Pulmonary adenocarcinoma with psammoma bodies is associated with a specific endobronchial ultrasound pattern and a high prevalence of actionable driver mutations

Intrathoracic Lymph Node Microcalcifications are Associated With a High Prevalence of Malignancy and Anaplastic Lymphoma Kinase Rearrangement

“…Moreover, the presence of microcalcifications is typically not suspected before the procedure since, in most cases, they fall below the spatial resolution of CT scans. 27 It is noteworthy that the interobserver agreement for the detection of ILN calcifications was almost perfect. The majority of disagreements occurred when identifying single microcalcifications or local clusters, which is understandable given their subtle nature.…”

“…32 These small calcium collections, which are not detectable in CT scans, can be visualized as microcalcifications during an endobronchial ultrasound examination. 27 A study conducted by Kim et al 12 analyzed pulmonary adenocarcinomas with various genomic alterations and found that 56% of tumors with ALK rearrangement exhibited psammoma bodies upon pathological examination of resected specimens. Furthermore, psammoma bodies were identified as an independent predictor of ALK rearranged adenocarcinoma.…”

“…[23][24][25][26] associated with a high prevalence of malignancy and actionable driver mutations in the setting of lung cancer. 27 The aim of the present study was to assess the prevalence, pattern, and association of ILN calcifications with malignancy, as well as the association of ILN calcifications with specific genomic alterations in patients with lung cancer.…”

Cytomorphological features of ALK‐positive pulmonary adenocarcinoma with abundant psammoma bodies

“…In general, approximately 5% of patients with non-small-cell lung cancer (NSCLC) harbor ALK-positive mutation alteration. 14,15 Pulmonary mucinous adenocarcinoma has a relatively unfavorable prognosis and high rates of recurrence when compared to other subtypes of pulmonary adenocarcinomas. 16 Given the presence of similar features in metastatic PAPBs to the thyroid and primary thyroid tumors with abundant psammoma bodies, it is essential to distinguish these two entities to establish an accurate diagnosis.…”

“…In general, approximately 5% of patients with non‐small‐cell lung cancer (NSCLC) harbor ALK‐positive mutation alteration 14,15 . Pulmonary mucinous adenocarcinoma has a relatively unfavorable prognosis and high rates of recurrence when compared to other subtypes of pulmonary adenocarcinomas 16 .…”