Pulmonary adenofibroma: clinicopathological study of 3 cases of a rare benign lung lesion and review of the literature

Kumar, Rajiv; Desai, Saral; Pai, Trupti; Pramesh, C S; Jambhekar, Nirmala A.

doi:10.1016/j.anndiagpath.2014.04.002

Cited by 17 publications

(41 citation statements)

References 7 publications

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“…The computed tomography showed a well circumscribed nodule in 8 cases (Table 1). A solid cystic lesion was seen in one case [8]. The lesion was located in the left lung in 7 cases and in the right lung in 2 cases in.…”

Section: Discussionmentioning

confidence: 91%

“…This is supported by the fact that the core of the lesion is composed of uncommitted fibroblastic mesenchymal elements which have not attained the capability to differentiate into more specialized, mature elements such as cartilage, smooth muscle or fat. We reviewed nine previous reported cases [1][2][3][4][5][6][7][8] and the present case. The average age at presentation of patients with pulmonary adenofibroma is 49.8 years (29-66 years) with male preponderance (sex ratio=6:4).…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary Adenofibroma: Report of a Rare Case with Amyloid Deposit

Helal¹

2015

J Cytol Histol

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We report a case of a primary lung tumor characterized by complex gland-like spaces lined by simple cuboidal to columnar epithelium surrounded by a hyalinized spindle-cell fibroblastic proliferation reminiscent of adenofibroma of the female genital tract. The lesion occurred in a 56 year-old male with a history of left thoracic pain and hemoptysis. The tumor presented clinically as 1.5 cm solitary lesion and was discovered on chest X-rays. The lesion was treated by lobectomy. The main importance lies in distinguishing this lesion histologically from other types of pulmonary hamartoma, pulmonary blastoma, intrapulmonary solitary fibrous tumor and metastases from soft tissues and visceral sarcomas.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Pulmonary Adenofibroma: Report of a Rare Case with Amyloid Deposit

Helal¹

2015

J Cytol Histol

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“…Pulmonary adenofibroma, a rare benign biphasic tumor involving epithelial and stromal components, with stromal composition of haphazardly arranged bland spindle-cell fibroblastic proliferation and regions of hyalinization, may be distinguished from fibromas by the characteristic appearance of club-shaped and papillary structures (2). CK protein (expressed by the epithelial component) and CD34 (expressed by the stromal component) are also useful for the differential diagnosis between adenofibroma and fibroma, as the former is positive for both markers, while the later is negative (25).…”

Section: A B C D E F Discussionmentioning

confidence: 99%

“…For instance, lung adenofibromas and papillomas have been shown to have a higher recurrence rate than fibroma (2,25,26), and may therefore require further medical treatment in order to prevent recurrence and malignant transformation (2,25,26). By contrast, fibroma is associated with a favorable long-term prognosis (5,(7)(8)(9)(10)(11)(12)(15)(16)(17)(18)(19).…”

Section: A B C D E F Discussionmentioning

confidence: 99%

Endobronchial fibroma in a pneumoconiosis patient with a history of tuberculosis: A case report and literature review

Wang

Liu

et al. 2016

Oncology Letters

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Abstract. Bronchial fibroma is uncommon, with only 18 cases reported since 1948. The current study presents a rare case of endobronchial fibroma, along with a relevant literature review. A 54-year-old male patient with pneumoconiosis and a history of tuberculosis was admitted to the Taihe Hospital Affiliated With Hubei University of Medicine, Shiyan, China, due to refractory dry cough. Computed tomography of the chest showed multiple nodular and confluent opacities in the lung and one cavitation in the right upper lobe region. Bronchoscopy revealed an endobronchial mass in the left main bronchus. A bronchoscopic resection was performed, and the pathological evaluation confirmed fibroma. The patient's dry cough resolved following the removal of the fibroma, and no recurrence was detected during 6 months of follow-up. Endobronchial fibroma is an extremely rare disease, for which a pathological analysis is typically required for an accurate diagnosis. Bronchoscopic treatments, including removal by forceps, argon plasma coagulation and laser or electrocautery snares, may be used to treat patients affected by endobronchial fibroma.

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“…Pulmonary adenofibroma (PAF) is an exceptionally rare benign fibroepithelial lesion that closely recapitulates Müllerian adenofibroma of the genital tract [1] or fibroadenoma of the breast [2]. Since its first description by Scarff and Gowar in 1944 [3] and delineation as distinctive entity by Suster and Moran in 1993 [1], only a few cases of genuine PAFs have been described [4,5].…”

Section: Introductionmentioning

confidence: 99%

Prominent entrapment of respiratory epithelium in primary and metastatic intrapulmonary non-epithelial neoplasms: a frequent morphological pattern closely mimicking adenofibroma and other biphasic pulmonary lesions

et al. 2020

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As one of the most common target organs for hematogenous spread from diverse cancers, biopsy interpretation of lung tumors is complicated by the challenging question of primary versus metastatic and by frequent entrapment of native respiratory glands. Nevertheless, the literature dealing with this issue is surprisingly sparse and no single study has been devoted to this topic. We reviewed 47 surgical lung specimens of non-epithelial neoplasms (38 metastases, mainly from sarcomas and 9 primary lesions) for frequency and pattern of intralesional epithelial entrapment. Respiratory epithelium entrapment was noted in 23/47 (49%) cases (diffuse in 15 and peripheral in 8). Entrapped glands frequently showed prominent regenerative and reactive changes mimicking neoplastic glands. Based on cellularity of the mesenchymal component and the extent, distribution and shape of entrapped respiratory glands, four morphological patterns were recognized: paucicellular sclerosing low-grade neoplasms containing leaflet-like glands indistinguishable from adenofibroma and fibroepithelial hamartomas (n = 11), and biphasic cellular lesions mimicking adenomyoepithelioma (n = 1), biphasic synovial sarcoma (n = 2), and pleuropulmonary blastoma (n = 1). Only a single genuine pulmonary adenofibroma was identified. This study highlights frequent respiratory epithelium entrapment in diverse non-epithelial lung tumors, both primary and metastatic. Recognition of this finding and use of adjunct IHC combined with clinical history should help to avoid misinterpretation as primary pulmonary biphasic neoplasm or as harmless adenofibroma. The vast majority of morphologically defined lung adenofibromas represent adenofibroma-like variants of histogenetically diverse entities so that a diagnosis of adenofibroma should be rendered only very restrictively and then as a diagnosis by exclusion.

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Pulmonary adenofibroma: clinicopathological study of 3 cases of a rare benign lung lesion and review of the literature

Cited by 17 publications

References 7 publications

Pulmonary Adenofibroma: Report of a Rare Case with Amyloid Deposit

Pulmonary Adenofibroma: Report of a Rare Case with Amyloid Deposit

Endobronchial fibroma in a pneumoconiosis patient with a history of tuberculosis: A case report and literature review

Prominent entrapment of respiratory epithelium in primary and metastatic intrapulmonary non-epithelial neoplasms: a frequent morphological pattern closely mimicking adenofibroma and other biphasic pulmonary lesions

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