced micro-CT in rodents. Am J Physiol Lung Cell Mol Physiol 304: L831-L843, 2013. First published April 5, 2013 doi:10.1152/ajplung.00281.2012.-Preclinical imaging allows pulmonary researchers to study lung disease and pulmonary drug delivery noninvasively and longitudinally in small animals. However, anatomically localizing a pathology or drug deposition to a particular lung region is not easily done. Thus, a detailed knowledge of the anatomical structure of small animal lungs is necessary for understanding disease progression and in addition would facilitate the analysis of the imaging data, mapping drug deposition and relating function to structure. In this study, contrast-enhanced micro-computed tomography (CT) of the lung produced high-resolution images that allowed for the characterization of the rodent airway and pulmonary vasculature. Contrast-enhanced micro-CT was used to visualize the airways and pulmonary vasculature in Sprague-Dawley rats (200 -225 g) and BALB/c mice (20 -25 g) postmortem. Segmented volumes from these images were processed to yield automated measurements of the airways and pulmonary vasculature. The diameters, lengths, and branching angles of the airway, arterial, and venous trees were measured and analyzed as a function of generation number and vessel diameter to establish rules that could be applied at all levels of tree hierarchy. In the rat, airway, arterial, and venous tress were measured down to the 20th, 16th, and 14th generation, respectively. In the mouse, airway, arterial, and venous trees were measured down to the 16th, 8th, and 7th generation, respectively. This structural information, catalogued in a rodent database, will increase our understanding of lung structure and will aid in future studies of the relationship between structure and function in animal models of disease. computed tomography; contrast agents; pulmonary circulation; airway nomenclature THE LUNG IS A COMPLEX ORGAN that works dynamically and must react to changes in posture, environment, and disease (20). Its major function is gas exchange, bringing oxygen into the body while removing carbon dioxide. To accomplish this task, a well-coordinated interaction between the lung and pulmonary circulation is essential. The rodent lung is comprised of two branching networks: the airways and pulmonary vasculature. With the advent of small animal imaging systems, researchers are able to visualize these networks in situ and noninvasively study the progression of lung disease and assess drug efficacy in animal models of disease. Much of this research involves combining the anatomical data obtained using computed tomography (CT) with the functional data obtained using single photon emission computed tomography (SPECT) or positron emission tomography (PET). A detailed knowledge of the structure of the lung would facilitate the mapping of functional data relative to lung anatomy and thus further our understandi...

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mentioning

confidence: 99%

Airway and pulmonary vascular measurements using contrast-enhanced micro-CT in rodents

Counter

Wang

Farncombe

et al. 2013

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…The measure for the comparison is made using the Jaccard similarity index [58], also known as the Tanimoto coefficient which measures the overlap of two sets [57]. …”

Section: Experiments and Resultsmentioning

confidence: 99%

Implementation of Fuzzy Thresholding for Segmentation of Images

Kumari¹,

Enireddy²

2017

IJCA

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Segmentation is a process of dividing an image into multiple regions making it easier for the analysis. It is also an important step in Image processing. It also has number of applications which includes Medical field to analyze a disease, scientific fields including, engineering and technology, face recognition and object. Many algorithms and techniques have been developed for the image segmentation. To remove distinctive areas from a picture an immediate and straight forward method is using thresholding. It looks for a worldwide esteem that boosts the partition between yield classes. Noisy or uneven illuminated images pose a challenge for segmentation. The utilization of solitary hard limit esteem is absolutely the wellspring of imperative division mistakes in numerous situations like boisterous images or uneven illumination. In this paper a multiregion thresholding technique is displayed to overcome the normal downsides of thresholding strategies when images are debased with artifacts and commotion. Pixels from the images are related to various yield centroids by means of fuzzy membership function, evading any underlying hard choice. To make this strategy robust to noise and artifacts it utilizes spatial data through a local aggregation step where the participation level of every pixel is adjusted by neighborhood data that considers the enrollments of the encompassing pixels. The results are then compared with the existing techniques and results obtained are satisfactory.

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“…Once the set of axes is known, a "response function" is computed for each vessel slice from a vector rotating around the axis point and the intensity gradient. The voxel positions for which the response function is maximum give the vessel contour in the investigated slices when the axis is correctly determined [40].…”

Section: Image-based Computational Modelmentioning

confidence: 99%

Biofluid Flow and Heat Transfer

Thiriet¹,

Sheu²,

Garon³

2016

Handbook of Fluid Dynamics, Second Edition

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2nd EditionInternational audienceMajor moving biological fluids, or biofluids, are blood and air that cooperate to bring oxygento the body’s cells and eliminate carbon dioxide produced by these cells. Blood is conveyed ina closed network composed of 2 circuits in series — the systemic and pulmonary circulation—, each constituted by arteries, capillaries, and veins, under the synchronized action of theleft and right cardiac pumps, respectively. Air is successively inhaled from and exhaled to theatmosphere through the airway openings (nose and/or mouth). In the head, blood generatesthe cerebrospinal fluid in choroid plexi of all compartments of the ventricular system andreceives it in arachnoid villi. Other biofluids are either secreted, such as bile from the liverand breast milk that both transport released substances with specific tasks, or excreted,such as urine from kidneys or sweat from skin glands that both convey useless materials andwaste produced by the cell metabolism. In addition to the convective transport, peristalsis,which results from the radial contraction and relaxation of mural smooth muscles, propelsthe content of the lumen of the muscular bioconduit (e.g., digestive tract) in an anterogradedirection.Blood circulation and air flow in the respiratory tract are widely explored because oftheir vital functions. Note that inhaled air is transported through the respiratory tract bytwo processes: convection down to bronchioles and diffusion down to pulmonary alveoli.1Furthermore, investigations of these physiological flows in deformable bioconduits give riseto models such as the Starling resistance that themselves become object of new study fieldsin physics and mechanics (e.g., collapsible tubes) as well as of new developments in math-ematical modeling and scientific computing. Whereas fluid–structure interaction problemsin aeronautics and civil engineering deal with materials of distinct properties, blood streamand vessel wall correspond to two domains of nearly equal physical properties, as both bloodand vessels have densities close to that of water. New processing strategies must then beconceived

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Pulmonary Airways: 3-D Reconstruction From Multislice CT and Clinical Investigation

Cited by 114 publications

References 21 publications

Airway and pulmonary vascular measurements using contrast-enhanced micro-CT in rodents

Airway and pulmonary vascular measurements using contrast-enhanced micro-CT in rodents

Implementation of Fuzzy Thresholding for Segmentation of Images

Biofluid Flow and Heat Transfer

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